{"id":"https://openalex.org/W1466544342","doi":"https://doi.org/10.3233/jad-141419","title":"Characterizing Early Alzheimer's Disease and Disease Progression Using Hippocampal Volume and Arterial Spin Labeling Perfusion MRI","display_name":"Characterizing Early Alzheimer's Disease and Disease Progression Using Hippocampal Volume and Arterial Spin Labeling Perfusion MRI","publication_year":2014,"publication_date":"2014-10-27","ids":{"openalex":"https://openalex.org/W1466544342","doi":"https://doi.org/10.3233/jad-141419","mag":"1466544342","pmid":"https://pubmed.ncbi.nlm.nih.gov/25182742"},"language":"en","primary_location":{"id":"doi:10.3233/jad-141419","doi":"https://doi.org/10.3233/jad-141419","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-141419","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100443555","display_name":"Ze Wang","orcid":"https://orcid.org/0000-0002-8339-5567","observed_orcids":["https://orcid.org/0000-0002-8339-5567"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]},{"id":"https://openalex.org/I4210103863","display_name":"Affiliated Hospital of Hangzhou Normal University","ror":"https://ror.org/01bkvqx83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103863"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Ze Wang","raw_affiliation_strings":["Center for Cognition and Brain Disorders, Hangzhou Normal University, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China","Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania Treatment Research Center, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cognition and Brain Disorders, Hangzhou Normal University, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China","institution_ids":["https://openalex.org/I163151501","https://openalex.org/I4210103863"]},{"raw_affiliation_string":"Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania Treatment Research Center, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100443555"],"corresponding_institution_ids":["https://openalex.org/I163151501","https://openalex.org/I4210103863","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.9003,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.83208253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"s4","first_page":"S495","last_page":"S502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-alzheimer-s-disease","display_name":"early Alzheimer's disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C3018723549","wikidata":"https://www.wikidata.org/wiki/Q56284158","display_name":"Arterial spin labeling","level":3,"score":0.7150543332099915},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.6895869970321655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6536579728126526},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.637138843536377},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5868967771530151},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5383907556533813},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4841535687446594},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.46961647272109985},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44290003180503845},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.4303058385848999},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40556254982948303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28991445899009705},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19069018959999084},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/jad-141419","doi":"https://doi.org/10.3233/jad-141419","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-141419","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:25182742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25182742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W240388180","https://openalex.org/W1508239224","https://openalex.org/W1601400058","https://openalex.org/W1918854956","https://openalex.org/W1964982672","https://openalex.org/W1965572030","https://openalex.org/W1969403903","https://openalex.org/W1969787718","https://openalex.org/W1974111128","https://openalex.org/W1974933983","https://openalex.org/W1979613315","https://openalex.org/W1981398884","https://openalex.org/W1983482668","https://openalex.org/W1988693860","https://openalex.org/W1989854445","https://openalex.org/W1994839798","https://openalex.org/W1995204763","https://openalex.org/W2000533172","https://openalex.org/W2007543006","https://openalex.org/W2007734075","https://openalex.org/W2014886338","https://openalex.org/W2014898742","https://openalex.org/W2015629132","https://openalex.org/W2017862826","https://openalex.org/W2019261301","https://openalex.org/W2025915778","https://openalex.org/W2028822462","https://openalex.org/W2036162736","https://openalex.org/W2054732019","https://openalex.org/W2057818978","https://openalex.org/W2059729306","https://openalex.org/W2063136428","https://openalex.org/W2065056564","https://openalex.org/W2066462635","https://openalex.org/W2077466520","https://openalex.org/W2078524519","https://openalex.org/W2083060346","https://openalex.org/W2084397926","https://openalex.org/W2084787525","https://openalex.org/W2086978209","https://openalex.org/W2088301054","https://openalex.org/W2102634042","https://openalex.org/W2103105772","https://openalex.org/W2103106576","https://openalex.org/W2111240150","https://openalex.org/W2115820990","https://openalex.org/W2116641010","https://openalex.org/W2117602475","https://openalex.org/W2119848633","https://openalex.org/W2120206316","https://openalex.org/W2129006179","https://openalex.org/W2130010412","https://openalex.org/W2133703021","https://openalex.org/W2136686422","https://openalex.org/W2138960684","https://openalex.org/W2142406431","https://openalex.org/W2143731392","https://openalex.org/W2145328419","https://openalex.org/W2148046162","https://openalex.org/W2150021250","https://openalex.org/W2154758450","https://openalex.org/W2155277084","https://openalex.org/W2159122349","https://openalex.org/W2160266567","https://openalex.org/W2161167354","https://openalex.org/W2162294352","https://openalex.org/W2165278596","https://openalex.org/W2169152986","https://openalex.org/W2171250577","https://openalex.org/W2210273446"],"related_works":["https://openalex.org/W1973364640","https://openalex.org/W1918854956","https://openalex.org/W1970353750","https://openalex.org/W2032337223","https://openalex.org/W2026548816","https://openalex.org/W1569039002","https://openalex.org/W1857124936","https://openalex.org/W2354954298","https://openalex.org/W4247684960","https://openalex.org/W2001516068"],"abstract_inverted_index":{"Searching":[0],"for":[1,17,25,61,77,124],"biomarkers":[2],"sensitive":[3],"to":[4,107,136],"early":[5,90],"Alzheimer's":[6],"disease":[7,96,125],"(AD)":[8],"and":[9,36,56,114,127,141],"its":[10,30],"progression":[11,97,128],"has":[12,21,50],"been":[13,22],"a":[14,75,108],"research":[15],"priority":[16],"two":[18],"decades.":[19],"MRI":[20],"increasingly":[23],"used":[24],"this":[26],"endeavor":[27],"because":[28],"of":[29,32,53,84,110],"capability":[31],"detecting":[33],"both":[34,87],"structural":[35],"functional":[37],"brain":[38],"patterns":[39],"without":[40],"injecting":[41],"external":[42],"contrast":[43],"agent":[44],"or":[45,86],"radioactive":[46],"tracers.":[47],"Recent":[48],"work":[49],"shown":[51],"sensitivity":[52,140],"hippocampal":[54,112],"volume":[55,113],"regional":[57],"cerebral":[58,118],"blood":[59,119],"flow":[60,120],"differentiating":[62],"prodromal":[63],"AD":[64,91],"from":[65],"normal":[66],"controls":[67],"as":[68,70,93,95,121],"well":[69,94],"AD.":[71],"This":[72],"review":[73],"provides":[74],"summary":[76],"the":[78,82,103],"existing":[79],"literature":[80],"describing":[81],"applications":[83],"either":[85],"modalities":[88],"in":[89,102],"studies":[92,105,132],"assessment.":[98],"The":[99],"various":[100],"findings":[101],"reviewed":[104],"lead":[106],"conclusion":[109],"assessing":[111],"arterial":[115],"spin":[116],"labeling":[117],"potential":[122],"markers":[123],"detection,":[126],"monitoring":[129],"though":[130],"longitudinal":[131],"are":[133],"still":[134],"lacking":[135],"fully":[137],"examine":[138],"their":[139],"specificity.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
