{"id":"https://openalex.org/W148138771","doi":null,"title":"First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.","display_name":"First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W148138771","mag":"148138771","pmid":"https://pubmed.ncbi.nlm.nih.gov/8780157"},"language":"en","primary_location":{"id":"pmid:8780157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019564690","display_name":"H. Naiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Naiki","raw_affiliation_strings":["Department of Pathology, Fukui Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Fukui Medical School, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"last","author":{"id":null,"display_name":"K Nakakuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Nakakuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7528,"has_fulltext":false,"cited_by_count":244,"citation_normalized_percentile":{"value":0.94456566,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"74","issue":"2","first_page":"374","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8820000290870667},{"id":"https://openalex.org/keywords/amyloid-beta-40","display_name":"A\u03b240","score":0.9169999957084656},{"id":"https://openalex.org/keywords/first-order-kinetic-model","display_name":"first-order kinetic model","score":0.7639999985694885},{"id":"https://openalex.org/keywords/polymerization-kinetics","display_name":"polymerization kinetics","score":0.8029999732971191},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.7519999742507935},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.9940000176429749},{"id":"https://openalex.org/keywords/depolymerization","display_name":"depolymerization","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.8513379096984863},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6932864189147949},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6336901187896729},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5671367645263672},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.4850751459598541},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4605731964111328},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.431112140417099},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2725202143192291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1405855417251587},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10591664910316467},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.09267017245292664},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8780157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"mag:148138771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8780157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060883541","https://openalex.org/W2400583158","https://openalex.org/W1582745215","https://openalex.org/W2343179054","https://openalex.org/W2345351264","https://openalex.org/W96912361","https://openalex.org/W2080543662","https://openalex.org/W2012901990","https://openalex.org/W2145904082","https://openalex.org/W2052149626"],"abstract_inverted_index":{"Recently,":[0],"several":[1],"studies":[2],"have":[3,37],"proposed":[4],"models":[5,18],"describing":[6],"the":[7,28,35,54,76,88,110,137,165,171,184,198,202,206,209,213,223,231,235,241,244,266,273,279],"mechanisms":[8],"of":[9,34,60,70,81,99,113,139,153,167,173,201,208,215,225,238,243,246,268,276,281],"Alzheimer's":[10],"beta-amyloid":[11,45,62,71,114,120,140,226,254,269],"fibril":[12,115,255],"formation":[13,116,133,256],"in":[14,117,127],"vitro.":[15,118],"However,":[16],"these":[17,61],"are":[19],"somewhat":[20],"controversial":[21],"and":[22,52,78,83,96,180,189,205,230,248],"no":[23],"exact":[24],"kinetic":[25,263],"analyses":[26],"measuring":[27],"polymerization":[29,216,247],"velocity":[30],"as":[31,162],"an":[32],"indicator":[33],"reaction,":[36],"thus":[38],"far":[39],"been":[40],"available.":[41],"We":[42,104],"first":[43],"formed":[44],"fibrils":[46,63,72,121,141,155,227,270],"from":[47],"a":[48,158,261],"synthetic":[49],"peptide,":[50],"beta-amyloid(1-40),":[51],"determined":[53],"optimum":[55],"conditions":[56,128],"for":[57],"quantitative":[58],"fluorometry":[59,148],"with":[64,87,124,144],"thioflavine":[65,94,168],"T.":[66],"Optimum":[67],"fluorescence":[68,166],"measurements":[69],"were":[73,122],"obtained":[74],"at":[75],"excitation":[77],"emission":[79],"wavelengths":[80],"446":[82],"490":[84],"nm,":[85],"respectively,":[86],"reaction":[89],"mixture":[90],"containing":[91],"5":[92],"microM":[93],"T":[95],"50":[97],"mM":[98],"glycine-NaOH":[100],"buffer,":[101],"pH":[102,178],"8.5.":[103],"then":[105],"focused":[106],"our":[107],"study":[108],"on":[109,183],"extension":[111,138,152,174,239,267],"phase":[112],"When":[119],"incubated":[123],"monomeric":[125],"beta-amyloid(1-40)":[126,232,277],"where":[129],"de":[130],"novo":[131],"seed":[132],"does":[134],"not":[135],"occur,":[136],"was":[142,175,181,195,217,240],"observed":[143,196],"electron":[145],"microscopy.":[146],"Quantitative":[147],"revealed":[149],"that:":[150],"(a)":[151],"amyloid":[154],"proceeded":[156],"by":[157,164,260],"pseudo-first-order":[159],"exponential":[160],"increase":[161],"measured":[163],"T;":[169],"(b)":[170],"rate":[172,204,214,237],"maximum":[176],"around":[177],"7.5,":[179],"dependent":[182],"incubation":[185],"temperature.":[186],"Between":[187],"20":[188],"37":[190],"degrees":[191],"C,":[192],"good":[193],"linearity":[194],"between":[197],"common":[199],"logarithm":[200],"initial":[203],"reciprocal":[207],"absolute":[210],"temperature;":[211],"(c)":[212],"found":[218],"to":[219,222],"be":[220,258],"proportional":[221],"product":[224],"number":[228],"concentration":[229],"concentration;":[233],"(d)":[234],"net":[236],"sum":[242],"rates":[245],"depolymerization.":[249],"These":[250],"results":[251],"show":[252],"that":[253],"can":[257],"explained":[259],"first-order":[262],"model:":[264],"i.e.,":[265],"proceeds":[271],"via":[272],"consecutive":[274],"association":[275],"onto":[278],"ends":[280],"existing":[282],"fibrils.":[283]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
