{"id":"https://openalex.org/W1471495955","doi":null,"title":"Enhancement of GABAergic inhibition: a mechanism of action of benzodiazepines, phenobarbital, valproate and L-cycloserine in the cat spinal cord.","display_name":"Enhancement of GABAergic inhibition: a mechanism of action of benzodiazepines, phenobarbital, valproate and L-cycloserine in the cat spinal cord.","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W1471495955","mag":"1471495955","pmid":"https://pubmed.ncbi.nlm.nih.gov/6130936"},"language":"en","primary_location":{"id":"pmid:6130936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6130936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Electroencephalography and clinical neurophysiology. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111598451","display_name":"Peter Polc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P Polc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111598451"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.03545759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"36","issue":null,"first_page":"188","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gabaergic-inhibition","display_name":"GABAergic inhibition","score":0.9869999885559082},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.902999997138977},{"id":"https://openalex.org/keywords/phenobarbital","display_name":"phenobarbital","score":0.9980000257492065},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/l-cycloserine","display_name":"L-cycloserine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.8730000257492065},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.8690000176429749},{"id":"https://openalex.org/keywords/chloride-ionophore","display_name":"chloride ionophore","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gaba-reuptake","display_name":"GABA reuptake","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gaba-transaminase","display_name":"GABA transaminase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.7936803102493286},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7023831605911255},{"id":"https://openalex.org/C2780077838","wikidata":"https://www.wikidata.org/wiki/Q206348","display_name":"Barbiturate","level":2,"score":0.6565032005310059},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.655495822429657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6458653807640076},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.6058277487754822},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.585818886756897},{"id":"https://openalex.org/C2778900099","wikidata":"https://www.wikidata.org/wiki/Q5166679","display_name":"Convulsant","level":3,"score":0.5307300686836243},{"id":"https://openalex.org/C2777421860","wikidata":"https://www.wikidata.org/wiki/Q4637204","display_name":"GABA transaminase","level":4,"score":0.5095632076263428},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.48294705152511597},{"id":"https://openalex.org/C2781122200","wikidata":"https://www.wikidata.org/wiki/Q418508","display_name":"Cycloserine","level":3,"score":0.45329588651657104},{"id":"https://openalex.org/C2776674594","wikidata":"https://www.wikidata.org/wiki/Q306252","display_name":"GABA receptor","level":4,"score":0.45316919684410095},{"id":"https://openalex.org/C79636183","wikidata":"https://www.wikidata.org/wiki/Q5512770","display_name":"GABA receptor antagonist","level":5,"score":0.45114749670028687},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4456748962402344},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.4169232249259949},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4144551157951355},{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.3345111012458801},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3103903532028198},{"id":"https://openalex.org/C9497952","wikidata":"https://www.wikidata.org/wiki/Q419650","display_name":"Glutamate decarboxylase","level":3,"score":0.25801387429237366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.181806743144989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14777976274490356},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10501846671104431},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07828027009963989},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003523","descriptor_name":"Cycloserine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010634","descriptor_name":"Phenobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:6130936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6130936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Electroencephalography and clinical neurophysiology. Supplement","raw_type":"Journal Article"},{"id":"mag:1471495955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6130936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3024499496","https://openalex.org/W110128713","https://openalex.org/W2049312278","https://openalex.org/W2419422933","https://openalex.org/W2038873180","https://openalex.org/W1977778648","https://openalex.org/W2019196073","https://openalex.org/W2079865071","https://openalex.org/W2009713279","https://openalex.org/W1996176353"],"abstract_inverted_index":{"Unanaesthetized":[0],"spinal":[1,29],"cats":[2],"were":[3],"used":[4],"to":[5,39],"assess":[6],"the":[7,28,48,52,60,69,85],"effects":[8],"of":[9,41,62,72,87],"several":[10],"central":[11],"depressant":[12],"drugs":[13],"on":[14,47,74],"GABA-mediated":[15],"presynaptic":[16],"inhibition.":[17],"Benzodiazepines":[18],"enhance":[19],"GABAergic":[20,33],"inhibition":[21,34,61],"by":[22,35,44],"interaction":[23],"with":[24],"specific":[25],"receptors":[26],"in":[27],"cord.":[30],"Phenobarbital":[31],"facilitates":[32],"a":[36],"mechanism":[37,58],"unrelated":[38],"that":[40],"benzodiazepines,":[42],"perhaps":[43],"an":[45],"effect":[46,71],"Cl-":[49],"ionophore":[50],"within":[51],"GABA-benzodiazepine-barbiturate":[53],"receptor":[54],"complex.":[55],"A":[56],"similar":[57],"or":[59],"GABA":[63,75,80,88],"re-uptake":[64],"might":[65],"be":[66],"responsible":[67],"for":[68,90],"facilitating":[70],"valproate":[73],"transmission.":[76],"By":[77],"selectively":[78],"inhibiting":[79],"transaminase,":[81],"L-cycloserine":[82],"presumably":[83],"increases":[84],"amount":[86],"available":[89],"release.":[91]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
