{"id":"https://openalex.org/W1472835967","doi":null,"title":"The effects of modulation of the L-arginine-nitric oxide pathway on myocardial stunning following repetitive coronary occlusion in dogs.","display_name":"The effects of modulation of the L-arginine-nitric oxide pathway on myocardial stunning following repetitive coronary occlusion in dogs.","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W1472835967","mag":"1472835967","pmid":"https://pubmed.ncbi.nlm.nih.gov/8857235"},"language":"en","primary_location":{"id":"pmid:8857235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8857235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hiroshima journal of medical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hiroshima.repo.nii.ac.jp/records/2013378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037987529","display_name":"Nobuyuki Morishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"N Morishima","raw_affiliation_strings":["The First Department of Internal Medicine, Hiroshima University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, Hiroshima University School of Medicine, Japan","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037987529"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.13664575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"4","first_page":"119","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.09809999912977219,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8420000076293945},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9010000228881836},{"id":"https://openalex.org/keywords/myocardial-stunning","display_name":"myocardial stunning","score":0.9290000200271606},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.7480000257492065},{"id":"https://openalex.org/keywords/d-arginine","display_name":"D-arginine","score":0.9139999747276306},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.7179999947547913},{"id":"https://openalex.org/keywords/vasodilator-reserve","display_name":"vasodilator reserve","score":0.8289999961853027},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.8149999976158142},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.8149999976158142},{"id":"https://openalex.org/keywords/collateral-circulation","display_name":"collateral circulation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8957104086875916},{"id":"https://openalex.org/C2775992611","wikidata":"https://www.wikidata.org/wiki/Q2075261","display_name":"Myocardial stunning","level":3,"score":0.7113261222839355},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6743735074996948},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6649634838104248},{"id":"https://openalex.org/C2780393670","wikidata":"https://www.wikidata.org/wiki/Q5172192","display_name":"Coronary occlusion","level":3,"score":0.6496422290802002},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.627047061920166},{"id":"https://openalex.org/C2776157398","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary circulation","level":3,"score":0.5596675276756287},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5472497940063477},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5449846982955933},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4936014413833618},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4693540036678314},{"id":"https://openalex.org/C2776599846","wikidata":"https://www.wikidata.org/wiki/Q5145979","display_name":"Collateral circulation","level":2,"score":0.4342572093009949},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.41867950558662415},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3725430965423584},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.2807925343513489}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017682","descriptor_name":"Myocardial Stunning","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:8857235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8857235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hiroshima journal of medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02013378","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2013378","pdf_url":null,"source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"departmental bulletin paper"},{"id":"pmh:oai:ir.lib.hiroshima-u.ac.jp:00037871","doi":null,"is_oa":false,"landing_page_url":"http://ir.lib.hiroshima-u.ac.jp/00037871","pdf_url":null,"source":{"id":"https://openalex.org/S4377196292","display_name":"Hiroshima University Acedemic Information Repository (Hiroshima University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I113306721","host_organization_name":"Hiroshima University","host_organization_lineage":["https://openalex.org/I113306721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Departmental Bulletin Paper"},{"id":"pmh:oai:irdb.nii.ac.jp:01372:0006666542","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2013378","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hiroshima Journal of Medical Sciences","raw_type":"departmental bulletin paper"},{"id":"mag:1472835967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8857235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:hiroshima.repo.nii.ac.jp:02013378","doi":null,"is_oa":true,"landing_page_url":"https://hiroshima.repo.nii.ac.jp/records/2013378","pdf_url":null,"source":{"id":"https://openalex.org/S7407055456","display_name":"Hiroshima University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"departmental bulletin paper"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W35243478","https://openalex.org/W104011612","https://openalex.org/W1500094754","https://openalex.org/W1571274258","https://openalex.org/W1869462925","https://openalex.org/W1944330918","https://openalex.org/W1983304603","https://openalex.org/W2006890214","https://openalex.org/W2007454172","https://openalex.org/W2013061116","https://openalex.org/W2015977730","https://openalex.org/W2019951936","https://openalex.org/W2027223774","https://openalex.org/W2028676745","https://openalex.org/W2048635427","https://openalex.org/W2050724625","https://openalex.org/W2052658063","https://openalex.org/W2058137293","https://openalex.org/W2061897451","https://openalex.org/W2076610820","https://openalex.org/W2087592973","https://openalex.org/W2101118441","https://openalex.org/W2107429652","https://openalex.org/W2126030103","https://openalex.org/W2140542485","https://openalex.org/W2150775643","https://openalex.org/W2158878115","https://openalex.org/W2167276387","https://openalex.org/W2188202999","https://openalex.org/W2244634594","https://openalex.org/W2409856369"],"related_works":["https://openalex.org/W7009279060","https://openalex.org/W646131576","https://openalex.org/W2102749554","https://openalex.org/W2464493563","https://openalex.org/W2355700798","https://openalex.org/W2362789648","https://openalex.org/W2060308154","https://openalex.org/W1983304603","https://openalex.org/W2381132471","https://openalex.org/W2031797912"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,54,67,128],"determine":[3],"the":[4,13,37,81,115,129,140,146,189],"role":[5],"of":[6,15,36,117,142,150,159,191],"nitric":[7],"oxide":[8],"(NO)":[9],"in":[10,31,48,52,74,86,139,145,175,201,216],"myocardial":[11,203],"stunning,":[12],"effects":[14,190],"both":[16],"augmenting":[17],"and":[18,56,60,110,120,182],"inhibiting":[19],"NO":[20,198,210],"production":[21],"on":[22,40,164],"contractile":[23,132,151,165],"function,":[24],"following":[25,80,205],"repetitive":[26,206],"coronary":[27,49,70,83,111,124,207],"occlusions,":[28],"were":[29,65],"evaluated":[30],"anesthetized":[32],"dogs.":[33],"The":[34,46,148],"effect":[35,163],"experimental":[38],"protocol":[39],"endothelial":[41],"function":[42,133,152,166],"was":[43,77,126,136,153,167],"also":[44,154],"assessed.":[45],"increases":[47],"blood":[50,94,112,177],"flow":[51,178],"response":[53],"acetylcholine":[55],"nitroglycerin":[57],"at":[58],"30":[59],"60":[61],"min":[62],"after":[63,134],"reperfusion":[64,135],"similar":[66],"those":[68],"before":[69],"occlusions.":[71],"Therefore,":[72],"loss":[73],"vasodilator":[75],"reserve":[76],"not":[78,99,168,186],"observed":[79,169],"multiple":[82],"occlusions":[84,125],"used":[85],"this":[87],"study.":[88],"NG-nitro-L-arginine":[89],"methyl":[90],"ester":[91],"(L-NAME)":[92],"elevated":[93],"pressure":[95],"slightly,":[96],"but":[97],"did":[98,185],"change":[100],"left":[101,105],"ventricular":[102,106],"end-diastolic":[103],"pressure,":[104],"maximum":[107],"positive":[108],"dp/dt,":[109],"flow.":[113],"Although":[114],"degree":[116],"systolic":[118],"bulging":[119],"collateral":[121,176],"circulation":[122],"during":[123],"comparable":[127],"control":[130],"group,":[131],"significantly":[137],"worse":[138],"presence":[141],"L-NAME":[143],"than":[144],"control.":[147],"recovery":[149],"considerably":[155],"delayed":[156],"with":[157,170,180],"administration":[158],"L-arginine.":[160,192],"This":[161],"deleterious":[162],"its":[171],"enantiomer":[172],"D-arginine.":[173],"Differences":[174],"determined":[179],"microspheres":[181],"hemodynamic":[183],"variables":[184],"account":[187],"for":[188],"These":[193],"results":[194],"suggest":[195],"that":[196],"endogenous":[197],"is":[199],"important":[200],"limiting":[202],"stunning":[204],"occlusion.":[208],"However,":[209],"may":[211],"be":[212],"cytotoxic":[213],"when":[214],"present":[215],"substantial":[217],"excess.":[218]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
