{"id":"https://openalex.org/W1481543280","doi":"https://doi.org/10.1016/s0021-9258(18)53114-8","title":"Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence.","display_name":"Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence.","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W1481543280","doi":"https://doi.org/10.1016/s0021-9258(18)53114-8","mag":"1481543280","pmid":"https://pubmed.ncbi.nlm.nih.gov/8463210"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)53114-8","doi":"https://doi.org/10.1016/s0021-9258(18)53114-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)53114-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)53114-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113461919","display_name":"Majed M. Hamawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.M. Hamawy","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111864498","display_name":"Stephen E. Mergenhagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.E. Mergenhagen","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108352806","display_name":"Reuben P. Siraganian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.P. Siraganian","raw_affiliation_strings":["Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.2782,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.97218499,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"268","issue":"10","first_page":"6851","last_page":"6854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pp125fak","display_name":"pp125FAK","score":0.9760000109672546},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fcepsilonri","display_name":"Fc\u03b5RI","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9589999914169312},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8510000109672546},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.9810000061988831},{"id":"https://openalex.org/keywords/calcium-ionophore","display_name":"calcium ionophore","score":0.7429999709129333},{"id":"https://openalex.org/keywords/receptor-signaling","display_name":"receptor signaling","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6559733152389526},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6052903532981873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5547670125961304},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5431238412857056},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4986426830291748},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.441837877035141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42604848742485046},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4235122799873352},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34652405977249146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2569998502731323},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19334080815315247}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011940","descriptor_name":"Receptor Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017455","descriptor_name":"Receptors, IgE","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051416","descriptor_name":"Focal Adhesion Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)53114-8","doi":"https://doi.org/10.1016/s0021-9258(18)53114-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)53114-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8463210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8463210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)53114-8","doi":"https://doi.org/10.1016/s0021-9258(18)53114-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)53114-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W118896869","https://openalex.org/W1482211797","https://openalex.org/W1500732610","https://openalex.org/W1506801516","https://openalex.org/W1508470956","https://openalex.org/W1519223405","https://openalex.org/W1542743692","https://openalex.org/W1543778012","https://openalex.org/W1549544590","https://openalex.org/W1557763992","https://openalex.org/W1588749554","https://openalex.org/W1592229285","https://openalex.org/W1704017123","https://openalex.org/W1750204594","https://openalex.org/W1960680499","https://openalex.org/W1966475130","https://openalex.org/W1968585354","https://openalex.org/W1982072152","https://openalex.org/W1986549185","https://openalex.org/W2003794283","https://openalex.org/W2006892275","https://openalex.org/W2011279348","https://openalex.org/W2012385196","https://openalex.org/W2020455973","https://openalex.org/W2025018535","https://openalex.org/W2043117244","https://openalex.org/W2048345403","https://openalex.org/W2051942264","https://openalex.org/W2053023240","https://openalex.org/W2058170261","https://openalex.org/W2059188737","https://openalex.org/W2068410918","https://openalex.org/W2069834296","https://openalex.org/W2070431736","https://openalex.org/W2070846527","https://openalex.org/W2096049968","https://openalex.org/W2106217238","https://openalex.org/W2108674983","https://openalex.org/W2116562044","https://openalex.org/W2119828692","https://openalex.org/W2134606648","https://openalex.org/W2139494439","https://openalex.org/W2140152586","https://openalex.org/W2148849095","https://openalex.org/W2152329591","https://openalex.org/W2156411608","https://openalex.org/W2399838398","https://openalex.org/W2409196608"],"related_works":["https://openalex.org/W1557763992","https://openalex.org/W1581792908","https://openalex.org/W2003329920","https://openalex.org/W2169429927","https://openalex.org/W2060922997","https://openalex.org/W1604722617","https://openalex.org/W1519260014","https://openalex.org/W2135804146","https://openalex.org/W1968585354","https://openalex.org/W1978568961"],"abstract_inverted_index":{"The":[0,110,162],"aggregation":[1,87,102],"of":[2,22,35,51,74,83,108,113,121,132,144,152,159,176],"the":[3,19,49,119,150,157],"high":[4],"affinity":[5],"IgE":[6],"receptor":[7],"(Fc":[8],"epsilon":[9,53,65,85,100,140,172],"RI)":[10],"in":[11,60,67,96,135],"adherent":[12,61,68,136],"rat":[13],"basophilic":[14],"leukemia":[15],"(RBL-2H3)":[16],"cells":[17,69,98],"induces":[18],"tyrosine":[20,30,72,106,130,142,174],"phosphorylation":[21,73,107,131,143,175],"several":[23],"proteins.":[24,37],"We":[25],"examined":[26],"whether":[27],"focal":[28],"adhesion-associated":[29],"kinase,":[31],"pp125FAK,":[32],"is":[33,168],"one":[34],"these":[36],"Anti-pp125FAK":[38],"monoclonal":[39],"antibody":[40],"immunoblotted":[41],"and":[42,88],"precipitated":[43],"a":[44],"115-kDa":[45],"tyrosine-phosphorylated":[46,58],"protein.":[47],"In":[48,94],"absence":[50],"Fc":[52,64,84,99,139,171],"RI":[54,66,86,101],"aggregation,":[55],"pp125FAK":[56,133,145],"was":[57,78,89],"only":[59,134],"cells.":[62,137],"Aggregating":[63],"markedly":[70],"enhanced":[71,111],"pp125FAK.":[75,109,177],"This":[76],"increase":[77],"detectable":[79],"within":[80],"1":[81],"min":[82],"maximal":[90],"by":[91,115,125,149],"15":[92],"min.":[93],"contrast,":[95],"nonadherent":[97],"did":[103],"not":[104],"induce":[105],"influx":[112],"calcium":[114,116,160],"ionophore":[117],"or":[118],"activation":[120,151],"protein":[122,153],"kinase":[123,154],"C":[124,155],"phorbol":[126],"myristate":[127],"acetate":[128],"induced":[129],"Thus,":[138],"RI-induced":[141,173],"could":[146],"be":[147],"mediated":[148],"and/or":[156],"induction":[158],"influx.":[161],"data":[163],"indicate":[164],"that":[165],"cell":[166],"adherence":[167],"essential":[169],"for":[170]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
