{"id":"https://openalex.org/W146013375","doi":"https://doi.org/10.1007/978-1-4612-0411-4_15","title":"The HIV tat Gene Induces Epidermal Hyperplasia in vivo and Transforms Keratinocytes in vitro","display_name":"The HIV tat Gene Induces Epidermal Hyperplasia in vivo and Transforms Keratinocytes in vitro","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W146013375","doi":"https://doi.org/10.1007/978-1-4612-0411-4_15","mag":"146013375"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4612-0411-4_15","doi":"https://doi.org/10.1007/978-1-4612-0411-4_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-0411-4_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplastic Transformation in Human Cell Culture","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2484655577","display_name":"Neoplastic Transformation in Human Cell Culture"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019378554","display_name":"Jonathan A. Rhim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Rhim","raw_affiliation_strings":["Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060729846","display_name":"Jonathan C. Vogel","orcid":"https://orcid.org/0000-0002-7102-0231","observed_orcids":["https://orcid.org/0000-0002-7102-0231"]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Vogel","raw_affiliation_strings":["Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chang-Min Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang-Min Kim","raw_affiliation_strings":["Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gilbert Jay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilbert Jay","raw_affiliation_strings":["Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104110495","display_name":"Johng Sik Rhim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johng S. Rhim","raw_affiliation_strings":["Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA","Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA","institution_ids":["https://openalex.org/I1343864894"]},{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19285714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"143","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.32030001282691956,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.32030001282691956,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.16349999606609344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.15780000388622284,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-hyperplasia","display_name":"epidermal hyperplasia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/keratinocyte-transformation","display_name":"keratinocyte transformation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/seborrheic-dermatitis","display_name":"seborrheic dermatitis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.6390777230262756},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6189028024673462},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5655614137649536},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.5181875824928284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47065773606300354},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4641716480255127},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4576728343963623},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45305365324020386},{"id":"https://openalex.org/C2779236070","wikidata":"https://www.wikidata.org/wiki/Q725345","display_name":"Kaposi's sarcoma","level":4,"score":0.4298175573348999},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40817564725875854},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.39522993564605713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31217730045318604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25364214181900024},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.19349405169487},{"id":"https://openalex.org/C3018958071","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Human herpesvirus","level":3,"score":0.08996492624282837},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4612-0411-4_15","doi":"https://doi.org/10.1007/978-1-4612-0411-4_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-0411-4_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplastic Transformation in Human Cell Culture","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W84889660","https://openalex.org/W1812794742","https://openalex.org/W1967295852","https://openalex.org/W1973584400","https://openalex.org/W1975104035","https://openalex.org/W1979861012","https://openalex.org/W1989001888","https://openalex.org/W1990678611","https://openalex.org/W1995153925","https://openalex.org/W2009510376","https://openalex.org/W2017607160","https://openalex.org/W2021081081","https://openalex.org/W2033217413","https://openalex.org/W2041798017","https://openalex.org/W2051836311","https://openalex.org/W2065418754","https://openalex.org/W2071972670","https://openalex.org/W2073933243","https://openalex.org/W2081097999","https://openalex.org/W2088130891","https://openalex.org/W2093792764","https://openalex.org/W2095549623","https://openalex.org/W2131493069","https://openalex.org/W2318770038","https://openalex.org/W2408888180","https://openalex.org/W2481774961","https://openalex.org/W4252512955","https://openalex.org/W4323239157","https://openalex.org/W6804853166"],"related_works":["https://openalex.org/W2422447100","https://openalex.org/W1979861012","https://openalex.org/W2414012819","https://openalex.org/W2020677450","https://openalex.org/W2532595907","https://openalex.org/W42484951","https://openalex.org/W1988166799","https://openalex.org/W2409697147","https://openalex.org/W2071887047","https://openalex.org/W1998421163"],"abstract_inverted_index":{"Many":[0],"Dermatologic":[1],"disorders":[2],"are":[3,25,38],"associated":[4],"with":[5,57],"the":[6,31,46,52,58,63,71,88,95,101],"acquired":[7],"immune":[8,68],"deficiency":[9],"syndrome":[10],"(AIDS).":[11],"Kaposi\u2019s":[12],"sarcoma,":[13],"psoriasis,":[14],"seborrheic":[15],"dermatitis,":[16],"squamous":[17],"cell":[18,21],"carcinoma,":[19,22],"basal":[20],"and":[23,70,85,94],"melanoma":[24],"all":[26],"increased":[27],"in":[28,30,44],"frequency":[29],"AIDS":[32],"population":[33],"(1,2).":[34],"Multiple":[35],"pathologic":[36],"processes":[37],"likely":[39],"to":[40],"be":[41,98],"at":[42],"work":[43],"inducing":[45],"complex":[47],"manifestations":[48],"of":[49,55,66,73],"AIDS,":[50],"including":[51],"direct":[53],"effects":[54,65],"infection":[56],"human":[59],"immunodeficiency":[60],"virus":[61],"(HIV),":[62],"indirect":[64],"profound":[67],"dysfunction,":[69],"involvement":[72],"multiple":[74],"other":[75],"infectious":[76],"agents":[77],"(3,4).":[78],"These":[79],"keywords":[80,96],"were":[81],"added":[82],"by":[83,87],"machine":[84],"not":[86],"authors.":[89],"This":[90],"process":[91],"is":[92],"experimental":[93],"may":[97],"updated":[99],"as":[100],"learning":[102],"algorithm":[103],"improves.":[104]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
