{"id":"https://openalex.org/W1479959677","doi":null,"title":"Iron-binding proteins and C-reactive protein in Nipple Aspirate Fluids: role of Iron-driven inflammation in breast cancer microenvironment?","display_name":"Iron-binding proteins and C-reactive protein in Nipple Aspirate Fluids: role of Iron-driven inflammation in breast cancer microenvironment?","publication_year":2010,"publication_date":"2010-10-30","ids":{"openalex":"https://openalex.org/W1479959677","mag":"1479959677","pmid":"https://pubmed.ncbi.nlm.nih.gov/21139810","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2981430"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2981430","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2981430","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2981430","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059218162","display_name":"Ferdinando Mannello","orcid":"https://orcid.org/0000-0001-8112-6139","observed_orcids":["https://orcid.org/0000-0001-8112-6139"]},"institutions":[{"id":"https://openalex.org/I190397597","display_name":"University of Urbino","ror":"https://ror.org/04q4kt073","country_code":"IT","type":"education","lineage":["https://openalex.org/I190397597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ferdinando Mannello","raw_affiliation_strings":["Department of Biomolecular Sciences, Section of Clinical Biochemistry, Unit of Cell Biology, University \"Carlo Bo\" Urbino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Sciences, Section of Clinical Biochemistry, Unit of Cell Biology, University \"Carlo Bo\" Urbino, Italy","institution_ids":["https://openalex.org/I190397597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014024754","display_name":"Gaetana A. Tonti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaetana A Tonti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Patrizia Simone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrizia Simone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025139304","display_name":"Daniela Ligi","orcid":"https://orcid.org/0000-0002-5546-8765","observed_orcids":["https://orcid.org/0000-0002-5546-8765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Ligi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056295139","display_name":"Virginia Medda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virginia Medda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1769,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79246568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"3","issue":"1","first_page":"100","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nipple-aspirate-fluid","display_name":"nipple aspirate fluid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/transferrin","display_name":"transferrin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/breast-microenvironment","display_name":"breast microenvironment","score":0.8220000267028809},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.5419999957084656},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.7250000238418579},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.7590000033378601},{"id":"https://openalex.org/keywords/breast-milk","display_name":"breast milk","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8109596371650696},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.627616286277771},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5694692134857178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5645502805709839},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.5608904361724854},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.47950679063796997},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4704626500606537},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4547807276248932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.453877329826355},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.43771857023239136},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4166867733001709},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4151134788990021},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.397578626871109},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38324111700057983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34870925545692444},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3472878336906433}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2981430","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2981430","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:21139810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21139810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:ora.uniurb.it:11576/2510924","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11576/2510924","pdf_url":null,"source":{"id":"https://openalex.org/S4377196377","display_name":"CINECA IRIS Institutional Research information system (University of Urbino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190397597","host_organization_name":"University of Urbino","host_organization_lineage":["https://openalex.org/I190397597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1479959677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21139810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2981430","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2981430","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W130206020","https://openalex.org/W169084348","https://openalex.org/W1544510740","https://openalex.org/W1624451393","https://openalex.org/W1703632053","https://openalex.org/W1965037168","https://openalex.org/W1969296748","https://openalex.org/W1970096539","https://openalex.org/W1972850698","https://openalex.org/W1973047537","https://openalex.org/W1974678207","https://openalex.org/W1979538859","https://openalex.org/W1985687310","https://openalex.org/W1986642570","https://openalex.org/W1987699028","https://openalex.org/W1990549321","https://openalex.org/W1993606165","https://openalex.org/W1997825352","https://openalex.org/W2003878414","https://openalex.org/W2006358233","https://openalex.org/W2008562162","https://openalex.org/W2010000042","https://openalex.org/W2016326711","https://openalex.org/W2018037572","https://openalex.org/W2018302726","https://openalex.org/W2028254493","https://openalex.org/W2040935952","https://openalex.org/W2049332203","https://openalex.org/W2051180209","https://openalex.org/W2067974370","https://openalex.org/W2077328361","https://openalex.org/W2082046910","https://openalex.org/W2099000927","https://openalex.org/W2099408048","https://openalex.org/W2102312730","https://openalex.org/W2104657191","https://openalex.org/W2108688501","https://openalex.org/W2120057023","https://openalex.org/W2123468376","https://openalex.org/W2130647322","https://openalex.org/W2131553129","https://openalex.org/W2135647666","https://openalex.org/W2153843568","https://openalex.org/W2154063848","https://openalex.org/W2158438458","https://openalex.org/W2158734599","https://openalex.org/W2161067768","https://openalex.org/W2163064788","https://openalex.org/W2165220060","https://openalex.org/W2167409896","https://openalex.org/W2168973734","https://openalex.org/W2172154235","https://openalex.org/W2258484145","https://openalex.org/W2409650923","https://openalex.org/W2412258129","https://openalex.org/W2412797429","https://openalex.org/W3145402682"],"related_works":["https://openalex.org/W1987699028","https://openalex.org/W1997825352","https://openalex.org/W2134685061","https://openalex.org/W2150502719","https://openalex.org/W3096429414","https://openalex.org/W2946380487","https://openalex.org/W4386200693","https://openalex.org/W2172458185","https://openalex.org/W4242945491","https://openalex.org/W1903403771"],"abstract_inverted_index":{"Breast":[0],"cancer,":[1,90],"a":[2,55],"worldwide":[3],"disease":[4],"with":[5],"increasing":[6],"incidence,":[7],"develops":[8],"from":[9,17,68,111,140],"ductal/lobular":[10],"epithelium.":[11],"Nipple":[12],"aspirate":[13],"fluid":[14,104],"(NAF),":[15],"secreted":[16],"the":[18,47,69,91,94,106,120,206,229],"breast":[19,31,65,87,107,115,216,241],"ducts":[20],"and":[21,34,73,80,89,113,125,136,175,189,210],"lobules,":[22],"can":[23],"be":[24],"analyzed":[25],"to":[26,46,98,178,228,236],"assess":[27],"metabolic":[28],"activity":[29],"in":[30,63,86,100,148,155,162,166,215,224,226],"microenvironment.":[32],"Premalignant":[33],"malignant":[35],"cell":[36],"alterations":[37],"may":[38,204,234],"produce":[39],"biochemical":[40],"signals":[41],"that":[42,71],"deliver":[43],"inflammatory":[44],"proteins":[45],"site.":[48],"C-reactive":[49],"protein":[50,53,77],"(CRP),":[51],"acute-phase":[52],"considered":[54],"prognostic":[56],"marker":[57],"of":[58,93,122,146,173,208,212,222,231],"inflammation,":[59],"is":[60,97],"frequently":[61],"over-expressed":[62],"invasive":[64],"carcinomas.":[66],"Starting":[67],"evidence":[70],"soluble":[72],"cell-bound":[74],"iron":[75,213,232],"binding":[76],"Ferritin":[78],"(FTN)":[79],"Transferrin":[81],"(TRF)":[82],"are":[83],"crucially":[84],"involved":[85],"inflammation":[88,209],"aim":[92],"present":[95],"study":[96],"analyze":[99],"NAF":[101,150,157,168,180,225],"(a":[102],"ductal":[103],"mirroring":[105],"microenvironment":[108],"noninvasively":[109],"collected":[110],"healthy":[112,141],"proven":[114],"cancer":[116,217,242],"affected":[117],"women,":[118],"n=38),":[119],"concentrations":[121],"CRP,":[123],"FTN":[124,176,188],"TRF":[126,174],"through":[127],"high":[128],"sensitive":[129],"immunoassays.":[130],"We":[131],"analysed":[132],"also":[133],"serum":[134],"(n=35)":[135],"milk":[137],"samples":[138],"(n=20)":[139],"subjects.":[142],"The":[143,219],"mean":[144],"level":[145],"CRP":[147,190,223],"Cancer":[149,167],"was":[151,200],"significantly":[152],"higher":[153,171,240],"than":[154],"NoCancer":[156,179],"(P":[158],"<":[159],"0.0001),":[160],"especially":[161],"postmenopausal":[163],"patients.":[164],"Moreover,":[165],"we":[169],"detected":[170],"levels":[172],"respect":[177],"(P<0.001).":[181],"A":[182],"highly":[183],"significant":[184,220],"positive":[185],"correlation":[186],"between":[187],"content":[191],"(Y=":[192],"2322x":[193],"+":[194],"6.196,":[195],"r(2)":[196],"=":[197],"0.651,":[198],"P<0.0001)":[199],"found.":[201],"These":[202],"data":[203],"support":[205],"involvement":[207],"deregulation":[211],"homeostasis":[214,233],"etio-pathogenesis.":[218],"accumulation":[221],"conjunction":[227],"disruption":[230],"help":[235],"identify":[237],"women":[238],"at":[239],"risk.":[243]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
