{"id":"https://openalex.org/W146333002","doi":null,"title":"An Open Trial of Sustained Release Bupropion for Attention-Deficit/Hyperactivity Disorder in Adults with ADHD plus Substance Use Disorders.","display_name":"An Open Trial of Sustained Release Bupropion for Attention-Deficit/Hyperactivity Disorder in Adults with ADHD plus Substance Use Disorders.","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W146333002","mag":"146333002","pmid":"https://pubmed.ncbi.nlm.nih.gov/22500195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3322541"},"language":"en","primary_location":{"id":"pmid:22500195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22500195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ADHD & related disorders","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3322541","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000660066","display_name":"Timothy E. Wilens","orcid":"https://orcid.org/0000-0002-5749-8503","observed_orcids":["https://orcid.org/0000-0002-5749-8503"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy E Wilens","raw_affiliation_strings":["Pediatric Psychopharmacology Clinic, Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Psychopharmacology Clinic, Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028349876","display_name":"Jefferson B. Prince","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jefferson B Prince","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002366156","display_name":"James G. Waxmonsky","orcid":"https://orcid.org/0000-0002-5563-3417","observed_orcids":["https://orcid.org/0000-0002-5563-3417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Waxmonsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113555812","display_name":"Robert Doyle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Doyle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091444284","display_name":"Thomas Spencer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Spencer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066314177","display_name":"MaryKate Martelon","orcid":"https://orcid.org/0000-0003-0719-3426","observed_orcids":["https://orcid.org/0000-0003-0719-3426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marykate Martelon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011321892","display_name":"M F Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maggie Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9593,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.73710275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"3","first_page":"25","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bupropion","display_name":"bupropion","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sustained-release-bupropion","display_name":"bupropion sustained release","score":0.9789999723434448},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9760000109672546},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.8420000076293945},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.7440000176429749},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.6890000104904175},{"id":"https://openalex.org/keywords/adhd-symptom-severity","display_name":"ADHD symptom severity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/substance-use","display_name":"substance use","score":0.4740000069141388},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.7360000014305115},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C2779908668","wikidata":"https://www.wikidata.org/wiki/Q834280","display_name":"Bupropion","level":3,"score":0.9088888764381409},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7543936967849731},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.672654926776886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5661801695823669},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5051589608192444},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.448326975107193},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.420958936214447},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4103323221206665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2988549470901489},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.10628125071525574},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:22500195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22500195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ADHD & related disorders","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3322541","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3322541","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J ADHD Relat Disord","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.669.968","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.669.968","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322541/pdf/nihms322989.pdf","raw_type":"text"},{"id":"mag:146333002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22500195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3322541","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3322541","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J ADHD Relat Disord","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3542233675","display_name":"Etiologies of Stimulant Misuse in College Students","funder_award_id":"K24DA016264","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W74971179","https://openalex.org/W564492501","https://openalex.org/W629283852","https://openalex.org/W1680855902","https://openalex.org/W1682399119","https://openalex.org/W1684863429","https://openalex.org/W1966490087","https://openalex.org/W1966811160","https://openalex.org/W1970664643","https://openalex.org/W1971305678","https://openalex.org/W1981364866","https://openalex.org/W1991926863","https://openalex.org/W1994589145","https://openalex.org/W1995973822","https://openalex.org/W1998889977","https://openalex.org/W2002857128","https://openalex.org/W2005075493","https://openalex.org/W2008181018","https://openalex.org/W2012404451","https://openalex.org/W2025861053","https://openalex.org/W2028075521","https://openalex.org/W2031077099","https://openalex.org/W2055941668","https://openalex.org/W2061126019","https://openalex.org/W2067495470","https://openalex.org/W2072136747","https://openalex.org/W2072775036","https://openalex.org/W2072946923","https://openalex.org/W2080586308","https://openalex.org/W2085389018","https://openalex.org/W2091029144","https://openalex.org/W2093587140","https://openalex.org/W2097467510","https://openalex.org/W2108483316","https://openalex.org/W2111394394","https://openalex.org/W2114613490","https://openalex.org/W2116058617","https://openalex.org/W2122518346","https://openalex.org/W2123910896","https://openalex.org/W2125393606","https://openalex.org/W2143384791","https://openalex.org/W2145616005","https://openalex.org/W2146314019","https://openalex.org/W2153544652","https://openalex.org/W2159881136","https://openalex.org/W2160070901","https://openalex.org/W2169861403","https://openalex.org/W2317321545","https://openalex.org/W2735928575"],"related_works":["https://openalex.org/W2028075521","https://openalex.org/W2116058617","https://openalex.org/W2005075493","https://openalex.org/W2026606034","https://openalex.org/W2151045040","https://openalex.org/W1994589145","https://openalex.org/W2150259018","https://openalex.org/W1573706348","https://openalex.org/W1683033811","https://openalex.org/W1682399119"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,100,113,123,144,153],"effectiveness":[4],"and":[5,15,44,53,75,122,151,174],"tolerability":[6],"of":[7,29,60,128,146,156],"bupropion":[8,32],"in":[9,33,112,170,185],"adults":[10,34,171],"with":[11,41,84,94,96,172,177,181],"Attention-Deficit/Hyperactivity":[12],"Disorder":[13],"(ADHD)":[14],"comorbid":[16],"active":[17],"Substance":[18],"Use":[19],"Disorders":[20],"(SUD).":[21],"METHODS:":[22],"This":[23],"was":[24,47],"a":[25,57],"six-week":[26],"open":[27,166],"trial":[28,167],"sustained-release":[30],"(SR)":[31],"aged":[35],"18":[36],"to":[37,56,82,117],"55":[38],"years":[39],"diagnosed":[40],"both":[42],"ADHD":[43,114,129,173],"SUD.":[45,189],"Bupropion-SR":[46],"initiated":[48],"at":[49],"100":[50],"mg":[51,62],"SR":[52,63],"increased":[54],"weekly":[55],"target":[58],"dose":[59],"200":[61],"twice":[64],"daily.":[65],"Subjects":[66],"were":[67,80,92,108,139],"assessed":[68],"on":[69,143,152],"multiple":[70],"outcomes":[71],"including":[72],"ADHD,":[73,186],"SUD,":[74,175],"adverse":[76],"effects.":[77],"All":[78],"analyses":[79],"intent":[81],"treat,":[83],"last":[85],"observation":[86],"carried":[87],"forward.":[88],"RESULTS:":[89],"Thirty-two":[90],"subjects":[91,98],"treated":[93],"bupropion,":[95],"nineteen":[97],"completing":[99],"entire":[101],"protocol":[102],"(59%).":[103],"At":[104],"end":[105],"point":[106],"there":[107,138],"clinically":[109,140,182],"significant":[110,183],"reductions":[111,184],"RS":[115],"(34.1\u00b18.2":[116],"19.4\u00b111.4,":[118],"-43%,":[119],"t=6.49,":[120],"p<0.0001)":[121],"Clinical":[124],"Global":[125],"Impression":[126],"(CGI)":[127],"severity":[130,158],"(baseline=5.0,":[131],"endpoint=3.8,":[132],"-24%,":[133],"t=6.16,":[134],"p<0.0001).":[135,161],"In":[136],"contrast,":[137],"negligible":[141],"effects":[142],"self-report":[145],"substance":[147],"use":[148],"(p's":[149],">0.05)":[150],"overall":[154],"CGI":[155],"SUD":[157],"(-23%,":[159],"t=4.95,":[160],"CONCLUSIONS:":[162],"Results":[163],"from":[164],"this":[165],"suggest":[168],"that":[169],"treatment":[176],"bupropion-SR":[178],"is":[179],"associated":[180],"but":[187],"not":[188]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
