{"id":"https://openalex.org/W1480100581","doi":"https://doi.org/10.1016/j.molcel.2015.04.021","title":"Defining the Metabolome: Size, Flux, and Regulation","display_name":"Defining the Metabolome: Size, Flux, and Regulation","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W1480100581","doi":"https://doi.org/10.1016/j.molcel.2015.04.021","mag":"1480100581","pmid":"https://pubmed.ncbi.nlm.nih.gov/26000853","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4831058"},"language":"en","primary_location":{"id":"doi:10.1016/j.molcel.2015.04.021","doi":"https://doi.org/10.1016/j.molcel.2015.04.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2015.04.021","pdf_url":"http://www.cell.com/article/S1097276515003032/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1097276515003032/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089920309","display_name":"Nicola Zamboni","orcid":"https://orcid.org/0000-0003-1271-1021","observed_orcids":["https://orcid.org/0000-0003-1271-1021"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255907","display_name":"Institute for Molecular Systems Biology","ror":"https://ror.org/03j5gm982","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255907"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Nicola Zamboni","raw_affiliation_strings":["Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland. Electronic address: zamboni@imsb.biol.ethz.ch","Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland. Electronic address: zamboni@imsb.biol.ethz.ch","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907"]},{"raw_affiliation_string":"Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065981856","display_name":"Alan Saghatelian","orcid":"https://orcid.org/0000-0002-0427-563X","observed_orcids":["https://orcid.org/0000-0002-0427-563X"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Saghatelian","raw_affiliation_strings":["Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: asaghatelian@salk.edu","Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: asaghatelian@salk.edu","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027513211","display_name":"Gary J. Patti","orcid":"https://orcid.org/0000-0002-3748-6193","observed_orcids":["https://orcid.org/0000-0002-3748-6193"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary\u00a0J. Patti","raw_affiliation_strings":["Department of Chemistry and Department of Medicine, Washington University, St. Louis, MO 63130, USA. Electronic address: gjpattij@wustl.edu","Department of Chemistry and Department of Medicine, Washington University, St. Louis, MO 63130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Department of Medicine, Washington University, St. Louis, MO 63130, USA. Electronic address: gjpattij@wustl.edu","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Chemistry and Department of Medicine, Washington University, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027513211","https://openalex.org/A5065981856","https://openalex.org/A5089920309"],"corresponding_institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I204465549","https://openalex.org/I35440088","https://openalex.org/I4405255907"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":3.2174,"has_fulltext":false,"cited_by_count":299,"citation_normalized_percentile":{"value":0.95342338,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"58","issue":"4","first_page":"699","last_page":"706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0560000017285347,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolome","display_name":"metabolome","score":0.7829999923706055},{"id":"https://openalex.org/keywords/untargeted-metabolomics","display_name":"untargeted metabolomics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"metabolic flux analysis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/stable-isotopes","display_name":"stable isotopes","score":0.9070000052452087},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9275710582733154},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.9164983034133911},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5779611468315125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4957784116268158},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.3054543137550354},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26896989345550537},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.molcel.2015.04.021","doi":"https://doi.org/10.1016/j.molcel.2015.04.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2015.04.021","pdf_url":"http://www.cell.com/article/S1097276515003032/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},{"id":"pmid:26000853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26000853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cell","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3837107","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4831058","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4831058","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4831058","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.molcel.2015.04.021","doi":"https://doi.org/10.1016/j.molcel.2015.04.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molcel.2015.04.021","pdf_url":"http://www.cell.com/article/S1097276515003032/pdf","source":{"id":"https://openalex.org/S156208185","display_name":"Molecular Cell","issn_l":"1097-2765","issn":["1097-2765","1097-4164"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G528059415","display_name":"DEVELOPING THE UNTARGETED METABOLOMIC WORKFLOW FOR HIGH-THROUGHPUT ANALYSES","funder_award_id":"R01ES022181","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1480100581.pdf"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W143096088","https://openalex.org/W1520503489","https://openalex.org/W1965920457","https://openalex.org/W1979547209","https://openalex.org/W1986562177","https://openalex.org/W1993399595","https://openalex.org/W1997062226","https://openalex.org/W2001077777","https://openalex.org/W2006100287","https://openalex.org/W2006315039","https://openalex.org/W2007892976","https://openalex.org/W2011330793","https://openalex.org/W2014988241","https://openalex.org/W2017035524","https://openalex.org/W2026170688","https://openalex.org/W2026724911","https://openalex.org/W2030933109","https://openalex.org/W2040199573","https://openalex.org/W2044565982","https://openalex.org/W2046965677","https://openalex.org/W2047867594","https://openalex.org/W2053307994","https://openalex.org/W2053385401","https://openalex.org/W2057862944","https://openalex.org/W2059327215","https://openalex.org/W2062870510","https://openalex.org/W2067220774","https://openalex.org/W2069621804","https://openalex.org/W2072040767","https://openalex.org/W2080019362","https://openalex.org/W2080046774","https://openalex.org/W2080452140","https://openalex.org/W2087729559","https://openalex.org/W2095987251","https://openalex.org/W2113315423","https://openalex.org/W2122259188","https://openalex.org/W2126304335","https://openalex.org/W2126524529","https://openalex.org/W2128817061","https://openalex.org/W2131094572","https://openalex.org/W2132218677","https://openalex.org/W2134138595","https://openalex.org/W2139464173","https://openalex.org/W2142117913","https://openalex.org/W2142726269","https://openalex.org/W2145063435","https://openalex.org/W2146095405","https://openalex.org/W2152560090","https://openalex.org/W2159482845","https://openalex.org/W2159901810","https://openalex.org/W2165431281","https://openalex.org/W2169137285","https://openalex.org/W2169156123","https://openalex.org/W2316741851","https://openalex.org/W4241560511"],"related_works":["https://openalex.org/W7170736120","https://openalex.org/W4319922480","https://openalex.org/W7095657615","https://openalex.org/W6998647877","https://openalex.org/W2549330647","https://openalex.org/W3140940852","https://openalex.org/W4249360821","https://openalex.org/W2187596482","https://openalex.org/W2710159465","https://openalex.org/W4246280703"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":43},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
