{"id":"https://openalex.org/W14634271","doi":null,"title":"Les copolym\u00e8res \u00e0 blocs pour le transfert de g\u00e8nes dans le muscle squelettique","display_name":"Les copolym\u00e8res \u00e0 blocs pour le transfert de g\u00e8nes dans le muscle squelettique","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W14634271","mag":"14634271"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/788910","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/788910","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052309452","display_name":"Peggy Richard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peggy Richard-Fiardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052309452"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/block-copolymers","display_name":"block copolymers","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dystrophin-expression","display_name":"dystrophin expression","score":0.9190000295639038},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6300327181816101},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41358911991119385},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.38649702072143555},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.336597204208374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22272077202796936}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/788910","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/788910","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:14634271","doi":null,"is_oa":false,"landing_page_url":"http://archive.bu.univ-nantes.fr/pollux/fichiers/download/b2fb31d4-0fb0-464c-9dd7-fa6851471492","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":396,"referenced_works":["https://openalex.org/W5487435","https://openalex.org/W33106619","https://openalex.org/W37310352","https://openalex.org/W49568564","https://openalex.org/W78431147","https://openalex.org/W79619366","https://openalex.org/W87943494","https://openalex.org/W93858874","https://openalex.org/W140162132","https://openalex.org/W141976550","https://openalex.org/W153969468","https://openalex.org/W167290666","https://openalex.org/W328642312","https://openalex.org/W388311862","https://openalex.org/W1490324405","https://openalex.org/W1490628679","https://openalex.org/W1502243809","https://openalex.org/W1515676539","https://openalex.org/W1518166843","https://openalex.org/W1530368384","https://openalex.org/W1541323919","https://openalex.org/W1550111394","https://openalex.org/W1556818178","https://openalex.org/W1573565266","https://openalex.org/W1579604458","https://openalex.org/W1582618874","https://openalex.org/W1591290084","https://openalex.org/W1593294300","https://openalex.org/W1641001208","https://openalex.org/W1769569140","https://openalex.org/W1782775259","https://openalex.org/W1783580437","https://openalex.org/W1903105706","https://openalex.org/W1942221917","https://openalex.org/W1963143659","https://openalex.org/W1963500271","https://openalex.org/W1963637896","https://openalex.org/W1964504795","https://openalex.org/W1964692434","https://openalex.org/W1964696510","https://openalex.org/W1965879742","https://openalex.org/W1965895243","https://openalex.org/W1967142154","https://openalex.org/W1967344018","https://openalex.org/W1967391351","https://openalex.org/W1968152282","https://openalex.org/W1968776983","https://openalex.org/W1968869845","https://openalex.org/W1969120034","https://openalex.org/W1969918693","https://openalex.org/W1969984556","https://openalex.org/W1970204601","https://openalex.org/W1970561503","https://openalex.org/W1970708694","https://openalex.org/W1970829763","https://openalex.org/W1970987711","https://openalex.org/W1971047566","https://openalex.org/W1971189597","https://openalex.org/W1971832103","https://openalex.org/W1972575220","https://openalex.org/W1972852573","https://openalex.org/W1972892361","https://openalex.org/W1974795397","https://openalex.org/W1976302635","https://openalex.org/W1976847858","https://openalex.org/W1976998457","https://openalex.org/W1977997274","https://openalex.org/W1978507399","https://openalex.org/W1979273971","https://openalex.org/W1980142871","https://openalex.org/W1982792515","https://openalex.org/W1982795567","https://openalex.org/W1982976655","https://openalex.org/W1983271605","https://openalex.org/W1983877930","https://openalex.org/W1985396526","https://openalex.org/W1985631236","https://openalex.org/W1986088843","https://openalex.org/W1986199554","https://openalex.org/W1986390617","https://openalex.org/W1986964001","https://openalex.org/W1987025101","https://openalex.org/W1987998725","https://openalex.org/W1988556506","https://openalex.org/W1988607142","https://openalex.org/W1988970581","https://openalex.org/W1989205257","https://openalex.org/W1989297603","https://openalex.org/W1989424614","https://openalex.org/W1989429684","https://openalex.org/W1989584016","https://openalex.org/W1991248271","https://openalex.org/W1991945869","https://openalex.org/W1992251016","https://openalex.org/W1992441848","https://openalex.org/W1992462910","https://openalex.org/W1993223472","https://openalex.org/W1993711956","https://openalex.org/W1994696324","https://openalex.org/W1996755176","https://openalex.org/W1996860050","https://openalex.org/W1997314189","https://openalex.org/W1997408589","https://openalex.org/W1998323764","https://openalex.org/W1999503198","https://openalex.org/W1999707071","https://openalex.org/W1999939170","https://openalex.org/W2000577212","https://openalex.org/W2001080768","https://openalex.org/W2005275397","https://openalex.org/W2005539691","https://openalex.org/W2005750795","https://openalex.org/W2006056006","https://openalex.org/W2006434443","https://openalex.org/W2007095985","https://openalex.org/W2008613238","https://openalex.org/W2008759079","https://openalex.org/W2009593715","https://openalex.org/W2011025411","https://openalex.org/W2011229774","https://openalex.org/W2011501264","https://openalex.org/W2012665920","https://openalex.org/W2013905916","https://openalex.org/W2014495927","https://openalex.org/W2014976983","https://openalex.org/W2015224754","https://openalex.org/W2015789556","https://openalex.org/W2016110802","https://openalex.org/W2017403784","https://openalex.org/W2017449118","https://openalex.org/W2017646000","https://openalex.org/W2017902734","https://openalex.org/W2018160325","https://openalex.org/W2018744718","https://openalex.org/W2018772637","https://openalex.org/W2018823858","https://openalex.org/W2020324580","https://openalex.org/W2021208088","https://openalex.org/W2022434236","https://openalex.org/W2022701397","https://openalex.org/W2022704908","https://openalex.org/W2022736892","https://openalex.org/W2024384131","https://openalex.org/W2024722883","https://openalex.org/W2026580009","https://openalex.org/W2027210778","https://openalex.org/W2027982276","https://openalex.org/W2031219196","https://openalex.org/W2031776039","https://openalex.org/W2031857161","https://openalex.org/W2031892511","https://openalex.org/W2031948766","https://openalex.org/W2036212880","https://openalex.org/W2036704181","https://openalex.org/W2037332421","https://openalex.org/W2037574072","https://openalex.org/W2037703905","https://openalex.org/W2038009703","https://openalex.org/W2038198568","https://openalex.org/W2038491737","https://openalex.org/W2040252492","https://openalex.org/W2040507881","https://openalex.org/W2041454388","https://openalex.org/W2042271211","https://openalex.org/W2042419078","https://openalex.org/W2043297755","https://openalex.org/W2043317882","https://openalex.org/W2043692200","https://openalex.org/W2044001092","https://openalex.org/W2044949956","https://openalex.org/W2044961049","https://openalex.org/W2045209051","https://openalex.org/W2045787527","https://openalex.org/W2045963280","https://openalex.org/W2046740401","https://openalex.org/W2047015778","https://openalex.org/W2047256102","https://openalex.org/W2047783452","https://openalex.org/W2048162805","https://openalex.org/W2048457252","https://openalex.org/W2048715277","https://openalex.org/W2049761547","https://openalex.org/W2050138695","https://openalex.org/W2050216221","https://openalex.org/W2050687757","https://openalex.org/W2051189314","https://openalex.org/W2051192335","https://openalex.org/W2051259574","https://openalex.org/W2051729665","https://openalex.org/W2051942524","https://openalex.org/W2052168867","https://openalex.org/W2052194344","https://openalex.org/W2053628474","https://openalex.org/W2054523950","https://openalex.org/W2054577719","https://openalex.org/W2054677438","https://openalex.org/W2055720597","https://openalex.org/W2055818315","https://openalex.org/W2056291521","https://openalex.org/W2056322471","https://openalex.org/W2057548071","https://openalex.org/W2058527659","https://openalex.org/W2058819269","https://openalex.org/W2058931066","https://openalex.org/W2059906182","https://openalex.org/W2059978662","https://openalex.org/W2060628728","https://openalex.org/W2061353791","https://openalex.org/W2062513117","https://openalex.org/W2063250903","https://openalex.org/W2063291958","https://openalex.org/W2063534023","https://openalex.org/W2063635957","https://openalex.org/W2063711724","https://openalex.org/W2064188038","https://openalex.org/W2064330002","https://openalex.org/W2065009763","https://openalex.org/W2065257588","https://openalex.org/W2065392104","https://openalex.org/W2065519064","https://openalex.org/W2066723998","https://openalex.org/W2066950610","https://openalex.org/W2067653648","https://openalex.org/W2070206132","https://openalex.org/W2070289031","https://openalex.org/W2070683761","https://openalex.org/W2071582261","https://openalex.org/W2071679836","https://openalex.org/W2071876396","https://openalex.org/W2072847969","https://openalex.org/W2073622625","https://openalex.org/W2073746782","https://openalex.org/W2076237922","https://openalex.org/W2076310543","https://openalex.org/W2076462595","https://openalex.org/W2077477657","https://openalex.org/W2077508813","https://openalex.org/W2078325631","https://openalex.org/W2078966715","https://openalex.org/W2080303475","https://openalex.org/W2081053835","https://openalex.org/W2081178594","https://openalex.org/W2081574969","https://openalex.org/W2081761358","https://openalex.org/W2081834777","https://openalex.org/W2083029419","https://openalex.org/W2083225096","https://openalex.org/W2083700023","https://openalex.org/W2084480543","https://openalex.org/W2084689242","https://openalex.org/W2084742882","https://openalex.org/W2084936584","https://openalex.org/W2085602292","https://openalex.org/W2085989006","https://openalex.org/W2086358894","https://openalex.org/W2086437884","https://openalex.org/W2086656837","https://openalex.org/W2086703797","https://openalex.org/W2087924428","https://openalex.org/W2088151973","https://openalex.org/W2088191089","https://openalex.org/W2088540455","https://openalex.org/W2089229823","https://openalex.org/W2089688033","https://openalex.org/W2090087191","https://openalex.org/W2090269652","https://openalex.org/W2090429649","https://openalex.org/W2090849645","https://openalex.org/W2091081049","https://openalex.org/W2091163726","https://openalex.org/W2091177028","https://openalex.org/W2091781047","https://openalex.org/W2092319933","https://openalex.org/W2092447252","https://openalex.org/W2092539773","https://openalex.org/W2092738808","https://openalex.org/W2093377166","https://openalex.org/W2093415150","https://openalex.org/W2093750771","https://openalex.org/W2094208778","https://openalex.org/W2094472747","https://openalex.org/W2095042618","https://openalex.org/W2095342727","https://openalex.org/W2096908318","https://openalex.org/W2097465717","https://openalex.org/W2097546386","https://openalex.org/W2098016509","https://openalex.org/W2098051622","https://openalex.org/W2098180852","https://openalex.org/W2100545183","https://openalex.org/W2100688795","https://openalex.org/W2103980854","https://openalex.org/W2104941143","https://openalex.org/W2105969597","https://openalex.org/W2106220546","https://openalex.org/W2106266655","https://openalex.org/W2106490838","https://openalex.org/W2109081740","https://openalex.org/W2109247464","https://openalex.org/W2110154453","https://openalex.org/W2110245158","https://openalex.org/W2110579325","https://openalex.org/W2111279074","https://openalex.org/W2111444354","https://openalex.org/W2112800574","https://openalex.org/W2113267766","https://openalex.org/W2113978517","https://openalex.org/W2114587721","https://openalex.org/W2114700952","https://openalex.org/W2115039021","https://openalex.org/W2116041955","https://openalex.org/W2117580867","https://openalex.org/W2117959708","https://openalex.org/W2118252229","https://openalex.org/W2121294788","https://openalex.org/W2121830723","https://openalex.org/W2122018739","https://openalex.org/W2122020468","https://openalex.org/W2122245738","https://openalex.org/W2122340353","https://openalex.org/W2124337564","https://openalex.org/W2124791711","https://openalex.org/W2126420743","https://openalex.org/W2126439225","https://openalex.org/W2126792732","https://openalex.org/W2128439024","https://openalex.org/W2128737280","https://openalex.org/W2130513320","https://openalex.org/W2131133401","https://openalex.org/W2132793803","https://openalex.org/W2134233815","https://openalex.org/W2136218848","https://openalex.org/W2136482187","https://openalex.org/W2138978451","https://openalex.org/W2139105998","https://openalex.org/W2139763819","https://openalex.org/W2141783200","https://openalex.org/W2142334980","https://openalex.org/W2142488497","https://openalex.org/W2143223372","https://openalex.org/W2143516374","https://openalex.org/W2144066540","https://openalex.org/W2144869284","https://openalex.org/W2144871657","https://openalex.org/W2147915442","https://openalex.org/W2148884927","https://openalex.org/W2150329966","https://openalex.org/W2150712887","https://openalex.org/W2151521047","https://openalex.org/W2152738960","https://openalex.org/W2156052570","https://openalex.org/W2158494985","https://openalex.org/W2159397356","https://openalex.org/W2160400422","https://openalex.org/W2160899676","https://openalex.org/W2162154830","https://openalex.org/W2162407583","https://openalex.org/W2162885883","https://openalex.org/W2169243344","https://openalex.org/W2176002001","https://openalex.org/W2176385927","https://openalex.org/W2176396747","https://openalex.org/W2176567427","https://openalex.org/W2177596823","https://openalex.org/W2233324270","https://openalex.org/W2301740330","https://openalex.org/W2314253289","https://openalex.org/W2316735326","https://openalex.org/W2317269439","https://openalex.org/W2322189010","https://openalex.org/W2322260473","https://openalex.org/W2322780762","https://openalex.org/W2324239190","https://openalex.org/W2325463716","https://openalex.org/W2326611690","https://openalex.org/W2326841671","https://openalex.org/W2328625464","https://openalex.org/W2329010584","https://openalex.org/W2329280495","https://openalex.org/W2329662932","https://openalex.org/W2330489414","https://openalex.org/W2330930141","https://openalex.org/W2345486723","https://openalex.org/W2393222396","https://openalex.org/W2397578637","https://openalex.org/W2402697100","https://openalex.org/W2403579664","https://openalex.org/W2404930750","https://openalex.org/W2409119244","https://openalex.org/W2411047874","https://openalex.org/W2411053722","https://openalex.org/W2412594790","https://openalex.org/W2414145684","https://openalex.org/W2415625851","https://openalex.org/W2418824532","https://openalex.org/W2425074242"],"related_works":["https://openalex.org/W7008221852","https://openalex.org/W4231090528","https://openalex.org/W7143351630","https://openalex.org/W2135609389","https://openalex.org/W7025212760","https://openalex.org/W6981040710","https://openalex.org/W7039762969","https://openalex.org/W76249363","https://openalex.org/W2068761404","https://openalex.org/W643305838"],"abstract_inverted_index":{"Le":[0,78,92],"transfert":[1,33,93,139],"de":[2,10,20,34,44,51,64,88,96,100,108,113,127,132,140,173],"g\u00e8nes":[3,35],"dans":[4,36],"le":[5,18,32,138,151,171],"muscle":[6,79],"squelettique":[7,80],"\u00e0":[8,41,98,102,166],"l'aide":[9,99],"vecteurs":[11,28,54],"synth\u00e9tiques":[12,29],"repr\u00e9sente":[13],"une":[14],"strat\u00e9gie":[15],"prometteuse":[16],"pour":[17,31,61],"traitement":[19],"maladies":[21],"g\u00e9n\u00e9tiques":[22],"h\u00e9r\u00e9ditaires":[23],"ou":[24],"acquises.":[25],"Parmi":[26],"les":[27,39],"utilis\u00e9s":[30],"cet":[37],"organe,":[38],"copolym\u00e8res":[40,101,165],"blocs":[42,103],"pr\u00e9sentent":[43],"nombreux":[45],"avantages":[46],"en":[47,115,145],"terme":[48],"d'efficacit\u00e9":[49],"et":[50,67],"toxicit\u00e9.":[52],"Ces":[53],"se":[55],"sont":[56],"r\u00e9v\u00e9l\u00e9s":[57],"\u00eatre":[58,83],"tr\u00e8s":[59],"efficaces":[60],"permettre":[62],"l'expression":[63,129],"la":[65,68,75,106,124,143],"dystrophine":[66],"restauration":[69],"du":[70,94,130,158],"complexe":[71],"dystroglycoprot\u00e9ique":[72],"membranaire":[73],"chez":[74,110],"souris":[76,114],"myopathe.":[77],"peut":[81],"\u00e9galement":[82],"utilis\u00e9":[84],"comme":[85],"organe":[86],"s\u00e9cr\u00e9teur":[87],"prot\u00e9ines":[89],"th\u00e9rapeutiques":[90],"syst\u00e9miques.":[91],"g\u00e8ne":[95,131,141,159],"l'\u00e9rythropo\u00ef\u00e9tine":[97,133,161],"a":[104],"permis":[105],"correction":[107],"l'an\u00e9mie":[109],"un":[111],"mod\u00e8le":[112],"insuffisance":[116],"r\u00e9nale":[117],"chronique.":[118],"L'utilisation":[119],"d'un":[120],"promoteur":[121],"inductible":[122],"par":[123],"doxycycline":[125],"permet":[126,168],"r\u00e9guler":[128],"jusqu'\u00e0":[134],"4":[135],"mois":[136],"apr\u00e8s":[137],"avant":[142],"mise":[144],"place":[146],"d'une":[147],"r\u00e9action":[148],"immunitaire":[149],"contre":[150],"transactivateur":[152],"chim\u00e9rique.":[153],"La":[154],"r\u00e9p\u00e9tition":[155],"d'injections":[156],"intramusculaires":[157],"codant":[160],"formul\u00e9":[162],"avec":[163],"des":[164],"blocs,":[167],"d'adapter":[169],"durablement":[170],"niveau":[172],"s\u00e9cr\u00e9tion":[174],"d'\u00e9rythropo\u00ef\u00e9tine":[175]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}