{"id":"https://openalex.org/W1479978566","doi":"https://doi.org/10.1016/j.bpj.2011.11.3999","title":"Structural and Mechanical Differences between Collagen Homo- and Heterotrimers: Relevance for the Molecular Origin of Brittle Bone Disease","display_name":"Structural and Mechanical Differences between Collagen Homo- and Heterotrimers: Relevance for the Molecular Origin of Brittle Bone Disease","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W1479978566","doi":"https://doi.org/10.1016/j.bpj.2011.11.3999","mag":"1479978566","pmid":"https://pubmed.ncbi.nlm.nih.gov/22325288","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3274792"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2011.11.3999","doi":"https://doi.org/10.1016/j.bpj.2011.11.3999","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.3999","pdf_url":"http://www.cell.com/article/S0006349511053471/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349511053471/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076940503","display_name":"Shu\u2010Wei Chang","orcid":"https://orcid.org/0000-0002-0195-6499","observed_orcids":["https://orcid.org/0000-0002-0195-6499"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu-Wei Chang","raw_affiliation_strings":["Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021075296","display_name":"Sandra J. Shefelbine","orcid":"https://orcid.org/0000-0002-4011-9044","observed_orcids":["https://orcid.org/0000-0002-4011-9044"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sandra\u00a0J. Shefelbine","raw_affiliation_strings":["Department of Bioengineering, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011504360","display_name":"Markus J. Buehler","orcid":"https://orcid.org/0000-0002-4173-9659","observed_orcids":["https://orcid.org/0000-0002-4173-9659"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Markus\u00a0J. Buehler","raw_affiliation_strings":["Center for Computational Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts","Center for Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts","Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Center for Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011504360"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":5.1992,"has_fulltext":true,"cited_by_count":130,"citation_normalized_percentile":{"value":0.9644656,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"102","issue":"3","first_page":"640","last_page":"648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.24560000002384186,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9800000190734863},{"id":"https://openalex.org/keywords/osteogenesis-imperfecta","display_name":"osteogenesis imperfecta","score":0.9269999861717224},{"id":"https://openalex.org/keywords/persistence-length","display_name":"persistence length","score":0.8740000128746033},{"id":"https://openalex.org/keywords/intermolecular-crosslinking","display_name":"intermolecular crosslinking","score":0.8510000109672546},{"id":"https://openalex.org/keywords/collagen-fibrils","display_name":"collagen fibrils","score":0.7260000109672546},{"id":"https://openalex.org/keywords/atomistic-simulation","display_name":"atomistic simulation","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.5501752495765686},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47840937972068787},{"id":"https://openalex.org/C136478896","wikidata":"https://www.wikidata.org/wiki/Q898288","display_name":"Brittleness","level":2,"score":0.44722995162010193},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.379432737827301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33934301137924194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2933090329170227},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.24805429577827454},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22792699933052063},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1037798523902893},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001847","descriptor_name":"Bone Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055595","descriptor_name":"Mechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.bpj.2011.11.3999","doi":"https://doi.org/10.1016/j.bpj.2011.11.3999","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.3999","pdf_url":"http://www.cell.com/article/S0006349511053471/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2566961","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3274792","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3274792","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3274792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmid:22325288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22325288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.453.4374","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.453.4374","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://web.mit.edu/mbuehler/www/papers/Biophysical_J_2012.pdf","raw_type":"text"},{"id":"pmh:oai:dspace.mit.edu:1721.1/91627","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/91627","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elsevier","raw_type":"Article"},{"id":"mag:1479978566","doi":null,"is_oa":false,"landing_page_url":"http://dspace.mit.edu/handle/1721.1/91627","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Elsevier eBooks","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2011.11.3999","doi":"https://doi.org/10.1016/j.bpj.2011.11.3999","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2011.11.3999","pdf_url":"http://www.cell.com/article/S0006349511053471/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1479978566.pdf","grobid_xml":"https://content.openalex.org/works/W1479978566.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1484001766","https://openalex.org/W1504222137","https://openalex.org/W1534337638","https://openalex.org/W1548689236","https://openalex.org/W1554925061","https://openalex.org/W1565820371","https://openalex.org/W1969489801","https://openalex.org/W1970416431","https://openalex.org/W1972353378","https://openalex.org/W1975249765","https://openalex.org/W1975443843","https://openalex.org/W1975449397","https://openalex.org/W1976818385","https://openalex.org/W1980281480","https://openalex.org/W1982754558","https://openalex.org/W1982956225","https://openalex.org/W1983571130","https://openalex.org/W1986247215","https://openalex.org/W1989418402","https://openalex.org/W1990336718","https://openalex.org/W1997630758","https://openalex.org/W1999479012","https://openalex.org/W2000621061","https://openalex.org/W2001233587","https://openalex.org/W2003988228","https://openalex.org/W2004212722","https://openalex.org/W2007616173","https://openalex.org/W2010081741","https://openalex.org/W2015022545","https://openalex.org/W2018549462","https://openalex.org/W2018868266","https://openalex.org/W2023617483","https://openalex.org/W2023739541","https://openalex.org/W2027342706","https://openalex.org/W2027408247","https://openalex.org/W2029667189","https://openalex.org/W2033060852","https://openalex.org/W2033275398","https://openalex.org/W2038226710","https://openalex.org/W2042555832","https://openalex.org/W2050055706","https://openalex.org/W2050060496","https://openalex.org/W2050765870","https://openalex.org/W2055076161","https://openalex.org/W2056244156","https://openalex.org/W2056660589","https://openalex.org/W2057852412","https://openalex.org/W2058792099","https://openalex.org/W2087514098","https://openalex.org/W2110799539","https://openalex.org/W2111801168","https://openalex.org/W2126703541","https://openalex.org/W2145914528","https://openalex.org/W2147529042","https://openalex.org/W2148839162","https://openalex.org/W2150780434","https://openalex.org/W2154387825","https://openalex.org/W2156564908","https://openalex.org/W2156871002","https://openalex.org/W2169685756","https://openalex.org/W2742303372","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4295905646","https://openalex.org/W7211989056","https://openalex.org/W2018557877","https://openalex.org/W2027342706","https://openalex.org/W1980281480","https://openalex.org/W67911317","https://openalex.org/W2056660589","https://openalex.org/W7160139072","https://openalex.org/W2509008394","https://openalex.org/W7099133109"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}