{"id":"https://openalex.org/W1458771369","doi":null,"title":"Age, Experience, and NMDA Antagonism: Dynamic Regulation of Parvalbumin Expression in Normal and Chronically Ketamine-Treated Rats","display_name":"Age, Experience, and NMDA Antagonism: Dynamic Regulation of Parvalbumin Expression in Normal and Chronically Ketamine-Treated Rats","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1458771369","mag":"1458771369"},"language":"en","primary_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-7021","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/825","pdf_url":"https://opencommons.uconn.edu/dissertations/825","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opencommons.uconn.edu/dissertations/825","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112797400","display_name":"Jennifer A. Corriveau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer A. Corriveau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112797400"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parvalbumin","display_name":"parvalbumin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nmda-receptor-antagonism","display_name":"NMDA receptor antagonism","score":0.8889999985694885},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.7179999947547913},{"id":"https://openalex.org/keywords/age-related-gene-expression","display_name":"age-related gene expression","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9300000071525574},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9950000047683716},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9750000238418579},{"id":"https://openalex.org/keywords/calcium-binding-proteins","display_name":"calcium-binding proteins","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chronic-drug-administration","display_name":"chronic drug administration","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C141547260","wikidata":"https://www.wikidata.org/wiki/Q2720322","display_name":"Parvalbumin","level":2,"score":0.8011831045150757},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.7470804452896118},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5909553170204163},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.507199764251709},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45098671317100525},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39445629715919495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38462206721305847},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36609119176864624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3280259966850281},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07884430885314941}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:opencommons.uconn.edu:dissertations-7021","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/825","pdf_url":"https://opencommons.uconn.edu/dissertations/825","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-7021","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/825","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:1458771369","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/825/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-7021","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/825","pdf_url":"https://opencommons.uconn.edu/dissertations/825","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1458771369.pdf","grobid_xml":"https://content.openalex.org/works/W1458771369.grobid-xml"},"referenced_works_count":174,"referenced_works":["https://openalex.org/W61736868","https://openalex.org/W222438383","https://openalex.org/W1487091206","https://openalex.org/W1515642444","https://openalex.org/W1568625389","https://openalex.org/W1589353809","https://openalex.org/W1593010045","https://openalex.org/W1630370318","https://openalex.org/W1680352201","https://openalex.org/W1716650263","https://openalex.org/W1924706543","https://openalex.org/W1967059763","https://openalex.org/W1968274260","https://openalex.org/W1968303397","https://openalex.org/W1968774575","https://openalex.org/W1970788491","https://openalex.org/W1970958687","https://openalex.org/W1971677675","https://openalex.org/W1971870775","https://openalex.org/W1973311433","https://openalex.org/W1975522748","https://openalex.org/W1978104463","https://openalex.org/W1978748886","https://openalex.org/W1981453653","https://openalex.org/W1983372683","https://openalex.org/W1984454826","https://openalex.org/W1987023439","https://openalex.org/W1988389350","https://openalex.org/W1989973456","https://openalex.org/W1991804233","https://openalex.org/W1992219500","https://openalex.org/W1992902151","https://openalex.org/W1993335821","https://openalex.org/W1993560189","https://openalex.org/W1994475466","https://openalex.org/W1995079626","https://openalex.org/W1997243815","https://openalex.org/W1997765501","https://openalex.org/W1998145134","https://openalex.org/W1999668406","https://openalex.org/W2000232728","https://openalex.org/W2000336335","https://openalex.org/W2000916441","https://openalex.org/W2002192892","https://openalex.org/W2002747593","https://openalex.org/W2006381444","https://openalex.org/W2007031766","https://openalex.org/W2008639041","https://openalex.org/W2009158194","https://openalex.org/W2009444068","https://openalex.org/W2010735491","https://openalex.org/W2013209042","https://openalex.org/W2013400587","https://openalex.org/W2013514700","https://openalex.org/W2017811029","https://openalex.org/W2019479854","https://openalex.org/W2021168080","https://openalex.org/W2021345058","https://openalex.org/W2022759558","https://openalex.org/W2022809683","https://openalex.org/W2023060380","https://openalex.org/W2023145239","https://openalex.org/W2023535204","https://openalex.org/W2024234819","https://openalex.org/W2024913433","https://openalex.org/W2025603247","https://openalex.org/W2026782090","https://openalex.org/W2027691566","https://openalex.org/W2029056592","https://openalex.org/W2030538289","https://openalex.org/W2033829158","https://openalex.org/W2034020074","https://openalex.org/W2034108533","https://openalex.org/W2034650045","https://openalex.org/W2034651412","https://openalex.org/W2035199062","https://openalex.org/W2037549116","https://openalex.org/W2038440451","https://openalex.org/W2039251124","https://openalex.org/W2039602272","https://openalex.org/W2039635263","https://openalex.org/W2039808373","https://openalex.org/W2040806880","https://openalex.org/W2044993165","https://openalex.org/W2045230881","https://openalex.org/W2047564831","https://openalex.org/W2047662887","https://openalex.org/W2047887517","https://openalex.org/W2049973822","https://openalex.org/W2050579962","https://openalex.org/W2052679154","https://openalex.org/W2054802990","https://openalex.org/W2055996490","https://openalex.org/W2056372896","https://openalex.org/W2056903731","https://openalex.org/W2057287270","https://openalex.org/W2057327212","https://openalex.org/W2058140897","https://openalex.org/W2058889376","https://openalex.org/W2058934183","https://openalex.org/W2060589548","https://openalex.org/W2062030838","https://openalex.org/W2062080651","https://openalex.org/W2063522474","https://openalex.org/W2065169750","https://openalex.org/W2066213630","https://openalex.org/W2069566702","https://openalex.org/W2069656785","https://openalex.org/W2070138701","https://openalex.org/W2071090720","https://openalex.org/W2071500495","https://openalex.org/W2072602132","https://openalex.org/W2074067717","https://openalex.org/W2074768932","https://openalex.org/W2075187431","https://openalex.org/W2077117413","https://openalex.org/W2078481226","https://openalex.org/W2080357839","https://openalex.org/W2082707419","https://openalex.org/W2083044172","https://openalex.org/W2084033745","https://openalex.org/W2085139678","https://openalex.org/W2086200816","https://openalex.org/W2089912569","https://openalex.org/W2090206240","https://openalex.org/W2090246683","https://openalex.org/W2091451686","https://openalex.org/W2096192426","https://openalex.org/W2096710308","https://openalex.org/W2099635835","https://openalex.org/W2106126875","https://openalex.org/W2107713038","https://openalex.org/W2110387945","https://openalex.org/W2110978892","https://openalex.org/W2111657752","https://openalex.org/W2112075984","https://openalex.org/W2112572641","https://openalex.org/W2114635736","https://openalex.org/W2115624750","https://openalex.org/W2116087808","https://openalex.org/W2116635659","https://openalex.org/W2117575003","https://openalex.org/W2117586043","https://openalex.org/W2118784177","https://openalex.org/W2119175433","https://openalex.org/W2121398326","https://openalex.org/W2124793944","https://openalex.org/W2125314941","https://openalex.org/W2125788186","https://openalex.org/W2128390612","https://openalex.org/W2128470552","https://openalex.org/W2132748057","https://openalex.org/W2134654456","https://openalex.org/W2140474748","https://openalex.org/W2140606211","https://openalex.org/W2142925815","https://openalex.org/W2143384095","https://openalex.org/W2145728950","https://openalex.org/W2146264275","https://openalex.org/W2152511855","https://openalex.org/W2155832540","https://openalex.org/W2160771103","https://openalex.org/W2163815564","https://openalex.org/W2168362300","https://openalex.org/W2169833225","https://openalex.org/W2170696995","https://openalex.org/W2170774013","https://openalex.org/W2171321840","https://openalex.org/W2171865323","https://openalex.org/W2171907536","https://openalex.org/W2172265909","https://openalex.org/W2400688595","https://openalex.org/W2409407838","https://openalex.org/W2418505138"],"related_works":["https://openalex.org/W2950917491","https://openalex.org/W1997075660","https://openalex.org/W2915313664","https://openalex.org/W2117813547","https://openalex.org/W3098245647","https://openalex.org/W2024234819","https://openalex.org/W1968303397","https://openalex.org/W2018283369","https://openalex.org/W2363056368","https://openalex.org/W2940106254"],"abstract_inverted_index":{"A":[0],"marked":[1],"and":[2,36,44,77,152,225,232,238,256,266,325],"selective":[3],"decrease":[4],"in":[5,21,28,75,110,122,211,310,320],"the":[6,10,41,111,144,166,175,187,234,301,304,321],"overall":[7,261],"expression":[8,124,263,277,312],"of":[9,47,50,83,146,149,169,178,193,198,218,292,323,336],"calcium-binding":[11,29],"protein,":[12],"parvalbumin":[13],"(PV),":[14],"has":[15],"been":[16,69],"a":[17,99,212,251,279,290],"consistent":[18],"postmortem":[19],"finding":[20],"patients":[22],"with":[23,92,113,141],"schizophrenia.":[24],"The":[25,244],"documented":[26],"reduction":[27],"protein":[30],"immunoreactivity":[31,85],"is":[32,37,94,136,278],"specific":[33],"to":[34,71,97,143,158,163,184,228],"PV,":[35],"observed":[38,229],"exclusively":[39],"within":[40,86,180,264],"prefrontal":[42,78],"cortex":[43],"hippocampus":[45],"(HPC)":[46],"patients.":[48],"Models":[49],"schizophreniform":[51],"cognitive":[52,209,230],"dysfunction":[53],"induced":[54],"by":[55],"chronic":[56,199,219,257],"NMDA-receptor":[57],"hypofunction":[58],"utilizing":[59],"non-competitive":[60],"NMDA":[61,127,314],"antagonist":[62,128,315],"drugs":[63],"such":[64],"as":[65,156],"ketamine":[66],"(KET),":[67],"have":[68],"shown":[70],"show":[72],"comparable":[73,126],"decreases":[74],"HPC":[76,265],"cortical":[79],"PV":[80,84,123,159,173,194,223,242,262,276,311,327],"expression.":[81,243],"Down-regulation":[82],"these":[87,170],"key":[88],"brain":[89],"regions":[90],"associated":[91],"cognition":[93],"often":[95],"considered":[96,319],"be":[98,286,318,330],"marker":[100,335],"for":[101],"underlying":[102],"neural":[103],"pathology.":[104],"However,":[105],"contradictory":[106],"findings":[107,245,302],"are":[108],"present":[109,176,305],"literature,":[112],"some":[114],"groups":[115],"reporting":[116],"decreased,":[117],"increased,":[118],"or":[119,333],"no":[120],"change":[121],"following":[125,313],"treatments.":[129],"Upon":[130],"examining":[131],"methodology":[132],"across":[133],"studies,":[134],"it":[135],"clear":[137],"that":[138,275,308,326],"inconsistencies,":[139],"particularly":[140],"regard":[142],"age":[145,237,255],"subjects,":[147],"time":[148],"tissue":[150],"collection,":[151],"treatment-induced":[153],"behavioral":[154],"impairments":[155],"related":[157],"outcomes.":[160],"In":[161],"order":[162],"better":[164],"understand":[165],"distinct":[167],"roles":[168],"factors":[171,293],"on":[172,208,222,241,260,270,289],"expression,":[174,224],"set":[177],"studies":[179],"this":[181],"dissertation":[182],"sought":[183],"elucidate":[185],"upon":[186],"following:":[188],"1)":[189],"age-dependent":[190],"baseline":[191],"regulation":[192],"expression;":[195],"2)":[196],"effect":[197,217],"KET":[200,220,239,258],"treatment":[201,221,259,316],"(30":[202],"mg/kg":[203],"IP;":[204],"14":[205],"consecutive":[206],"days)":[207],"performance":[210],"spatial":[213],"memory":[214],"task;":[215],"3)":[216],"its":[226],"relationship":[227],"impairment;":[231],"4)":[233],"interaction":[235,253],"between":[236,254],"administration":[240],"presented":[246],"herein":[247],"provide":[248],"evidence":[249],"suggesting":[250],"dynamic":[252,281],"neocortical":[267],"regions.":[268],"Based":[269],"our":[271],"data,":[272],"we":[273],"propose":[274],"highly":[280],"neuronal":[282],"marker,":[283],"which":[284],"can":[285],"modulated":[287],"based":[288],"myriad":[291],"(e.g.":[294],"age,":[295,324],"experience,":[296],"treatment,":[297],"etc.).":[298],"Taken":[299],"together,":[300],"from":[303],"work":[306],"suggest":[307],"changes":[309],"should":[317],"context":[322],"may":[328],"not":[329],"an":[331],"accurate":[332],"translational":[334],"pathological":[337],"dysfunction.":[338]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
