{"id":"https://openalex.org/W1472944105","doi":null,"title":"Factors influencing alpha-crystallin association with phospholipid vesicles.","display_name":"Factors influencing alpha-crystallin association with phospholipid vesicles.","publication_year":2002,"publication_date":"2002-03-22","ids":{"openalex":"https://openalex.org/W1472944105","mag":"1472944105","pmid":"https://pubmed.ncbi.nlm.nih.gov/11951084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2902965"},"language":"en","primary_location":{"id":"pmid:11951084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11951084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2902965/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046791728","display_name":"Brian A. Cobb","orcid":"https://orcid.org/0000-0003-1055-2530","observed_orcids":["https://orcid.org/0000-0003-1055-2530"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A Cobb","raw_affiliation_strings":["Departments of Ophthalmology & Visual Sciences and Genetics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Ophthalmology & Visual Sciences and Genetics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004778896","display_name":"Jonathan Mark Petrash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Mark Petrash","raw_affiliation_strings":["Washington University \u2013 St Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University \u2013 St Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":0.1912,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.415288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":null,"first_page":"85","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-crystallin","display_name":"alpha-crystallin","score":1.0},{"id":"https://openalex.org/keywords/phospholipid-vesicles","display_name":"phospholipid vesicles","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lens-lipids","display_name":"lens lipids","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.7910000085830688},{"id":"https://openalex.org/keywords/lens-aging","display_name":"lens aging","score":0.765999972820282},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.8754376173019409},{"id":"https://openalex.org/C7263354","wikidata":"https://www.wikidata.org/wiki/Q2992167","display_name":"Crystallin","level":2,"score":0.6959976553916931},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.6479409337043762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4948849081993103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45852792263031006},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39114928245544434},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3885915279388428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3819505274295807}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11951084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11951084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2902965","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2902965/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"mag:1472944105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11951084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2902965","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2902965/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1964889935","display_name":"Diabetes Research & Training Center","funder_award_id":"P60DK020579","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3153079640","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY002687","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5780327333","display_name":"MOLECULAR INTERACTIONS OF ALPHA CRYSTALLINS IN THE EYE","funder_award_id":"F31EY006901","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000898797","display_name":"Diabetes Research Center","funder_award_id":"P30DK020579","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W100744059","https://openalex.org/W110513267","https://openalex.org/W1516901270","https://openalex.org/W1544668985","https://openalex.org/W1974511187","https://openalex.org/W1987657904","https://openalex.org/W1991591389","https://openalex.org/W2004538931","https://openalex.org/W2006684869","https://openalex.org/W2010772007","https://openalex.org/W2016592223","https://openalex.org/W2019270143","https://openalex.org/W2021866296","https://openalex.org/W2022693140","https://openalex.org/W2028737359","https://openalex.org/W2028907200","https://openalex.org/W2044031095","https://openalex.org/W2045683458","https://openalex.org/W2047496790","https://openalex.org/W2049078511","https://openalex.org/W2050771333","https://openalex.org/W2053081081","https://openalex.org/W2056295864","https://openalex.org/W2057363481","https://openalex.org/W2058494200","https://openalex.org/W2069993244","https://openalex.org/W2089541004","https://openalex.org/W2093123640","https://openalex.org/W2113707581","https://openalex.org/W2152311269","https://openalex.org/W2152409440","https://openalex.org/W2170762798"],"related_works":["https://openalex.org/W2020415786","https://openalex.org/W2047496790","https://openalex.org/W2089541004","https://openalex.org/W4297235605","https://openalex.org/W2112373577","https://openalex.org/W4319936481","https://openalex.org/W2093123640","https://openalex.org/W4211033942","https://openalex.org/W4211194293","https://openalex.org/W1516901270"],"abstract_inverted_index":{"PURPOSE:":[0],"Lens":[1],"lipids":[2,62],"undergo":[3],"a":[4,20,51,76,157,267,275],"number":[5],"of":[6,28,40,44,75,79,132,145,165,181,201,229,263,269,277,284,289],"changes":[7,59,65],"with":[8,34,37,93,114],"age,":[9],"including":[10],"an":[11],"overall":[12],"increase":[13],"in":[14,22,60,66,100,156,259],"phospholipid":[15,135],"acyl":[16,138],"chain":[17,139],"saturation":[18],"and":[19,36,56,63,81,96,109,143,168,190],"decrease":[21],"length.":[23],"In":[24,147],"addition,":[25,148],"the":[26,38,64,199,227,230,236,250,253,282],"amount":[27],"membrane":[29,68,243,261],"bound":[30,110],"alpha-crystallin":[31,67,98,111,150,172,182,202,221,242,264],"increases":[32],"dramatically":[33],"age":[35,55],"onset":[39],"cataract.":[41],"The":[42],"aim":[43],"this":[45],"study":[46],"was":[47,112,186],"to":[48,153,174,183,203,219,223],"determine":[49],"if":[50],"link":[52],"exists":[53],"between":[54],"cataract":[57],"associated":[58],"lens":[61,175,204],"association.":[69],"METHODS:":[70],"Protein-free":[71],"lipid":[72,83,128,133,270],"vesicles":[73,84,90,129,155,185],"composed":[74],"wide":[77],"variety":[78],"synthetic":[80],"lens-derived":[82],"were":[85,91,105],"formed":[86],"by":[87,107],"sonication.":[88],"These":[89],"used":[92],"fluorescent":[94],"native":[95,166],"recombinant":[97,149],"conjugates":[99],"vesicle":[101],"binding":[102,124,173,180,200,222,231,244],"assays.":[103],"Vesicles":[104],"collected":[106],"centrifugation":[108],"quantified":[113],"fluorescence":[115],"intensity":[116],"measurements.":[117],"RESULTS:":[118],"alpha-Crystallin":[119],"complexes":[120,151],"showed":[121],"remarkably":[122],"similar":[123],"profiles":[125],"for":[126,240],"all":[127],"tested,":[130],"regardless":[131],"origin,":[134],"head":[136],"group,":[137],"length":[140],"or":[141],"saturation,":[142],"inclusion":[144],"cholesterol.":[146],"bind":[152],"these":[154,196,224],"manner":[158],"that":[159,164,198,235,257],"is":[160,206,245,265],"essentially":[161],"indistinguishable":[162],"from":[163,195],"human":[167],"bovine":[169],"alpha-crystallins.":[170],"Unlike":[171],"membranes":[176,205],"containing":[177],"intrinsic":[178],"proteins,":[179],"protein-free":[184],"very":[187],"high":[188,285],"capacity":[189],"unsaturable.":[191],"CONCLUSIONS:":[192],"We":[193],"conclude":[194],"data":[197,255],"not":[207,217,266],"lipid-specific.":[208],"Furthermore,":[209],"protein":[210],"post-translational":[211],"changes,":[212,271],"such":[213,280],"as":[214,281],"phosphorylation,":[215],"do":[216],"appear":[218],"alter":[220],"vesicles.":[225],"Given":[226],"linearity":[228],"curves,":[232],"we":[233],"propose":[234],"only":[237],"limiting":[238],"factor":[239],"normal":[241],"available":[246],"surface":[247],"area":[248],"on":[249],"bilayer.":[251],"Finally,":[252],"present":[254],"suggests":[256],"increased":[258],"vivo":[260],"association":[262],"result":[268,276],"but":[272],"more":[273],"likely":[274],"non-lipid":[278],"factors":[279],"accumulation":[283],"molecular":[286],"weight":[287],"forms":[288],"alpha-crystallin.":[290]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
