{"id":"https://openalex.org/W1474655279","doi":null,"title":"Haemopoiesis, leukaemia & imatinib: c-fms, a novel target for small molecule inhibitor therapy.","display_name":"Haemopoiesis, leukaemia & imatinib: c-fms, a novel target for small molecule inhibitor therapy.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1474655279","mag":"1474655279"},"language":"en","primary_location":{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/37703","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/37703","pdf_url":"http://hdl.handle.net/2440/37703","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2440/37703","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059194699","display_name":"Andrea L. Dewar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrea L. Dewar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059194699"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-fms","display_name":"c-fms","score":0.7730000019073486},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/monocyte-macrophage-differentiation","display_name":"monocyte-to-macrophage differentiation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.4350000023841858},{"id":"https://openalex.org/keywords/cell-surface-markers","display_name":"cell surface markers","score":0.5199999809265137},{"id":"https://openalex.org/keywords/colony-assay","display_name":"colony assay","score":0.3659999966621399},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.7813478708267212},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.48448988795280457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47395893931388855},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45773911476135254},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40151387453079224},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3441293239593506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19177457690238953},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.16450896859169006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13670116662979126},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/37703","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/37703","pdf_url":"http://hdl.handle.net/2440/37703","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:1474655279","doi":null,"is_oa":false,"landing_page_url":"https://digital.library.adelaide.edu.au/dspace/bitstream/2440/37703/9/01front.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/37703","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/37703","pdf_url":"http://hdl.handle.net/2440/37703","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1474655279.pdf","grobid_xml":"https://content.openalex.org/works/W1474655279.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1508593718","https://openalex.org/W1587324932","https://openalex.org/W1994987603","https://openalex.org/W2048747827","https://openalex.org/W2048992492","https://openalex.org/W2077553619","https://openalex.org/W2083612980","https://openalex.org/W2086410992","https://openalex.org/W2165787335"],"related_works":["https://openalex.org/W2171405465","https://openalex.org/W2339731777","https://openalex.org/W2093635574","https://openalex.org/W1887685497","https://openalex.org/W4246097864","https://openalex.org/W2925020551","https://openalex.org/W4405849668","https://openalex.org/W1964698497","https://openalex.org/W2128499245","https://openalex.org/W6894278324"],"abstract_inverted_index":{"Understanding":[0],"the":[1,5,21,47,62,68,84,100,142,149,261],"factors":[2],"that":[3,83,190,273,322],"regulate":[4],"growth":[6,150,279],"and":[7,23,31,41,58,115,211,227,238,254,280,284,295,299,320,338,341],"differentiation":[8,24,85,101,205,237],"of":[9,25,43,64,70,75,86,102,111,144,151,168,185,191,200,203,224,229,235,245,260,286,293,318,329],"haemopoietic":[10],"stem":[11],"cells":[12,27,45,54,66,89,104,179],"(HSC)":[13],"remains":[14],"a":[15,135,270,315],"major":[16],"challenge.":[17],"In":[18],"this":[19,300],"study,":[20],"proliferation":[22,40,283],"CD34+":[26,88,103],"from":[28,55,105,166,180,352],"normal":[29,56,87,124,169,181],"donors":[30],"chronic":[32],"myeloid":[33],"leukaemia":[34],"(CML)":[35],"patients":[36,160],"was":[37,50,72,90,97,172,195,208,212,240,255,267,274,301],"compared.":[38],"The":[39,129,232],"entry":[42],"CML":[44,65,106,127,145],"into":[46],"cell":[48,79,121,271],"cycle":[49],"decreased":[51,215,305],"relative":[52],"to":[53,120,174,206,243,249,304],"donors,":[57,93],"greater":[59],"heterogeneity":[60],"in":[61,99,123,141,159],"phenotype":[63,76],"at":[67,197,290],"initiation":[69],"culture":[71],"observed.":[73],"Analysis":[74],"concomitant":[77],"with":[78,162,214,257],"division":[80,122],"also":[81,209,356],"demonstrated":[82],"consistent":[91,256],"between":[92],"while":[94],"marked":[95],"variability":[96],"observed":[98,158,196,210],"patients.":[107],"This":[108,265,335],"included":[109],"expression":[110],"CD13,":[112],"CD33,":[113],"CD38":[114],"HLA-DR,":[116],"which":[117],"were":[118,288],"linked":[119],"but":[125,188],"not":[126,189,241,302],"cells.":[128,153,231],"tyrosine":[130,246],"kinase":[131],"inhibitor,":[132],"imatinib,":[133,319],"is":[134,333],"novel":[136],"drug":[137],"displaying":[138],"promising":[139],"results":[140],"treatment":[143,328,354],"by":[146,252],"specifically":[147],"inhibiting":[148],"leukaemic":[152],"To":[154],"examine":[155],"whether":[156],"myelosuppression":[157],"treated":[161],"imatinib":[163,171,253,297,323,353],"may":[164],"arise":[165],"inhibition":[167,259],"haemopoiesis,":[170],"added":[173],"colony":[175],"assays":[176],"established":[177],"using":[178,269],"bone":[182],"marrow.":[183],"Suppression":[184],"monocyte/macrophage":[186,236],"growth,":[187],"eosinophils":[192],"or":[193],"neutrophils,":[194],"therapeutic":[198],"concentrations":[199],"imatinib.":[201],"Inhibition":[202],"monocytic":[204],"macrophages":[207],"associated":[213],"functional":[216],"capacity":[217],"such":[218,344],"as":[219,314,345],"altered":[220],"antigen":[221],"uptake,":[222],"production":[223],"proinflammatory":[225],"cytokines":[226],"stimulation":[228],"responder":[230],"specific":[233],"suppression":[234],"function":[239],"due":[242],"blockade":[244],"kinases":[247],"known":[248],"be":[250,325,357],"inhibited":[251,289],"an":[258,291],"M-CSF/c-fms":[262],"signalling":[263],"pathway.":[264],"hypothesis":[266],"tested":[268],"line":[272],"dependent":[275],"on":[276],"M-CSF":[277],"for":[278,327],"survival.":[281],"Cell":[282],"phosphorylation":[285],"c-fms":[287,306,313,332],"IC50":[292],"1.9\u03bcM":[294],"1.4\u03bcM":[296],"respectively":[298],"attributable":[303],"expression.":[307],"These":[308],"important":[309],"findings":[310],"therefore":[311],"identify":[312],"further":[316],"target":[317],"suggest":[321],"should":[324],"considered":[326],"diseases":[330],"where":[331],"implicated.":[334],"includes":[336],"breast":[337],"ovarian":[339],"cancer":[340],"inflammatory":[342],"conditions":[343],"rheumatoid":[346],"arthritis.":[347],"Potential":[348],"side":[349],"effects":[350],"resulting":[351],"must":[355],"considered.":[358]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}