{"id":"https://openalex.org/W1479924008","doi":"https://doi.org/10.11150/kansenshogakuzasshi1970.76.432","title":"The Usefulness of Human Lung Embryonal Fibroblast Cells (MRC-5) for Isolation of Enteroviruses and Adenoviruses","display_name":"The Usefulness of Human Lung Embryonal Fibroblast Cells (MRC-5) for Isolation of Enteroviruses and Adenoviruses","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1479924008","doi":"https://doi.org/10.11150/kansenshogakuzasshi1970.76.432","mag":"1479924008","pmid":"https://pubmed.ncbi.nlm.nih.gov/12136651"},"language":"ja","primary_location":{"id":"doi:10.11150/kansenshogakuzasshi1970.76.432","doi":"https://doi.org/10.11150/kansenshogakuzasshi1970.76.432","is_oa":true,"landing_page_url":"https://doi.org/10.11150/kansenshogakuzasshi1970.76.432","pdf_url":"https://www.jstage.jst.go.jp/article/kansenshogakuzasshi1970/76/6/76_6_432/_pdf","source":{"id":"https://openalex.org/S4210176383","display_name":"Kansenshogaku zasshi","issn_l":"0387-5911","issn":["0387-5911","1884-569X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Japanese Association for Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/kansenshogakuzasshi1970/76/6/76_6_432/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103746612","display_name":"Michiyo Shinohara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283390","display_name":"Saitama Prefectural Institute of Public Health","ror":"https://ror.org/01jvz9590","country_code":"JP","type":"government","lineage":["https://openalex.org/I2799799709","https://openalex.org/I4405283390"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiyo SHINOHARA","raw_affiliation_strings":["\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240","institution_ids":["https://openalex.org/I4405283390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110711012","display_name":"Kazue Uchida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283390","display_name":"Saitama Prefectural Institute of Public Health","ror":"https://ror.org/01jvz9590","country_code":"JP","type":"government","lineage":["https://openalex.org/I2799799709","https://openalex.org/I4405283390"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazue UCHIDA","raw_affiliation_strings":["\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240","institution_ids":["https://openalex.org/I4405283390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002004827","display_name":"Shin-ichi Shimada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283390","display_name":"Saitama Prefectural Institute of Public Health","ror":"https://ror.org/01jvz9590","country_code":"JP","type":"government","lineage":["https://openalex.org/I2799799709","https://openalex.org/I4405283390"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-ichi SHIMADA","raw_affiliation_strings":["\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240","institution_ids":["https://openalex.org/I4405283390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023928581","display_name":"Yukari Segawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283390","display_name":"Saitama Prefectural Institute of Public Health","ror":"https://ror.org/01jvz9590","country_code":"JP","type":"government","lineage":["https://openalex.org/I2799799709","https://openalex.org/I4405283390"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukari SEGAWA","raw_affiliation_strings":["\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240","institution_ids":["https://openalex.org/I4405283390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112169687","display_name":"Yoshifumi Hirose","orcid":"https://orcid.org/0009-0001-0969-549X","observed_orcids":["https://orcid.org/0009-0001-0969-549X"]},"institutions":[{"id":"https://openalex.org/I4405283390","display_name":"Saitama Prefectural Institute of Public Health","ror":"https://ror.org/01jvz9590","country_code":"JP","type":"government","lineage":["https://openalex.org/I2799799709","https://openalex.org/I4405283390"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshifumi HIROSE","raw_affiliation_strings":["\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u57fc\u7389\u770c\u885b\u751f\u7814\u7a76\u6240","institution_ids":["https://openalex.org/I4405283390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405283390"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.08520139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"76","issue":"6","first_page":"432","last_page":"438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrc-5-cells","display_name":"MRC-5 cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/human-embryonic-lung-fibroblasts","display_name":"human embryonic lung fibroblasts","score":0.8730000257492065},{"id":"https://openalex.org/keywords/virus-isolation","display_name":"virus isolation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/enterovirus","display_name":"enterovirus","score":0.9330000281333923},{"id":"https://openalex.org/keywords/adenovirus","display_name":"adenovirus","score":0.996999979019165},{"id":"https://openalex.org/keywords/coxsackievirus-a16","display_name":"coxsackievirus A16","score":0.9380000233650208},{"id":"https://openalex.org/keywords/enterovirus-71","display_name":"enterovirus 71","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cell-line-comparison","display_name":"cell line comparison","score":0.6729999780654907},{"id":"https://openalex.org/keywords/clinical-samples","display_name":"clinical samples","score":0.6159999966621399},{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.6309999823570251},{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.9150000214576721},{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.41600000858306885},{"id":"https://openalex.org/keywords/cell-culture-medium","display_name":"cell culture media","score":0.3720000088214874},{"id":"https://openalex.org/keywords/saitama-prefecture","display_name":"Saitama Prefecture","score":0.6740000247955322},{"id":"https://openalex.org/keywords/viral-surveillance","display_name":"viral surveillance","score":0.3370000123977661},{"id":"https://openalex.org/keywords/adenovirus-type-3","display_name":"adenovirus type 3","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7956619262695312},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.7189804911613464},{"id":"https://openalex.org/C2777888124","wikidata":"https://www.wikidata.org/wiki/Q519796","display_name":"Enterovirus","level":3,"score":0.7040442824363708},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6561884880065918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6556656956672668},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5447916984558105},{"id":"https://openalex.org/C2778889330","wikidata":"https://www.wikidata.org/wiki/Q1636618","display_name":"Enterovirus 71","level":4,"score":0.5246265530586243},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.4417249858379364},{"id":"https://openalex.org/C2775996393","wikidata":"https://www.wikidata.org/wiki/Q1149147","display_name":"Cytopathic effect","level":3,"score":0.42725181579589844},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3589497208595276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004770","descriptor_name":"Enterovirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.11150/kansenshogakuzasshi1970.76.432","doi":"https://doi.org/10.11150/kansenshogakuzasshi1970.76.432","is_oa":true,"landing_page_url":"https://doi.org/10.11150/kansenshogakuzasshi1970.76.432","pdf_url":"https://www.jstage.jst.go.jp/article/kansenshogakuzasshi1970/76/6/76_6_432/_pdf","source":{"id":"https://openalex.org/S4210176383","display_name":"Kansenshogaku zasshi","issn_l":"0387-5911","issn":["0387-5911","1884-569X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Japanese Association for Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:12136651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12136651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.11150/kansenshogakuzasshi1970.76.432","doi":"https://doi.org/10.11150/kansenshogakuzasshi1970.76.432","is_oa":true,"landing_page_url":"https://doi.org/10.11150/kansenshogakuzasshi1970.76.432","pdf_url":"https://www.jstage.jst.go.jp/article/kansenshogakuzasshi1970/76/6/76_6_432/_pdf","source":{"id":"https://openalex.org/S4210176383","display_name":"Kansenshogaku zasshi","issn_l":"0387-5911","issn":["0387-5911","1884-569X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Japanese Association for Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1479924008.pdf","grobid_xml":"https://content.openalex.org/works/W1479924008.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1549064169","https://openalex.org/W1972578988","https://openalex.org/W1990452786","https://openalex.org/W2004772472","https://openalex.org/W2011813238","https://openalex.org/W2064149798","https://openalex.org/W2109382426","https://openalex.org/W2142340463","https://openalex.org/W2155238498","https://openalex.org/W2160157197","https://openalex.org/W2169760405","https://openalex.org/W2418618394","https://openalex.org/W2423574599"],"related_works":["https://openalex.org/W2005264698","https://openalex.org/W2045929206","https://openalex.org/W2413939854","https://openalex.org/W1899552912","https://openalex.org/W1664851663","https://openalex.org/W1500339341","https://openalex.org/W152691122","https://openalex.org/W2155238498","https://openalex.org/W2130248751","https://openalex.org/W2142340463"],"abstract_inverted_index":{"Although":[0],"various":[1,102],"cell":[2,31,116],"lines":[3,32,117],"have":[4,23],"been":[5,24],"used":[6,362],"for":[7,48,101,105,135,219,326,364],"virus":[8,13,174,193,212,223,230,278,365,369],"isolation,":[9,366],"few":[10,221,302],"study":[11],"of":[12,50,57,81,91,98,109,122,137,145,153,191,247,275],"isolation":[14,49,136,152,273],"using":[15,115,341],"MRC-5":[16,28,95,130,166,284,313,343,360],"cell,":[17],"a":[18,107,180,220,301],"human":[19],"embryonic":[20],"lung":[21],"fibroblasts,":[22],"reported":[25],"in":[26,65,76,128,151,156,239,252,260,279,300,304,310,340],"Japan.":[27],"and":[29,41,43,63,71,87,120,140,143,160,176,184,189,195,202,204,208,232,241,254,283,324,329,350,373],"other":[30,147,336],"(Caco-2,":[33],"Vero,":[34],"RD-18s,":[35],"LLC-MK2,":[36],"HeLa,":[37],"MDCK,":[38],"FL,":[39],"B95a":[40],"HMV-II),":[42],"suckling":[44],"mouse":[45],"were":[46,74,85,93,113,126,235,250,344],"compared":[47],"viruses":[51,155,249],"from":[52,61,375],"clinical":[53,376],"specimens.":[54,377],"A":[55,79],"total":[56,80,108],"3,284":[58],"specimens,":[59],"collected":[60],"clinics":[62],"hospitals":[64],"Saitama":[66],"Prefecture":[67],"between":[68],"July":[69],"1997":[70],"August":[72],"2001,":[73],"inoculated":[75],"these":[77,92,154],"cells.":[78,148],"1,252":[82],"viral":[83,89,111,124],"strains":[84,90,112,125,246],"isolated":[86,114,127,236,251,259],"1,190":[88],"identified.":[94],"detected":[96,187,200,206,299],"209":[97],"specimens":[99],"positive":[100],"viruses.":[103],"As":[104],"adenovirus,":[106],"132":[110,123],"described":[118],"above,":[119],"100":[121],"MRC-5.":[129,261,294],"showed":[131,164,285],"the":[132,267,296,321,335,338,342,346,352,359],"highest":[133],"sensitivity":[134,150,182],"adenovirus":[138],"3":[139],"7":[141],"(79.1%":[142],"100%)":[144],"all":[146],"The":[149,272,312],"HeLa":[157],"was":[158,215,258,263,281,288,298,307,332,348,355,361],"58.1%":[159],"50.0%,":[161],"respectively.":[162,210],"It":[163,262],"that":[165,345,351],"is":[167,314],"able":[168],"to":[169,266,291,316],"isolate":[170],"enterovirus,":[171],"especially":[172,367],"coxsackie":[173,192,222,229,368],"A16":[175,194,231],"enterovirus":[177,196,233,371],"71":[178,197,234,372],"with":[179],"high":[181,289],"(85.7%":[183],"73.7%).":[185],"RD-18s":[186],"35.7%":[188],"26.3%":[190],"isolates,":[198],"LLC-MK2":[199],"60.7%":[201],"47.4%,":[203],"Vero":[205,280,292],"48.6%":[207],"52.6%,":[209],"Coxsackie":[211],"B":[213,224],"group":[214],"not":[216],"isolated,":[217],"except":[218,228],"5":[225],"strains.":[226],"Enteroviruses":[227],"more":[237],"frequently":[238],"Caco-2":[240],"RD-18s.":[242],"Seven":[243],"hundred":[244],"thirteen":[245],"influenza":[248],"MDCK":[253],"Caco-2,":[255],"but":[256],"none":[257],"probably":[264],"due":[265],"maintenance":[268,322],"medium":[269,323],"without":[270,319],"trypsin.":[271],"rate":[274],"herpes":[276],"simplex":[277],"88.9%":[282],"77.8%,":[286],"it":[287,306],"secondary":[290],"by":[293],"However,":[295,358],"CPE":[297,331],"days":[303],"MRC-5,":[305],"earlier":[308],"than":[309],"Vero.":[311],"possible":[315],"be":[317],"maintained":[318],"changing":[320],"passaged":[325],"2":[327],"weeks,":[328],"clear":[330],"observed.":[333],"On":[334],"hand,":[337],"disadvantages":[339],"passage":[347],"limited":[349],"split":[353],"ratio":[354],"only":[356],"1:2.":[357],"successfully":[363],"A16,":[370],"adenoviruses,":[374]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
