{"id":"https://openalex.org/W147803927","doi":null,"title":"Development of Novel AHR Antagonists","display_name":"Development of Novel AHR Antagonists","publication_year":2016,"publication_date":"2016-10-04","ids":{"openalex":"https://openalex.org/W147803927","mag":"147803927"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1106","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/103","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1106&context=gradschool_diss","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1106&context=gradschool_diss","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034892855","display_name":"Hyosung Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hyosung Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034892855"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":5.403e-05,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ahr-antagonists","display_name":"AhR antagonists","score":0.996999979019165},{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.9039999842643738},{"id":"https://openalex.org/keywords/apigenin","display_name":"apigenin","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ch223191","display_name":"CH223191","score":0.921999990940094},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.652999997138977},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ahr-signaling","display_name":"AhR signaling","score":0.5260000228881836},{"id":"https://openalex.org/keywords/structure-activity-optimization","display_name":"structure-activity optimization","score":0.6669999957084656},{"id":"https://openalex.org/keywords/positional-scanning","display_name":"positional scanning","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26654088497161865}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1106","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/103","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1106&context=gradschool_diss","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},{"id":"mag:147803927","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1106&context=gradschool_diss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1106","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/103","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1106&context=gradschool_diss","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W147803927.pdf","grobid_xml":"https://content.openalex.org/works/W147803927.grobid-xml"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W4705614","https://openalex.org/W72964011","https://openalex.org/W78056149","https://openalex.org/W94341715","https://openalex.org/W183908616","https://openalex.org/W189905895","https://openalex.org/W1498903889","https://openalex.org/W1521762620","https://openalex.org/W1531242992","https://openalex.org/W1544237631","https://openalex.org/W1547130031","https://openalex.org/W1567276231","https://openalex.org/W1567658740","https://openalex.org/W1591714400","https://openalex.org/W1860035717","https://openalex.org/W1896031554","https://openalex.org/W1901192183","https://openalex.org/W1935479846","https://openalex.org/W1961530921","https://openalex.org/W1965407474","https://openalex.org/W1969042227","https://openalex.org/W1969682160","https://openalex.org/W1971288812","https://openalex.org/W1973407849","https://openalex.org/W1973705667","https://openalex.org/W1974571230","https://openalex.org/W1975124499","https://openalex.org/W1975309175","https://openalex.org/W1975653258","https://openalex.org/W1976720178","https://openalex.org/W1977089984","https://openalex.org/W1983938442","https://openalex.org/W1985754063","https://openalex.org/W1986321253","https://openalex.org/W1989060543","https://openalex.org/W1990260467","https://openalex.org/W1990874048","https://openalex.org/W1991817880","https://openalex.org/W1992015519","https://openalex.org/W1993929723","https://openalex.org/W1998148780","https://openalex.org/W1998725768","https://openalex.org/W2000917514","https://openalex.org/W2002062079","https://openalex.org/W2003143426","https://openalex.org/W2007925775","https://openalex.org/W2010255001","https://openalex.org/W2011821806","https://openalex.org/W2013472109","https://openalex.org/W2019103072","https://openalex.org/W2020194591","https://openalex.org/W2020873521","https://openalex.org/W2021730934","https://openalex.org/W2022394817","https://openalex.org/W2023886403","https://openalex.org/W2024408959","https://openalex.org/W2025031463","https://openalex.org/W2026576106","https://openalex.org/W2027175206","https://openalex.org/W2027487946","https://openalex.org/W2029588268","https://openalex.org/W2030005694","https://openalex.org/W2030159438","https://openalex.org/W2033883932","https://openalex.org/W2038743591","https://openalex.org/W2039389146","https://openalex.org/W2041381136","https://openalex.org/W2042311100","https://openalex.org/W2043526119","https://openalex.org/W2045768631","https://openalex.org/W2048443173","https://openalex.org/W2048695976","https://openalex.org/W2050244937","https://openalex.org/W2051726425","https://openalex.org/W2052268618","https://openalex.org/W2052755516","https://openalex.org/W2054861419","https://openalex.org/W2057415024","https://openalex.org/W2057517652","https://openalex.org/W2057728329","https://openalex.org/W2058509770","https://openalex.org/W2059618194","https://openalex.org/W2059759973","https://openalex.org/W2062318487","https://openalex.org/W2064209430","https://openalex.org/W2067541125","https://openalex.org/W2067724662","https://openalex.org/W2070165132","https://openalex.org/W2071120121","https://openalex.org/W2072056842","https://openalex.org/W2072438213","https://openalex.org/W2075679933","https://openalex.org/W2075794433","https://openalex.org/W2077462800","https://openalex.org/W2077622468","https://openalex.org/W2078540269","https://openalex.org/W2081538782","https://openalex.org/W2083469632","https://openalex.org/W2084416116","https://openalex.org/W2087332917","https://openalex.org/W2087953945","https://openalex.org/W2090939833","https://openalex.org/W2091081324","https://openalex.org/W2091726431","https://openalex.org/W2091940864","https://openalex.org/W2093776019","https://openalex.org/W2094298387","https://openalex.org/W2103171042","https://openalex.org/W2103575848","https://openalex.org/W2104442846","https://openalex.org/W2104794408","https://openalex.org/W2105271234","https://openalex.org/W2109115330","https://openalex.org/W2119912258","https://openalex.org/W2122305079","https://openalex.org/W2122604442","https://openalex.org/W2124259311","https://openalex.org/W2124683851","https://openalex.org/W2127678138","https://openalex.org/W2131441324","https://openalex.org/W2132965659","https://openalex.org/W2135145833","https://openalex.org/W2139543010","https://openalex.org/W2150211787","https://openalex.org/W2150950415","https://openalex.org/W2151197941","https://openalex.org/W2151332880","https://openalex.org/W2151683271","https://openalex.org/W2153495879","https://openalex.org/W2156319617","https://openalex.org/W2159304791","https://openalex.org/W2161831252","https://openalex.org/W2163212976","https://openalex.org/W2163752139","https://openalex.org/W2165627850","https://openalex.org/W2167970552","https://openalex.org/W2170457291","https://openalex.org/W2318148969","https://openalex.org/W2336135962","https://openalex.org/W2336672860","https://openalex.org/W2399816391","https://openalex.org/W2462543596"],"related_works":["https://openalex.org/W3131113492","https://openalex.org/W2104442846","https://openalex.org/W2112754168","https://openalex.org/W2052268618","https://openalex.org/W2290388963","https://openalex.org/W4411051368","https://openalex.org/W4401951279","https://openalex.org/W7163394586","https://openalex.org/W2583990785","https://openalex.org/W2169417565"],"abstract_inverted_index":{"Aryl":[0],"hydrocarbon":[1],"receptor":[2],"(AHR)":[3],"is":[4,20,58,93,111],"a":[5,27,62,89,112,117,135,158,188],"sensor":[6],"protein,":[7],"activated":[8],"by":[9,43,78,197],"aromatic":[10],"chemical":[11],"species":[12],"for":[13,95,194,227,237],"transcriptionally":[14],"regulating":[15],"xenobiotic":[16],"metabolizing":[17],"enzymes.":[18],"AHR":[19,40,67,91,98,202,232],"also":[21],"known":[22],"to":[23,127,144,174],"be":[24,225],"involved":[25],"in":[26,53,152],"variety":[28],"of":[29,56,64,66,81,137,149,178,183],"pathogenesis":[30],"such":[31],"as":[32,100,102,157,234,236],"cancer,":[33],"diabetes":[34],"mellitus,":[35],"cirrhosis,":[36],"asthma,":[37],"etc.":[38],"The":[39,106,217],"signaling":[41],"induced":[42],"xenobiotics":[44,57],"has":[45],"been":[46,69,140],"intensively":[47],"studied":[48],"whereas":[49],"its":[50],"physiological":[51],"role":[52],"the":[54,79,84,97,124,147,163,176,181,207,228],"absence":[55],"poorly":[59],"understood.":[60],"Despite":[61],"number":[63,136],"ligands":[65],"have":[68,139],"reported":[70],"thus":[71],"far,":[72,134],"further":[73,229],"applications":[74],"are":[75],"still":[76],"hampered":[77],"lack":[80],"specificity":[82],"and/or":[83],"partially":[85],"agonistic":[86],"activity.":[87,216],"Thus,":[88],"pure":[90],"antagonist":[92],"needed":[94],"deciphering":[96],"cryptic":[99],"well":[101,235],"potential":[103],"therapeutic":[104,239],"agent.":[105],"Proteolysis":[107],"Targeting":[108],"Chimera":[109],"(PROTAC)":[110],"bi-functional":[113],"small":[114],"molecule":[115],"containing":[116],"ligand":[118],"and":[119,130,142,172,212,219],"proteolysis":[120,128],"inducer.":[121],"PROTAC":[122,138,156],"recruits":[123],"target":[125],"protein":[126,151],"machinery":[129],"elicits":[131],"proteolysis.":[132],"Thus":[133],"prepared":[141,171,211],"demonstrated":[143,173],"effectively":[145],"induce":[146,175],"degradation":[148,177],"targeted":[150],"cultured":[153],"cells,":[154],"validating":[155],"useful":[159],"research":[160],"tool.":[161],"In":[162],"present":[164],"study,":[165],"PROTACs":[166,204],"based":[167,205],"on":[168,206,231],"apigenin":[169],"was":[170,192],"AHR,":[179],"providing":[180],"proof":[182],"concept.":[184],"To":[185],"improve":[186],"activity,":[187],"synthetic":[189,220],"structure,":[190],"CH-223191,":[191],"optimized":[193],"antagonistic":[195],"activity":[196],"positional":[198],"scanning":[199],"identifying":[200],"several":[201],"antagonists.":[203],"optimal":[208],"structure":[209],"were":[210],"assessed":[213],"their":[214],"biological":[215],"products":[218],"scheme":[221],"described":[222],"hereby":[223],"will":[224],"helpful":[226],"understanding":[230],"biology":[233],"developing":[238],"agents":[240],"targeting":[241],"AHR.":[242]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}