{"id":"https://openalex.org/W1481388024","doi":"https://doi.org/10.1016/s0021-9258(19)43251-1","title":"Origin of the High Molecular Weight Activator of Prekallikrein","display_name":"Origin of the High Molecular Weight Activator of Prekallikrein","publication_year":1973,"publication_date":"1973-11-01","ids":{"openalex":"https://openalex.org/W1481388024","doi":"https://doi.org/10.1016/s0021-9258(19)43251-1","mag":"1481388024","pmid":"https://pubmed.ncbi.nlm.nih.gov/4127217"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)43251-1","doi":"https://doi.org/10.1016/s0021-9258(19)43251-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)43251-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)43251-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041058515","display_name":"Andranik Bagdasarian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andranik Bagdasarian","raw_affiliation_strings":["From the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079935004","display_name":"Biswajit Lahiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biswajit Lahiri","raw_affiliation_strings":["From the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["From the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.9738,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.95040761,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"248","issue":"22","first_page":"7742","last_page":"7747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-xii","display_name":"factor XII","score":0.8820000290870667},{"id":"https://openalex.org/keywords/prekallikrein","display_name":"prekallikrein","score":0.9039999842643738},{"id":"https://openalex.org/keywords/plasmin","display_name":"plasmin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/kallikrein","display_name":"kallikrein","score":0.9660000205039978},{"id":"https://openalex.org/keywords/proteolytic-digestion","display_name":"proteolytic digestion","score":0.6489999890327454},{"id":"https://openalex.org/keywords/positive-feedback-control","display_name":"positive feedback control","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C152328610","wikidata":"https://www.wikidata.org/wiki/Q7240014","display_name":"Prekallikrein","level":4,"score":0.8836672306060791},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5555934906005859},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45226234197616577},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.37668782472610474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3258284330368042},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10332706570625305},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08495709300041199}],"mesh":[{"descriptor_ui":"D000510","descriptor_name":"Alpha-Globulins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001778","descriptor_name":"Blood Coagulation Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004589","descriptor_name":"Electrophoresis, Disc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005779","descriptor_name":"Immunodiffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)43251-1","doi":"https://doi.org/10.1016/s0021-9258(19)43251-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)43251-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:4127217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4127217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)43251-1","doi":"https://doi.org/10.1016/s0021-9258(19)43251-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)43251-1","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1510168465","https://openalex.org/W1572081553","https://openalex.org/W1588733323","https://openalex.org/W1777003282","https://openalex.org/W1931728118","https://openalex.org/W2019244584","https://openalex.org/W2117343102","https://openalex.org/W2136573989","https://openalex.org/W2151463374","https://openalex.org/W2208527426","https://openalex.org/W2333330110","https://openalex.org/W2397824302","https://openalex.org/W4251186225","https://openalex.org/W4313316390"],"related_works":["https://openalex.org/W1572081553","https://openalex.org/W2019096848","https://openalex.org/W2034666340","https://openalex.org/W2062544979","https://openalex.org/W2946255631","https://openalex.org/W2093213625","https://openalex.org/W2119146651","https://openalex.org/W1976603670","https://openalex.org/W2415989515","https://openalex.org/W623533348"],"abstract_inverted_index":{"Abstract":[0],"Two":[1],"lines":[2],"of":[3,12,86,104,113,122,130,144,167,204,208],"evidence":[4],"suggest":[5,213],"that":[6,94,157,214],"the":[7,62,66,84,95,102,120,123,131,147,197,205,231,236],"high":[8,186],"molecular":[9,179,250],"weight":[10,180,251],"activator":[11,40,88,97,125,149,174],"prekallikrein":[13,209,232,252],"(large":[14],"activator)":[15],"(Bagdasarian,":[16],"A.,":[17],"Talamo,":[18],"R.":[19,23],"C.,":[20],"and":[21,52,61,73,227],"Colman,":[22],"W.":[24],"(1973)":[25],"J.":[26],"Biol.":[27],"Chem.":[28],"248,":[29],"3456\u20133463)":[30],"is":[31,159],"derived":[32],"from":[33,45,137],"coagulation":[34],"factor":[35,50,59,67,105,116,145,168,215,246],"XII":[36,60,68,106,117,169,216,247],"(Hageman":[37],"factor).":[38],"Large":[39],"could":[41],"not":[42,151],"be":[43,99],"isolated":[44,136],"plasma":[46,109,138,221],"congenitally":[47],"deficient":[48],"in":[49,75,119,230],"XII,":[51,146],"partial":[53],"immunologic":[54],"identity":[55],"was":[56,70,89,150],"demonstrated":[57],"between":[58],"large":[63,87,96,124,148,173,198],"activator.":[64,192],"When":[65],"molecule":[69,83],"denatured,":[71],"reduced,":[72],"run":[74],"disc":[76],"gels":[77],"containing":[78],"sodium":[79],"dodecyl":[80],"sulfate,":[81],"no":[82],"size":[85],"obtained.":[90],"This":[91],"observation":[92],"suggested":[93],"might":[98,239],"formed":[100,196,238],"by":[101,107,141,154,244],"digestion":[103,143,166],"a":[108],"proteolytic":[110,222],"enzyme.":[111],"Incubation":[112],"plasmin":[114,142],"with":[115,224],"resulted":[118],"formation":[121],"which":[126,200],"accounted":[127],"for":[128],"22%":[129],"total":[132,206],"activators":[133,207,233],"formed.":[134,234],"Whether":[135],"or":[139],"generated":[140],"further":[152],"attacked":[153],"plasmin,":[155],"indicating":[156],"it":[158],"an":[160],"end":[161],"product.":[162],"In":[163],"contrast,":[164],"kallikrein":[165,237],"failed":[170,188],"to":[171,189,220,248],"produce":[172],"but":[175],"did":[176],"yield":[177],"low":[178,249],"activators.":[181,253],"Thrombin,":[182],"even":[183],"at":[184],"very":[185],"concentrations,":[187],"generate":[190],"any":[191],"Pancreatic":[193],"trypsin":[194],"also":[195],"activator,":[199],"comprised":[201],"only":[202],"10%":[203],"produced.":[210],"The":[211],"results":[212],"exhibits":[217],"differential":[218],"susceptibility":[219],"enzymes":[223],"both":[225],"quantitative":[226],"qualitative":[228],"changes":[229],"Moreover,":[235],"exert":[240],"positive":[241],"feedback":[242],"control":[243],"converting":[245]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}