{"id":"https://openalex.org/W14752674","doi":"https://doi.org/10.1042/cs0790457","title":"Effect of Infused Branched-Chain Amino Acids on Muscle and Whole-Body Amino Acid Metabolism in Man","display_name":"Effect of Infused Branched-Chain Amino Acids on Muscle and Whole-Body Amino Acid Metabolism in Man","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W14752674","doi":"https://doi.org/10.1042/cs0790457","mag":"14752674","pmid":"https://pubmed.ncbi.nlm.nih.gov/2174312"},"language":"en","primary_location":{"id":"doi:10.1042/cs0790457","doi":"https://doi.org/10.1042/cs0790457","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0790457","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038931222","display_name":"Rita J. Louard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita J. Louard","raw_affiliation_strings":["Department of Internal Medicine, Section of Endocrinology and Metabolism, and General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Section of Endocrinology and Metabolism, and General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046840650","display_name":"Eugene J. Barrett","orcid":"https://orcid.org/0000-0003-0689-4044","observed_orcids":["https://orcid.org/0000-0003-0689-4044"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene J. Barrett","raw_affiliation_strings":["Department of Internal Medicine, Section of Endocrinology and Metabolism, and General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Section of Endocrinology and Metabolism, and General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111787739","display_name":"R. Gelfand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Gelfand","raw_affiliation_strings":["Department of Internal Medicine, Section of Endocrinology and Metabolism, and General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Section of Endocrinology and Metabolism, and General Clinical Research Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":7.0542,"has_fulltext":false,"cited_by_count":158,"citation_normalized_percentile":{"value":0.9735574,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"79","issue":"5","first_page":"457","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7950000166893005},{"id":"https://openalex.org/keywords/skeletal-muscle-proteolysis","display_name":"skeletal muscle proteolysis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/muscle-protein-synthesis","display_name":"muscle protein synthesis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/leucine-flux","display_name":"leucine flux","score":0.8379999995231628},{"id":"https://openalex.org/keywords/amino-acid-kinetics","display_name":"amino acid kinetics","score":0.6330000162124634},{"id":"https://openalex.org/keywords/branched-chain-keto-acids","display_name":"branched-chain keto acids","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.6661320924758911},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6598952412605286},{"id":"https://openalex.org/C2994280701","wikidata":"https://www.wikidata.org/wiki/Q4862551","display_name":"Amino acid metabolism","level":3,"score":0.6121244430541992},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.542222797870636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45997190475463867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3316408395767212}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000597","descriptor_name":"Amino Acids, Branched-Chain","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000597","descriptor_name":"Amino Acids, Branched-Chain","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005542","descriptor_name":"Forearm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/cs0790457","doi":"https://doi.org/10.1042/cs0790457","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0790457","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:2174312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2174312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science (London, England : 1979)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1270333399","display_name":null,"funder_award_id":"RR 125","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6185226841","display_name":"TRAINING PROGRAM IN CLINICAL INVESTIGATION","funder_award_id":"T32DK007476","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7056573617","display_name":"Regulation of skeletal muscle protein metabolism","funder_award_id":"R01DK038578","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W130625397","https://openalex.org/W288771554","https://openalex.org/W1538895195","https://openalex.org/W1549084754","https://openalex.org/W1555155027","https://openalex.org/W1876489238","https://openalex.org/W1966755400","https://openalex.org/W1978054795","https://openalex.org/W2007397474","https://openalex.org/W2053403873","https://openalex.org/W2063218086","https://openalex.org/W2070744500","https://openalex.org/W2085107463","https://openalex.org/W2092033643","https://openalex.org/W2124134528","https://openalex.org/W2239103220","https://openalex.org/W2291694257","https://openalex.org/W2418570153"],"related_works":["https://openalex.org/W1977870779","https://openalex.org/W2046956654","https://openalex.org/W2047976244","https://openalex.org/W2491222500","https://openalex.org/W2508534571","https://openalex.org/W44500097","https://openalex.org/W2239103220","https://openalex.org/W1909838045","https://openalex.org/W2311790557","https://openalex.org/W155998548"],"abstract_inverted_index":{"1.":[0],"Using":[1],"the":[2,16,211,274,313],"forearm":[3,117,174,220,225],"balance":[4,175],"method,":[5],"together":[6],"with":[7,136,169,203],"systemic":[8],"infusions":[9],"of":[10,18,44,73,102,176,206,230,239,260,263,276,316],"L-[ring-2,6-3H]phenylalanine":[11],"and":[12,25,58,116,142,178,218,223],"L-[1-14C]leucine,":[13],"we":[14],"examined":[15],"effects":[17],"infused":[19],"branched-chain":[20,45,54,63,108,128,180,199,240,251,267,291,300,306,317],"amino":[21,28,46,55,76,109,129,181,200,241,252,268,301,307,318],"acids":[22,47,182],"on":[23],"whole-body":[24,214],"skeletal":[26,256],"muscle":[27,231,257,281,299],"acid":[29,56,110,130,201,253,269,293,302,308],"kinetics":[30],"in":[31,52,62,70,139,213,219,248,273,280,290,298],"10":[32,36],"postabsorptive":[33],"normal":[34,249],"subjects;":[35],"control":[37],"subjects":[38],"received":[39],"only":[40],"saline.":[41],"2.":[42],"Infusion":[43],"caused":[48],"a":[49,59,158,185,190],"four-fold":[50],"rise":[51,61,212,262],"arterial":[53],"levels":[57,72,86,91],"two-fold":[60],"keto":[64,292],"acids;":[65],"significant":[66,166,204],"declines":[67],"were":[68,87],"observed":[69],"circulating":[71],"most":[74],"other":[75,179],"acids,":[77],"including":[78],"phenylalanine,":[79],"which":[80],"fell":[81],"by":[82,107,153,237,286],"34%.":[83],"Plasma":[84],"insulin":[85],"unchanged":[88],"from":[89,184],"basal":[90,186],"(8":[92],"+/-":[93],"1":[94],"mu-units/ml).":[95],"3.":[96],"Whole-body":[97],"phenylalanine":[98,118,226,287],"flux,":[99],"an":[100,228,296],"index":[101,229],"proteolysis,":[103],"was":[104,120,164,234],"significantly":[105],"suppressed":[106],"infusion":[111,131,238,254],"(P":[112,123,146,194],"less":[113,124,147,195],"than":[114,125,148,196],"0.002),":[115],"production":[119],"also":[121],"inhibited":[122],"0.03).":[126],"With":[127],"total":[132],"leucine":[133,144,155,177,208,216,221],"flux":[134],"rose,":[135],"marked":[137,191],"increments":[138],"both":[140],"oxidative":[141],"non-oxidative":[143,215],"disposal":[145,315],"0.001).":[149],"Proteolysis,":[150],"as":[151,284],"measured":[152,285],"endogenous":[154],"production,":[156],"showed":[157],"modest":[159],"12%":[160],"decrease,":[161],"although":[162],"this":[163],"not":[165,235],"when":[167],"compared":[168],"saline":[170],"controls.":[171],"The":[172,244],"net":[173,187,192],"changed":[183],"output":[188],"to":[189],"uptake":[193,222,270],"0.001)":[197],"during":[198],"infusion,":[202],"stimulation":[205],"local":[207,305],"disposal.":[209],"Despite":[210],"disposal,":[217,224,227,288],"protein":[232,282],"synthesis,":[233,283],"stimulated":[236],"acids.":[242,319],"4.":[243],"results":[245],"suggest":[246],"that":[247],"man":[250],"suppresses":[255],"proteolysis":[258],"independently":[259],"any":[261,277],"plasma":[264],"insulin.":[265],"Muscle":[266],"rose":[271],"dramatically":[272],"absence":[275],"apparent":[278],"increase":[279,297],"or":[289],"release.":[294],"Thus,":[295],"concentrations":[303],"and/or":[304],"oxidation":[309],"must":[310],"account":[311],"for":[312],"increased":[314]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
