{"id":"https://openalex.org/W1479932344","doi":"https://doi.org/10.1016/s0889-1591(02)00005-3","title":"Questions raised by the cytokine hypothesis of depression","display_name":"Questions raised by the cytokine hypothesis of depression","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W1479932344","doi":"https://doi.org/10.1016/s0889-1591(02)00005-3","mag":"1479932344","pmid":"https://pubmed.ncbi.nlm.nih.gov/12401476"},"language":"en","primary_location":{"id":"doi:10.1016/s0889-1591(02)00005-3","doi":"https://doi.org/10.1016/s0889-1591(02)00005-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0889-1591(02)00005-3","pdf_url":null,"source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Renaud de Beaurepaire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Renaud de Beaurepaire","raw_affiliation_strings":["CH Paul Guiraud, 54, avenue de la R\u00e9publique, 94806 Villejuif, France. rdebeaurep@aol.com","C.H. Paul Guiraud, 54, avenue de la R\u00e9publique, 94806 Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CH Paul Guiraud, 54, avenue de la R\u00e9publique, 94806 Villejuif, France. rdebeaurep@aol.com","institution_ids":[]},{"raw_affiliation_string":"C.H. Paul Guiraud, 54, avenue de la R\u00e9publique, 94806 Villejuif, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5680,"currency":"USD","value_usd":5680},"apc_paid":null,"fwci":0.2542,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.07407407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"5","first_page":"610","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.746999979019165},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7260000109672546},{"id":"https://openalex.org/keywords/sensitization","display_name":"sensitization","score":0.9129999876022339},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cognition","display_name":"cognition","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.9660000205039978},{"id":"https://openalex.org/keywords/monoamines","display_name":"monoamines","score":0.8339999914169312},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5979323387145996},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5590643882751465},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.5552706122398376},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5244170427322388},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.4235374331474304},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41972625255584717},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.36465007066726685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3229024410247803},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2592408061027527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.155636727809906},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.11747962236404419},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0877537727355957},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015306","descriptor_name":"Biogenic Monoamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0889-1591(02)00005-3","doi":"https://doi.org/10.1016/s0889-1591(02)00005-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0889-1591(02)00005-3","pdf_url":null,"source":{"id":"https://openalex.org/S102243518","display_name":"Brain Behavior and Immunity","issn_l":"0889-1591","issn":["0889-1591","1090-2139"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, Behavior, and Immunity","raw_type":"journal-article"},{"id":"pmid:12401476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12401476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain, behavior, and immunity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W45362584","https://openalex.org/W160111197","https://openalex.org/W206192302","https://openalex.org/W302587024","https://openalex.org/W1519245788","https://openalex.org/W1572595425","https://openalex.org/W1665095741","https://openalex.org/W1913538625","https://openalex.org/W1981098067","https://openalex.org/W1989060739","https://openalex.org/W1990913499","https://openalex.org/W1998153328","https://openalex.org/W1999540283","https://openalex.org/W2010523730","https://openalex.org/W2036385709","https://openalex.org/W2039846441","https://openalex.org/W2045534711","https://openalex.org/W2052450659","https://openalex.org/W2061730652","https://openalex.org/W2063650882","https://openalex.org/W2075557040","https://openalex.org/W2077326058","https://openalex.org/W2077906219","https://openalex.org/W2085264188","https://openalex.org/W2086124484","https://openalex.org/W2089115079","https://openalex.org/W2089390421","https://openalex.org/W2121878996","https://openalex.org/W2135947496","https://openalex.org/W2145426948","https://openalex.org/W2278747333","https://openalex.org/W2283005973"],"related_works":["https://openalex.org/W3178873716","https://openalex.org/W1481765194","https://openalex.org/W2521723708","https://openalex.org/W2057670077","https://openalex.org/W3116367275","https://openalex.org/W2073957455","https://openalex.org/W2011684192","https://openalex.org/W2073296371","https://openalex.org/W2049361817","https://openalex.org/W2117633457"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
