{"id":"https://openalex.org/W147055158","doi":null,"title":"Characterization of Chemical and Biological Properties of Purified Porphyromonas gingivalis Free Dihydroceramides","display_name":"Characterization of Chemical and Biological Properties of Purified Porphyromonas gingivalis Free Dihydroceramides","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W147055158","mag":"147055158"},"language":"en","primary_location":{"id":"pmh:oai:opencommons.uconn.edu:sodm_masters-1160","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/sodm_masters/161","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1160&context=sodm_masters","source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SoDM Masters Theses","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1160&context=sodm_masters","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038301795","display_name":"Andrew R. Chapokas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrew Robert Chapokas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038301795"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gingival-fibroblasts","display_name":"gingival fibroblasts","score":0.7720000147819519},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.9449999928474426},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.31700000166893005},{"id":"https://openalex.org/keywords/periodontal-disease-biomarkers","display_name":"periodontal biomarkers","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.9493644833564758},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5083999037742615},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4572749435901642},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39327967166900635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3141358196735382},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.26462405920028687},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1308576464653015},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12996941804885864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08063477277755737}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:opencommons.uconn.edu:sodm_masters-1160","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/sodm_masters/161","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1160&context=sodm_masters","source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SoDM Masters Theses","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lib.uconn.edu:sodm_masters-1160","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/sodm_masters/161","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SoDM Masters Theses","raw_type":"text"},{"id":"mag:147055158","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/sodm_masters/161/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opencommons.uconn.edu:sodm_masters-1160","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/sodm_masters/161","pdf_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=1160&context=sodm_masters","source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SoDM Masters Theses","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W147055158.pdf","grobid_xml":"https://content.openalex.org/works/W147055158.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W72972769","https://openalex.org/W157203447","https://openalex.org/W1493935825","https://openalex.org/W1515994079","https://openalex.org/W1536331044","https://openalex.org/W1565546071","https://openalex.org/W1577946620","https://openalex.org/W1600112913","https://openalex.org/W1806549141","https://openalex.org/W1879694110","https://openalex.org/W1911445754","https://openalex.org/W1917716984","https://openalex.org/W1935912749","https://openalex.org/W1941759272","https://openalex.org/W1964122395","https://openalex.org/W1964788380","https://openalex.org/W1972976631","https://openalex.org/W1977811151","https://openalex.org/W1978405502","https://openalex.org/W1983602492","https://openalex.org/W1983717333","https://openalex.org/W1983806689","https://openalex.org/W1988336043","https://openalex.org/W1988343075","https://openalex.org/W1988724630","https://openalex.org/W1989881089","https://openalex.org/W1989997867","https://openalex.org/W1992040012","https://openalex.org/W1992189644","https://openalex.org/W1993652412","https://openalex.org/W1998925304","https://openalex.org/W2004954990","https://openalex.org/W2008651707","https://openalex.org/W2010040448","https://openalex.org/W2010190869","https://openalex.org/W2014259119","https://openalex.org/W2021544133","https://openalex.org/W2029189520","https://openalex.org/W2030362171","https://openalex.org/W2030639205","https://openalex.org/W2031722758","https://openalex.org/W2031893100","https://openalex.org/W2033317749","https://openalex.org/W2034555624","https://openalex.org/W2035948596","https://openalex.org/W2036007321","https://openalex.org/W2036292578","https://openalex.org/W2036856758","https://openalex.org/W2043041439","https://openalex.org/W2044756678","https://openalex.org/W2045384882","https://openalex.org/W2046234123","https://openalex.org/W2046296343","https://openalex.org/W2053386266","https://openalex.org/W2054068403","https://openalex.org/W2056403990","https://openalex.org/W2059030477","https://openalex.org/W2060250755","https://openalex.org/W2062191337","https://openalex.org/W2064174200","https://openalex.org/W2064355487","https://openalex.org/W2066684394","https://openalex.org/W2067202359","https://openalex.org/W2070120993","https://openalex.org/W2073868231","https://openalex.org/W2078524612","https://openalex.org/W2078600608","https://openalex.org/W2084193627","https://openalex.org/W2084266000","https://openalex.org/W2090350967","https://openalex.org/W2092338165","https://openalex.org/W2093123435","https://openalex.org/W2094459581","https://openalex.org/W2094995882","https://openalex.org/W2095052915","https://openalex.org/W2095574910","https://openalex.org/W2095690145","https://openalex.org/W2096728699","https://openalex.org/W2097895541","https://openalex.org/W2099231162","https://openalex.org/W2103861287","https://openalex.org/W2104261931","https://openalex.org/W2111913028","https://openalex.org/W2113361365","https://openalex.org/W2117041510","https://openalex.org/W2121451367","https://openalex.org/W2121671563","https://openalex.org/W2127156211","https://openalex.org/W2134732424","https://openalex.org/W2142737402","https://openalex.org/W2143805628","https://openalex.org/W2148409521","https://openalex.org/W2150900523","https://openalex.org/W2151241369","https://openalex.org/W2152096613","https://openalex.org/W2152311269","https://openalex.org/W2152859518","https://openalex.org/W2155643596","https://openalex.org/W2156121631","https://openalex.org/W2156326728","https://openalex.org/W2156445477","https://openalex.org/W2156806286","https://openalex.org/W2157107389","https://openalex.org/W2162200969","https://openalex.org/W2163246048","https://openalex.org/W2165191737","https://openalex.org/W2166769021","https://openalex.org/W2169497440","https://openalex.org/W2171230459","https://openalex.org/W2174056559","https://openalex.org/W2174784305","https://openalex.org/W2196045132","https://openalex.org/W2416744128"],"related_works":["https://openalex.org/W2046234123","https://openalex.org/W1495388110","https://openalex.org/W2104261931","https://openalex.org/W77993039","https://openalex.org/W2127156211","https://openalex.org/W2096682412","https://openalex.org/W2159303287","https://openalex.org/W2078600608","https://openalex.org/W2585062952","https://openalex.org/W2091565795"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,17,28,39,69,131,156,171,203,220,237,248,260,308,325,336,344,366],"the":[3,12,323,342,364],"present":[4],"investigation":[5],"is":[6],"to":[7,36,146,164,168,208,269,302,358],"purify,":[8],"characterize,":[9],"and":[10,14,43,58,80,90,103,106,118,141,193,217,226,279,289,311,318,348],"determine":[11],"chemical":[13],"biological":[15],"properties":[16],"Porphyromonas":[18],"gingivalis":[19,71,173,186,281,287],"free":[20,98],"dihydroceramides":[21,51],"(fDHC).":[22],"Effects":[23],"were":[24,63,126,144,177,188,215,230,233,313],"tested":[25],"by":[26,65,73,85,235,240],"examination":[27],"human":[29],"gingival":[30],"fibroblast":[31,166],"morphologic":[32],"changes":[33,306,369],"in":[34,48,180,294,341,363,371],"addition":[35],"their":[37],"synthesis":[38,247,259,297],"prostaglandin":[40,44,223,227],"E2":[41,224],"(PGE2)":[42],"F2\u03b1":[45,228],"(PGF2&#;)":[46],"produced":[47],"vitro.":[49],"Free":[50],"as":[52,54,114,121],"well":[53],"phosphoglycerol":[55,60],"dihydroceramide":[56,61,99],"(PGDHC),":[57],"de-esterified":[59],"(PGDHC-C15:0)":[62],"obtained":[64,84,127],"total":[66],"lipid":[67],"extraction":[68],"P.":[70,172,185,280,286],"followed":[72,239],"high":[74],"performance":[75],"liquid":[76],"chromatography":[77],"(HPLC).":[78],"Confirmation":[79],"structural":[81,107,355],"analysis":[82,108],"was":[83,101,109,161,206,250,262,274,320],"electrospray":[86],"mass":[87,243],"spectrometry":[88,244],"(ES-/+MS)":[89],"nuclear":[91],"magnetic":[92],"resonance":[93],"spectroscopy":[94],"(NMR).":[95],"A":[96],"synthetic":[97],"(A)":[100],"obtained,":[102],"its":[104],"purification":[105],"similar.":[110],"Ethanol":[111],"solvent":[112],"served":[113,120],"a":[115,122,181,345],"negative":[116],"control,":[117],"PGDHC":[119,278,288,326],"positive":[123],"control.":[124],"HGF":[125,246,258,292,309,334],"from":[128],"tissue":[129],"samples":[130,238],"two":[132],"periodontally":[133],"healthy":[134],"volunteers":[135],"during":[136],"clinical":[137],"crown":[138],"lengthening":[139],"procedures,":[140],"cell":[142],"cultures":[143],"introduced":[145],"35":[147],"mm":[148,196],"wells":[149],"previously":[150],"coated":[151],"with":[152],"ethanol":[153,303],"or":[154],"20&#;g":[155],"each":[157,209],"lipid/well.":[158],"Additional":[159],"experimentation":[160],"carried":[162,178],"out":[163,179],"investigate":[165],"response":[167],"different":[169],"concentrations":[170],"fDHC.":[174],"These":[175,328],"experiments":[176],"similar":[182,295],"manner":[183],"except":[184],"fDHC":[187,282,290],"studied":[189],"at":[190],"0.2,":[191],"2,":[192],"20":[194],"&#;g/35":[195],"well.":[197],"After":[198,211],"one":[199],"hour,":[200],"30":[201],"ng":[202,219],"interleukin-1&#;":[204],"(IL-1&#;)":[205],"added":[207],"sample.":[210],"24":[212],"hours,":[213],"supernatants":[214],"harvested":[216],"100":[218],"both":[221],"deuterated":[222],"(DPGE2)":[225],"(DPGF2&#;)":[229],"added.":[231],"Analyses":[232],"performed":[234],"derivatization":[236],"gas":[241],"chromatograph":[242],"(GC-MS).":[245],"PGF2\u03b1":[249],"unaffected":[251],"for":[252,264,277,316,322],"all":[253,265],"lipids":[254],"tested.":[255],"IL-1&#;":[256,332],"mediated":[257,333],"PGE2":[261,296,337],"greater":[263],"treatment":[266],"groups":[267],"compared":[268,301],"control;":[270],"however,":[271],"statistical":[272],"significance":[273],"only":[275,315],"achieved":[276],"(p":[283],"<":[284],".05).":[285],"treated":[291],"resulted":[293],"approximately":[298],"1.8":[299],"fold":[300],"vehicle.":[304],"Morphologic":[305],"suggestive":[307],"atrophy":[310],"apoptosis":[312],"evident":[314],"PGDHC,":[317],"this":[319],"noted":[321],"majority":[324],"experiments.":[327],"findings":[329],"suggest":[330],"that":[331],"secretion":[335],"can":[338],"occur":[339],"even":[340],"absence":[343],"phosphate":[346],"linkage":[347],"15-carbon":[349],"isobranched":[350],"methyl":[351],"ester,":[352],"but":[353],"these":[354],"elements":[356],"seem":[357],"play":[359],"an":[360],"important":[361],"role":[362],"induction":[365],"cellular":[367],"morphological":[368],"observed":[370],"phase":[372],"contrast":[373],"microscopy.":[374]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}