{"id":"https://openalex.org/W1481610475","doi":null,"title":"[Obesity, insulin resistance and skeletal muscle characteristics].","display_name":"[Obesity, insulin resistance and skeletal muscle characteristics].","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1481610475","mag":"1481610475","pmid":"https://pubmed.ncbi.nlm.nih.gov/10513036"},"language":"es","primary_location":{"id":"pmid:10513036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10513036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta cientifica venezolana","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052779965","display_name":"Sonia H. Torres","orcid":"https://orcid.org/0009-0003-6076-5136","observed_orcids":["https://orcid.org/0009-0003-6076-5136"]},"institutions":[{"id":"https://openalex.org/I82002896","display_name":"Universidad Central de Venezuela","ror":"https://ror.org/05kacnm89","country_code":"VE","type":"education","lineage":["https://openalex.org/I82002896"]}],"countries":["VE"],"is_corresponding":true,"raw_author_name":"S H Torres","raw_affiliation_strings":["Secci\u00f3n para el Estudio de la Adaptaci\u00f3n Muscular, Instituto de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Sabana Grande, Caracas. heckers@camelot.rect.ucv.ve","Universidad Central de Venezuela, Facultad de Medicina, Caracas, Distrito Federal, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Secci\u00f3n para el Estudio de la Adaptaci\u00f3n Muscular, Instituto de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Sabana Grande, Caracas. heckers@camelot.rect.ucv.ve","institution_ids":["https://openalex.org/I82002896"]},{"raw_affiliation_string":"Universidad Central de Venezuela, Facultad de Medicina, Caracas, Distrito Federal, Venezuela","institution_ids":["https://openalex.org/I82002896"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052779965"],"corresponding_institution_ids":["https://openalex.org/I82002896"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"1","first_page":"34","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.23569999635219574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9919999837875366},{"id":"https://openalex.org/keywords/type-iib-fibers","display_name":"type IIb muscle fibers","score":0.7929999828338623},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.8519999980926514},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.4659999907016754},{"id":"https://openalex.org/keywords/glut4","display_name":"GLUT4","score":0.6290000081062317},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.7300000190734863},{"id":"https://openalex.org/keywords/muscle-blood-flow","display_name":"muscle blood flow","score":0.6769999861717224},{"id":"https://openalex.org/keywords/sympathetic-nerve-activity","display_name":"sympathetic activity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/capillary-density","display_name":"capillary density","score":0.6019999980926514},{"id":"https://openalex.org/keywords/membrane-phospholipids","display_name":"membrane phospholipids","score":0.6349999904632568},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/glycogen-synthase","display_name":"glycogen synthase","score":0.8379999995231628},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.675000011920929},{"id":"https://openalex.org/keywords/body-fat-distribution","display_name":"body fat distribution","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8734883666038513},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8474428057670593},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8152509927749634},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6941087245941162},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.666512668132782},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5560054779052734},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.5391047596931458},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.4933997690677643},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.460287481546402},{"id":"https://openalex.org/C2777499176","wikidata":"https://www.wikidata.org/wiki/Q174936","display_name":"Glycogen","level":2,"score":0.4369300901889801},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.43000173568725586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.352301687002182},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3499405086040497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34844160079956055}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:10513036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10513036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta cientifica venezolana","raw_type":"English Abstract"},{"id":"mag:1481610475","doi":null,"is_oa":false,"landing_page_url":"https://biblat.unam.mx/es/revista/acta-cientifica-venezolana/articulo/obesidad-resistencia-a-la-insulina-y-caracteristicas-del-musculo-esqueletico","pdf_url":null,"source":{"id":"https://openalex.org/S4306500303","display_name":"Acta cient\u00edfica venezolana","issn_l":"0001-5504","issn":["0001-5504"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta cient\u00edfica venezolana","raw_type":null},{"id":"mag:2404030574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10513036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W63399495","https://openalex.org/W136436570","https://openalex.org/W1863103714","https://openalex.org/W1940582649","https://openalex.org/W1973402633","https://openalex.org/W1976937132","https://openalex.org/W1982688466","https://openalex.org/W1989502392","https://openalex.org/W2003867411","https://openalex.org/W2004235078","https://openalex.org/W2012898950","https://openalex.org/W2024907664","https://openalex.org/W2025997353","https://openalex.org/W2038952019","https://openalex.org/W2049988592","https://openalex.org/W2061282633","https://openalex.org/W2076168144","https://openalex.org/W2079285443","https://openalex.org/W2085194341","https://openalex.org/W2092942907","https://openalex.org/W2094029588","https://openalex.org/W2096579262","https://openalex.org/W2096773810","https://openalex.org/W2115034442","https://openalex.org/W2116824077","https://openalex.org/W2118428120","https://openalex.org/W2122248435","https://openalex.org/W2134604231","https://openalex.org/W2155605721","https://openalex.org/W2158088707","https://openalex.org/W2163098588","https://openalex.org/W2164471793","https://openalex.org/W2168808578","https://openalex.org/W2170379386","https://openalex.org/W2171109639","https://openalex.org/W2206444408","https://openalex.org/W2279534165","https://openalex.org/W2281118755","https://openalex.org/W2295252364","https://openalex.org/W2315929780","https://openalex.org/W2341717561","https://openalex.org/W2414291743","https://openalex.org/W2419197809","https://openalex.org/W3000571484"],"related_works":["https://openalex.org/W1988719613","https://openalex.org/W2073151991","https://openalex.org/W2047116124","https://openalex.org/W2561422649","https://openalex.org/W2083708851","https://openalex.org/W1582716167","https://openalex.org/W2095780917","https://openalex.org/W1592900851","https://openalex.org/W2164471793","https://openalex.org/W1940582649"],"abstract_inverted_index":{"Insulin":[0],"resistance":[1,214],"seems":[2],"to":[3,17,40,110,134,152,155,162,217],"be":[4],"a":[5,18,54,156],"metabolic":[6,94,191],"aberration":[7],"associated":[8],"with":[9,92],"obesity.":[10],"Impaired":[11],"insulin":[12,45,73,113,121,168,213],"action":[13,122],"is":[14,38,44,85],"also":[15],"central":[16],"cluster":[19],"of":[20,71,87,90,167,176,193,206],"diseases":[21],"including":[22],"non-insulin":[23],"dependent":[24,46],"diabetes,":[25],"hypertension,":[26],"dyslipidemias":[27],"and":[28,50,95,104,112,123,211],"atherosclerosis.":[29],"Body":[30],"fat":[31],"distribution,":[32],"especially":[33],"upper":[34],"body":[35,65],"segment":[36],"obesity":[37,111,210],"related":[39,109],"insulin-resistance.":[41],"Glucose":[42],"uptake":[43,126],"in":[47,79,127,158,171,182,190,195,199,209,212,222],"skeletal":[48,57,83,128],"muscle":[49,58,84,129,153,164,196],"adipose":[51],"tissue.":[52,81],"From":[53],"quantitative":[55],"standpoint,":[56],"has":[59,75,107],"the":[60,69,172,203],"greater":[61],"impact":[62],"on":[63],"whole":[64],"glucose":[66,125,183,194,220],"economy,":[67],"therefore":[68],"cause":[70],"altered":[72],"sensitivity":[74],"been":[76,108],"looked":[77],"for":[78],"this":[80],"The":[82,115],"composed":[86],"different":[88,116],"types":[89],"fibers":[91,100],"specific":[93],"circulatory":[96],"characteristics;":[97],"type":[98],"IIB":[99],"are":[101],"less":[102],"insulin-sensitive":[103],"their":[105],"proportion":[106],"resistance.":[114],"factors":[117],"that":[118],"may":[119],"impair":[120],"alter":[124],"are:":[130],"lower":[131],"blood":[132],"flow":[133],"muscle,":[135],"produced":[136],"by":[137,142],"either":[138],"decreased":[139],"vasodilation":[140],"or":[141,161],"increased":[143],"sympathetic":[144],"nerve":[145],"activity;":[146],"augmented":[147],"diffusion":[148],"distance":[149],"from":[150],"capillaries":[151],"due":[154],"decrease":[157,166,181],"capillary":[159],"number":[160],"enlarged":[163],"cells;":[165],"receptors;":[169],"change":[170],"fatty":[173],"acid":[174],"profile":[175],"major":[177],"membrane":[178],"structural":[179],"phospholipids;":[180],"transporters":[184],"(GLUT":[185],"4)":[186],"and/or":[187],"hexokinase;":[188],"impairment":[189],"routes":[192],"as":[197],"reduction":[198],"glycogen":[200],"synthase.":[201],"Also,":[202],"high":[204],"rate":[205],"lipolysis":[207],"present":[208],"could":[215],"lead":[216],"an":[218],"impaired":[219],"oxidation":[221],"muscle.":[223]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}