{"id":"https://openalex.org/W1480166232","doi":"https://doi.org/10.1182/blood.v86.8.2922.2922","title":"The C5R protocol: a regimen of high-dose chemotherapy and radiotherapy in primary cerebral non-Hodgkin's lymphoma of patients with no known cause of immunosuppression [see comments]","display_name":"The C5R protocol: a regimen of high-dose chemotherapy and radiotherapy in primary cerebral non-Hodgkin's lymphoma of patients with no known cause of immunosuppression [see comments]","publication_year":1995,"publication_date":"1995-10-15","ids":{"openalex":"https://openalex.org/W1480166232","doi":"https://doi.org/10.1182/blood.v86.8.2922.2922","mag":"1480166232","pmid":"https://pubmed.ncbi.nlm.nih.gov/7579384"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v86.8.2922.2922","doi":"https://doi.org/10.1182/blood.v86.8.2922.2922","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v86.8.2922.2922","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042202815","display_name":"Jean\u2010Yves Blay","orcid":"https://orcid.org/0000-0001-7190-120X","observed_orcids":["https://orcid.org/0000-0001-7190-120X"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"JY Blay","raw_affiliation_strings":["Department of Medicine, Centre Leon Berard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Centre Leon Berard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110126419","display_name":"Damien Bouhour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D Bouhour","raw_affiliation_strings":["Department of Medicine, Centre Leon Berard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Centre Leon Berard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020593337","display_name":"C. Carri\u00e9","orcid":"https://orcid.org/0000-0002-0766-2547","observed_orcids":["https://orcid.org/0000-0002-0766-2547"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Carrie","raw_affiliation_strings":["Department of Medicine, Centre Leon Berard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Centre Leon Berard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068257880","display_name":"\u00c9ric Bouffet","orcid":"https://orcid.org/0000-0002-6832-6539","observed_orcids":["https://orcid.org/0000-0002-6832-6539"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E Bouffet","raw_affiliation_strings":["Department of Medicine, Centre Leon Berard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Centre Leon Berard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109155060","display_name":"Maud Brunat-Mentigny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Brunat-Mentigny","raw_affiliation_strings":["Department of Medicine, Centre Leon Berard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Centre Leon Berard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105348558","display_name":"Thierry O. Philip","orcid":"https://orcid.org/0009-0007-7979-6847","observed_orcids":["https://orcid.org/0009-0007-7979-6847"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"T Philip","raw_affiliation_strings":["Department of Medicine, Centre Leon Berard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Centre Leon Berard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112235249","display_name":"Pierre Biron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Biron","raw_affiliation_strings":["Department of Medicine, Centre Leon Berard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Centre Leon Berard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210105738"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.6733,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.89068269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"86","issue":"8","first_page":"2922","last_page":"2929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cranial-irradiation","display_name":"cranial irradiation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.5189999938011169},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9760000109672546},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9179999828338623},{"id":"https://openalex.org/keywords/international-prognostic-index","display_name":"International Prognostic Index","score":0.890999972820282},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8920000195503235},{"id":"https://openalex.org/keywords/immunocompetent-patient","display_name":"immunocompetent patient","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8743158578872681},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6856802701950073},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6482458710670471},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5764809846878052},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.557159960269928},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.5460174679756165},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.5327368378639221},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5158816576004028},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49274805188179016},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.44709014892578125},{"id":"https://openalex.org/C2778476033","wikidata":"https://www.wikidata.org/wiki/Q1667625","display_name":"International Prognostic Index","level":4,"score":0.4164179265499115},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38362395763397217},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.2687230110168457}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016371","descriptor_name":"Cranial Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017713","descriptor_name":"Platelet Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v86.8.2922.2922","doi":"https://doi.org/10.1182/blood.v86.8.2922.2922","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v86.8.2922.2922","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v86.8.2922.bloodjournal8682922","doi":"https://doi.org/10.1182/blood.v86.8.2922.bloodjournal8682922","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v86.8.2922.bloodjournal8682922","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:7579384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7579384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1243984806","https://openalex.org/W1500244602","https://openalex.org/W1814753114","https://openalex.org/W1860711823","https://openalex.org/W1898273653","https://openalex.org/W1959628099","https://openalex.org/W1979300931","https://openalex.org/W1982135969","https://openalex.org/W1982149777","https://openalex.org/W1988295204","https://openalex.org/W1991876384","https://openalex.org/W1994718483","https://openalex.org/W2013547081","https://openalex.org/W2013683913","https://openalex.org/W2024012030","https://openalex.org/W2026487729","https://openalex.org/W2031750852","https://openalex.org/W2033694616","https://openalex.org/W2042171450","https://openalex.org/W2062968968","https://openalex.org/W2079621758","https://openalex.org/W2082804426","https://openalex.org/W2086693236","https://openalex.org/W2090043910","https://openalex.org/W2093672783","https://openalex.org/W2166224681","https://openalex.org/W2318772898","https://openalex.org/W2605539363","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2061950089","https://openalex.org/W2732006578","https://openalex.org/W60148058","https://openalex.org/W2440858790","https://openalex.org/W7165392644","https://openalex.org/W4321429561","https://openalex.org/W2576720322","https://openalex.org/W2110045426","https://openalex.org/W2378213975","https://openalex.org/W4288065204"],"abstract_inverted_index":{"In":[0,138,248],"most":[1,163],"reported":[2],"series,":[3],"less":[4,257,267,297,307],"than":[5,234,246,258,268,298,308],"20%":[6,195],"of":[7,19,36,46,53,69,115,125,128,148,176,187,196,203,209,230,237,254,261,301],"patients":[8,38,62,97,119,178,232,252,294],"with":[9,50,63,239,264,295,304],"primary":[10],"cerebral":[11],"non-Hodgkin's":[12],"lymphoma":[13],"(PCL)":[14],"and":[15,23,65,82,103,174,184,214,219,276,281],"no":[16,66],"known":[17,67],"cause":[18,68],"immunodepression":[20],"are":[21],"alive":[22],"disease-free":[24],"5":[25,51,215,277],"years":[26,76,216,236,260,278,300],"after":[27,112,179],"the":[28,34,83,113,116,122,141,162,177,180,197,206,210,228,249,270],"initial":[29],"diagnosis.":[30],"Whether":[31],"chemotherapy":[32,54],"improves":[33],"outcome":[35],"these":[37],"remains":[39],"unclear.":[40],"We":[41],"report":[42],"a":[43,47,100,107,200,288],"pilot":[44],"study":[45],"protocol":[48,286],"(C5R)":[49],"courses":[52,186],"followed":[55],"by":[56],"cranial":[57],"radiotherapy":[58],"in":[59,93,121,170,194,227,292],"25":[60],"adult":[61],"PCL":[64,296],"immunodepression.":[70],"The":[71,222,284],"median":[72,84,201],"age":[73,238,262,302],"was":[74,87,161],"51":[75],"(range,":[77,89],"16":[78],"to":[79,91],"70":[80],"years)":[81],"performance":[85],"status":[86],"2":[88,213,275],"1":[90,110],"4)":[92],"this":[94,255],"series.":[95],"Fourteen":[96],"(56%)":[98],"achieved":[99,106],"complete":[101],"response":[102,109],"4":[104,191,223],"(16%)":[105],"partial":[108],"month":[111,124],"completion":[114],"treatment.":[117],"Four":[118],"died":[120],"first":[123],"treatment":[126,142],"because":[127,147],"progression":[129],"(n":[130,135,151,157],"=":[131,136,152,158],"1)":[132,153],"or":[133,154,263,303],"toxicity":[134],"3).":[137],"3":[139],"patients,":[140],"could":[143],"not":[144],"be":[145],"performed":[146],"patient":[149],"refusal":[150],"severe":[155],"infections":[156],"2).":[159],"Myelosuppression":[160],"frequent":[164],"side":[165],"effect;":[166],"febrile":[167],"neutropenia":[168],"occurred":[169,193,226],"96%,":[171],"89%,":[172],"69%,":[173],"74%":[175],"second,":[181],"third,":[182],"fourth,":[183],"fifth":[185],"chemotherapy,":[188],"respectively.":[189,221,283],"Grade":[190],"thrombocytopenia":[192],"patients.":[198],"With":[199],"follow-up":[202],"24":[204],"months,":[205],"projected":[207,271],"survival":[208,273],"group":[211],"at":[212,274],"is":[217,279,287],"70%":[218],"56%,":[220],"early":[224],"deaths":[225],"subgroup":[229],"6":[231],"greater":[233,245],"60":[235],"an":[240,265,305],"international":[241],"prognostic":[242],"index":[243],"(IPI)":[244],"3.":[247],"19":[250],"remaining":[251],"(76%":[253],"series)":[256],"61":[259,299],"IPI":[266,306],"4,":[269],"overall":[272],"88%":[280],"70%,":[282],"C5R":[285],"highly":[289],"efficient":[290],"regimen":[291],"nonimmunosuppressed":[293],"4.":[309]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
