{"id":"https://openalex.org/W146246787","doi":null,"title":"Enhanced delivery of etoposide to Dalton's lymphoma in mice through polysorbate 20 micelles.","display_name":"Enhanced delivery of etoposide to Dalton's lymphoma in mice through polysorbate 20 micelles.","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W146246787","mag":"146246787","pmid":"https://pubmed.ncbi.nlm.nih.gov/16613722"},"language":"en","primary_location":{"id":"pmid:16613722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16613722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmaceutica (Zagreb, Croatia)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hrcak.srce.hr/4549","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059351608","display_name":"Lakkireddy Harivardhan Reddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lakkireddy Harivardhan Reddy","raw_affiliation_strings":["Drug Delivery Research Laboratory, Center of Relevance and Excellence in NDDS, Pharmacy Department, G.H. Patel Building, Donor's Plaza, Fatehgunj Baroda-390002, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Delivery Research Laboratory, Center of Relevance and Excellence in NDDS, Pharmacy Department, G.H. Patel Building, Donor's Plaza, Fatehgunj Baroda-390002, Gujarat, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700219","display_name":"Rakesh Kumar Sharma","orcid":"https://orcid.org/0000-0003-0131-2228","observed_orcids":["https://orcid.org/0000-0003-0131-2228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rakesh Kumar Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113717056","display_name":"Rayasa Ramachandra Murthy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rayasa Ramachandra Murthy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4742,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.59257693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"56","issue":"2","first_page":"143","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.996999979019165},{"id":"https://openalex.org/keywords/tween-20","display_name":"Tween 20","score":0.9430000185966492},{"id":"https://openalex.org/keywords/micelles","display_name":"micelles","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dalton-s-lymphoma","display_name":"Dalton's lymphoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6539999842643738},{"id":"https://openalex.org/keywords/99mtc-radiolabeling","display_name":"99mTc radiolabeling","score":0.878000020980835},{"id":"https://openalex.org/keywords/tumor-uptake","display_name":"tumor uptake","score":0.6269999742507935},{"id":"https://openalex.org/keywords/tumor-retention","display_name":"tumor retention","score":0.800000011920929},{"id":"https://openalex.org/keywords/critical-micelle-concentration","display_name":"critical micelle concentration","score":0.7540000081062317},{"id":"https://openalex.org/keywords/transchelation","display_name":"transchelation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/serum-stability","display_name":"serum stability","score":0.8679999709129333},{"id":"https://openalex.org/keywords/brain-tumor-imaging","display_name":"brain tumor imaging","score":0.47099998593330383},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8153494000434875},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.6927130222320557},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.6283944845199585},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.5717978477478027},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5105791687965393},{"id":"https://openalex.org/C64237528","wikidata":"https://www.wikidata.org/wiki/Q607000","display_name":"Critical micelle concentration","level":4,"score":0.4413905739784241},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.4199599027633667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24509596824645996},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24410969018936157},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09259572625160217},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.08237630128860474},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07920476794242859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07602962851524353},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011136","descriptor_name":"Polysorbates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16613722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16613722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmaceutica (Zagreb, Croatia)","raw_type":"Journal Article"},{"id":"pmh:oai:hrcak.srce.hr:4549","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/4549","pdf_url":null,"source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharmaceutica","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:hrcak.srce.hr:4549","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/4549","pdf_url":null,"source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharmaceutica","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1480562807","https://openalex.org/W1482904772","https://openalex.org/W1722373994","https://openalex.org/W1965021784","https://openalex.org/W1986269836","https://openalex.org/W1996231251","https://openalex.org/W2000274534","https://openalex.org/W2004276356","https://openalex.org/W2007565792","https://openalex.org/W2013683557","https://openalex.org/W2018659527","https://openalex.org/W2029822118","https://openalex.org/W2032959148","https://openalex.org/W2042588181","https://openalex.org/W2056272101","https://openalex.org/W2059405105","https://openalex.org/W2070838947","https://openalex.org/W2071896997","https://openalex.org/W2072054720","https://openalex.org/W2076750727","https://openalex.org/W2081054963","https://openalex.org/W2089618778","https://openalex.org/W2120377744","https://openalex.org/W2121811587","https://openalex.org/W2158448399","https://openalex.org/W2159185370","https://openalex.org/W2160271899","https://openalex.org/W2273684068","https://openalex.org/W2400636051","https://openalex.org/W2473884936"],"related_works":["https://openalex.org/W2624168835","https://openalex.org/W2016021253","https://openalex.org/W2060483113","https://openalex.org/W2029961416","https://openalex.org/W2516031866","https://openalex.org/W2068956748","https://openalex.org/W1979298161","https://openalex.org/W2073219576","https://openalex.org/W2060044923","https://openalex.org/W1190652070"],"abstract_inverted_index":{"The":[0,21,96,117],"study":[1],"evaluates":[2],"the":[3,28,52,81,182,188],"possibility":[4],"of":[5,8,48,54,107,131,185,190],"enhancing":[6],"uptake":[7,138,157],"etoposide":[9,70],"(topoisomerase":[10],"II":[11],"inhibitor)":[12],"by":[13,26,40,80,124,161],"tumor":[14,137,154],"when":[15],"delivered":[16],"through":[17],"polysorbate":[18,72],"20":[19,56,73],"micelles.":[20],"micelle":[22],"formation":[23],"was":[24,158],"ascertained":[25],"determining":[27],"critical":[29],"micellar":[30],"concentration":[31],"(CMC)":[32],"with":[33,78],"a":[34],"du":[35],"Nouy":[36],"ring":[37],"tensiometer":[38],"and":[39,69,99,109,152],"size":[41],"measurement":[42],"using":[43,84],"dynamic":[44],"light":[45],"scattering.":[46],"Addition":[47],"5%":[49],"ethanol":[50],"decreased":[51],"CMC":[53],"Polysorbate":[55],"(from":[57],"5.0":[58],"x":[59,63],"10(-5)":[60,64],"to":[61,91,143,179],"4.54":[62],"mol":[65],"L(-1)).":[66],"Etoposide":[67],"(ET)":[68],"loaded":[71],"micelles":[74],"(EPM)":[75],"were":[76,89],"radiolabeled":[77],"99mTc":[79],"reduction":[82],"method":[83],"stannous":[85],"chloride.":[86],"Labeling":[87],"parameters":[88],"optimized":[90],"obtain":[92],"high":[93,168],"labeling":[94],"efficiency.":[95],"diethylenetriaminepentaacetic":[97],"acid":[98],"cysteine":[100],"challenge":[101],"tests":[102],"showed":[103],"very":[104],"low":[105],"transchelation":[106],"99mTc-ET":[108],"99mTc-EPM":[110],"complexes":[111,118],"indicating":[112],"their":[113],"in":[114,134,187],"vitro":[115],"stability.":[116],"also":[119,159],"exhibited":[120,166],"serum":[121],"stability":[122],"assessed":[123],"ascending":[125],"thin":[126],"layer":[127],"chromatography.":[128],"Subcutaneous":[129],"injection":[130],"EPM":[132,165,186],"resulted":[133],"significantly":[135],"higher":[136],"(":[139,171],"100":[140],"folds":[141],"compared":[142,178],"ET":[144],"6":[145],"h":[146,175],"post":[147,176],"injection)":[148,177],"(p":[149],"<":[150],"0.001)":[151],"prolonged":[153],"retention.":[155],"Tumor":[156],"confirmed":[160],"gamma":[162],"imaging":[163],"studies.":[164],"relatively":[167],"brain":[169,191],"concentrations":[170],"7":[172],"fold":[173],"24":[174],"ET,":[180],"suggesting":[181],"potential":[183],"use":[184],"treatment":[189],"malignancies.":[192]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}