{"id":"https://openalex.org/W1480503570","doi":null,"title":"25-hydroxyvitamin D Concentrations in Patients with Optic Neuritis as a Clinically Isolated Syndrome and Healthy Controls.","display_name":"25-hydroxyvitamin D Concentrations in Patients with Optic Neuritis as a Clinically Isolated Syndrome and Healthy Controls.","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W1480503570","mag":"1480503570","pmid":"https://pubmed.ncbi.nlm.nih.gov/22708027","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3372073"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3372073","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3372073/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3372073/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Prev Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3372073/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001360175","display_name":"Masoud Etemadifar","orcid":"https://orcid.org/0000-0002-0066-3782","observed_orcids":["https://orcid.org/0000-0002-0066-3782","https://orcid.org/0000-0003-3318-7513"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Masoud Etemadifar","raw_affiliation_strings":["Isfahan Eye Research Center (IERC), Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isfahan Eye Research Center (IERC), Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051228653","display_name":"Seyed-Hossein Abtahi","orcid":"https://orcid.org/0000-0002-1459-6752","observed_orcids":["https://orcid.org/0000-0002-1459-6752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seyed-Hossein Abtahi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067758084","display_name":"Hassan Razmjoo","orcid":"https://orcid.org/0000-0001-7032-1043","observed_orcids":["https://orcid.org/0000-0001-7032-1043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hassan Razmjoo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103192933","display_name":"Mohammad-Ali Abtahi","orcid":"https://orcid.org/0000-0003-4154-8446","observed_orcids":["https://orcid.org/0000-0003-4154-8446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad-Ali Abtahi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028612020","display_name":"Alireza Dehghani","orcid":"https://orcid.org/0000-0002-6313-0262","observed_orcids":["https://orcid.org/0000-0002-6313-0262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alireza Dehghani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103197736","display_name":"Mehri Salari","orcid":"https://orcid.org/0000-0002-1675-681X","observed_orcids":["https://orcid.org/0000-0002-1675-681X","https://orcid.org/0000-0001-7102-821X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehri Salari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084434940","display_name":"Amir\u2010Hadi Maghzi","orcid":"https://orcid.org/0000-0002-4306-347X","observed_orcids":["https://orcid.org/0000-0002-4306-347X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amir-Hadi Maghzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076093756","display_name":"Mojtaba Akbari","orcid":"https://orcid.org/0000-0002-5777-9612","observed_orcids":["https://orcid.org/0000-0002-5777-9612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mojtaba Akbari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0595,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.85689126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"5","first_page":"313","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.44190001487731934,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9929999709129333},{"id":"https://openalex.org/keywords/clinically-isolated-syndrome","display_name":"clinically isolated syndrome","score":0.9639999866485596},{"id":"https://openalex.org/keywords/optic-neuritis","display_name":"optic neuritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/serum-vitamin-d-levels","display_name":"serum vitamin D levels","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9540410041809082},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.8752046823501587},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.8115469813346863},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.7331942319869995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6087360382080078},{"id":"https://openalex.org/C2776572573","wikidata":"https://www.wikidata.org/wiki/Q972514","display_name":"Optic neuritis","level":3,"score":0.6060868501663208},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5844425559043884},{"id":"https://openalex.org/C2781028063","wikidata":"https://www.wikidata.org/wiki/Q338802","display_name":"Clinically isolated syndrome","level":3,"score":0.5485488176345825},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.3967607021331787},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12634068727493286}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3372073","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3372073/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3372073/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Prev Med","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2381687","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3372073","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22708027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22708027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of preventive medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8e8a3b449e494a3eb09a6330556f444a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8e8a3b449e494a3eb09a6330556f444a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Preventive Medicine, Vol 3, Iss 5, Pp 313-317 (2012)","raw_type":"article"},{"id":"mag:1480503570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22708027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3372073","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3372073/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3372073/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Prev Med","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1480503570.pdf","grobid_xml":"https://content.openalex.org/works/W1480503570.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1606806706","https://openalex.org/W1967938396","https://openalex.org/W1978321769","https://openalex.org/W1988024483","https://openalex.org/W2008330041","https://openalex.org/W2021610751","https://openalex.org/W2082422372","https://openalex.org/W2105490558","https://openalex.org/W2109978145","https://openalex.org/W2111516307","https://openalex.org/W2112948089","https://openalex.org/W2125442932","https://openalex.org/W2126574528","https://openalex.org/W2149134458","https://openalex.org/W2156478599","https://openalex.org/W2163507707","https://openalex.org/W2171753008","https://openalex.org/W2288234740"],"related_works":["https://openalex.org/W1777078286","https://openalex.org/W2143542762","https://openalex.org/W4223551073","https://openalex.org/W2510526558","https://openalex.org/W2042422969","https://openalex.org/W2772576356","https://openalex.org/W2792221638","https://openalex.org/W2093519887","https://openalex.org/W2336008515","https://openalex.org/W2553291339"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1],"onset":[2],"of":[3,9,25,88,142,168,204],"multiple":[4],"sclerosis":[5],"in":[6,29,119,156,214],"the":[7,10,120,140,166,192],"majority":[8],"cases":[11],"occurs":[12],"as":[13,50,84,96],"a":[14,51,147],"clinically":[15],"isolated":[16,53],"syndrome":[17],"(CIS).":[18],"We":[19,115],"sought":[20],"to":[21,158],"assess":[22],"serum":[23,85,205],"levels":[24,87,141],"25-hydroxyvitamin":[26],"D":[27,80,154,186,219],"(25-OHD)":[28],"CIS":[30,48,126,145,208,225],"patients":[31,41,127,146,209],"and":[32,44,56,59,65,74,93,109,128,179,210],"healthy":[33,61,159,211],"controls.":[34,212],"METHODS:":[35],"In":[36],"this":[37],"cross-sectional":[38],"study":[39],"40":[40,57],"(36":[42],"women":[43,64],"4":[45],"men)":[46,67],"with":[47],"manifesting":[49],"single":[52],"optic":[54],"neuritis":[55],"Age-":[58],"sex-matched":[60],"controls":[62,129,160],"(35":[63],"5":[66],"were":[68,188],"enrolled":[69],"between":[70,125,191,207],"late":[71],"October":[72],"2010":[73],"early":[75],"March":[76],"2011.":[77],"General":[78],"vitamin":[79,153,185,218],"deficiency":[81,155,187,220],"was":[82,94,221],"defined":[83],"25-OHD":[86,100,106,206],"lower":[89],"than":[90],"20":[91],"ng/ml":[92],"classified":[95],"mild":[97,174],"(15":[98],"<":[99,105],"<20":[101],"ng/ml),":[102,108],"moderate":[103,180],"(8":[104],"<15":[107],"severe":[110,152,217],"(25-OHD":[111],"<8":[112],"ng/ml).":[113],"RESULTS:":[114],"found":[116],"no":[117],"difference":[118,203],"median":[121],"interquartile":[122],"range":[123],"[IQR]":[124],"(17.95":[130],"[10.40-29.13]":[131],"vs.":[132,162,171,176,182],"17.00":[133],"[12.25-31.00];":[134],"P=0.57).":[135],"However,":[136,213],"when":[137],"stratified":[138],"by":[139],"deficiency,":[143],"among":[144,224],"significantly":[148],"higher":[149],"proportion":[150],"had":[151],"comparison":[157],"(20%":[161],"2.5%;":[163],"P=0.034).":[164],"Nevertheless,":[165],"frequency":[167],"general":[169],"(62.5%":[170],"60%,":[172],"P=0.82),":[173],"(25%":[175],"30%,":[177],"P=0.80),":[178],"(17.5%":[181],"27.5%,":[183],"P=0.42)":[184],"not":[189,199],"different":[190],"two":[193],"groups.":[194],"CONCLUSIONS:":[195],"Our":[196],"findings":[197],"do":[198],"indicate":[200],"any":[201],"significant":[202],"our":[215],"series":[216],"more":[222],"frequent":[223],"patients.":[226]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}