{"id":"https://openalex.org/W14581824","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.965.2","title":"Targeting phosphodiesterase 7B and exchange protein directly activated by cAMP\u20101 in chronic lymphocytic leukemia","display_name":"Targeting phosphodiesterase 7B and exchange protein directly activated by cAMP\u20101 in chronic lymphocytic leukemia","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W14581824","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.965.2","mag":"14581824"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.965.2","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.965.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.965.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025629990","display_name":"Fiona Murray","orcid":"https://orcid.org/0000-0002-5572-4810","observed_orcids":["https://orcid.org/0000-0002-5572-4810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fiona Murray","raw_affiliation_strings":["Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071478259","display_name":"Eric A. Apaydin","orcid":"https://orcid.org/0000-0002-3044-9090","observed_orcids":["https://orcid.org/0000-0002-3044-9090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Apaydin","raw_affiliation_strings":["Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100683338","display_name":"Lingzhi Zhang","orcid":"https://orcid.org/0000-0002-3180-8569","observed_orcids":["https://orcid.org/0000-0002-3180-8569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingzhi Zhang","raw_affiliation_strings":["Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033414440","display_name":"Anja Zahno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anja Zahno","raw_affiliation_strings":["Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010336471","display_name":"Laura Z. Rassenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Rassenti","raw_affiliation_strings":["Moores Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J Kipps","raw_affiliation_strings":["Medicine, UCSD, La Jolla, CA","Moores Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, UCSD, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Moores Cancer Center","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055677266","display_name":"Paul A. Insel","orcid":"https://orcid.org/0000-0001-8521-5315","observed_orcids":["https://orcid.org/0000-0001-8521-5315"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A Insel","raw_affiliation_strings":["Medicine, UCSD, La Jolla, CA","Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, UCSD, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Pharmacology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00091258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7689999938011169},{"id":"https://openalex.org/keywords/rap1","display_name":"Rap1","score":0.7559999823570251},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8759999871253967},{"id":"https://openalex.org/keywords/b-cell-leukemia","display_name":"B-cell leukemia","score":0.4869999885559082},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.8145890831947327},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7634038329124451},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.6008689403533936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.545387864112854},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5360456109046936},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.45211589336395264},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42367273569107056},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4220712184906006},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38241371512413025},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3304401636123657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3283834457397461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2796526849269867},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2787713408470154},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21155008673667908},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17862597107887268},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1643509566783905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13814708590507507}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.965.2","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.965.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.965.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1990270711","https://openalex.org/W82315457","https://openalex.org/W3137931715","https://openalex.org/W153972091","https://openalex.org/W2577494631","https://openalex.org/W110644930","https://openalex.org/W2018594176","https://openalex.org/W7098194609","https://openalex.org/W2288636961","https://openalex.org/W2035452022"],"abstract_inverted_index":{"Chronic":[0],"lymphocytic":[1],"leukemia":[2],"(CLL)":[3],"is":[4,16,71],"characterized":[5],"by":[6,62,209,218],"the":[7,28,52,91,162,179,189,196,211,219],"accumulation":[8],"of":[9,22,30,38,54,69,101,111,165,181,191,200,207,214],"B\u2010cells.":[10],"We":[11,88,114],"have":[12],"shown":[13],"that":[14,33,51,100,116,175,194],"CLL":[15,39,74,84,97,112,119,158,192,208],"associated":[17],"with":[18,99,118],"increased":[19],"mRNA":[20,95,131],"expression":[21,53,197],"phosphodiesterase":[23],"7B":[24],"(PDE7B),":[25],"which":[26],"catalyzes":[27],"hydrolysis":[29],"cAMP,":[31,70],"and":[32,79,103,129,160,183,193,198,221,224],"PDE7":[34,215],"inhibitors":[35],"promote":[36],"apoptosis":[37,110,156],"cells":[40,75,85,159],"in":[41,73,77,93,96,127,157],"a":[42,60,66,121],"cAMP/protein":[43],"kinase":[44],"A\u2010dependent":[45],"manner.":[46],"In":[47],"addition,":[48],"we":[49],"find":[50,115],"E":[55],"xchange":[56],"p":[57],"rotein":[58],"directly":[59],"ctivated":[61],"c":[63],"AMP":[64],"(Epac),":[65],"downstream":[67],"mediator":[68],"higher":[72],"than":[76],"normal\u2010PBMC":[78],"B\u2010cells;":[80],"its":[81],"activation":[82],"protects":[83],"from":[86],"apoptosis.":[87],"investigated":[89],"if":[90,104],"increase":[92,108],"PDE7B":[94,128,182],"correlates":[98],"Epac\u20101":[102,130,138,140,184,201],"targeted":[105],"simultaneously":[106],"would":[107],"cAMP\u2010promoted":[109],"cells.":[113],"patients":[117],"show":[120],"significant":[122],"correlation":[123],"between":[124],"their":[125],"fold\u2010increases":[126],"(P<0.001,":[132],"r=0.5395,":[133],"n":[134],"=":[135],"45).":[136],"Inhibiting":[137],"or":[139,146],"signaling":[141],"via":[142],"siRNA":[143],"(48":[144],"hr)":[145],"Rap\u20101":[147],"inhibition":[148,167],"(GGT1\u2010298,":[149],"5":[150],"\u03bcM,":[151],"48":[152,169],"hr),":[153],"respectively,":[154],"induced":[155],"enhanced":[161],"pro\u2010apoptotic":[163,212],"effect":[164],"PDE4/7":[166],"(IR\u2010284,":[168],"hr,":[170],"10nM).":[171],"These":[172],"data":[173],"suggest":[174],"studies":[176],"to":[177],"define":[178],"regulation":[180],"may":[185,202],"provide":[186],"insights":[187],"into":[188],"pathophysiology":[190],"decreasing":[195],"function":[199],"be":[203],"beneficial":[204],"for":[205],"treatment":[206],"increasing":[210],"effects":[213],"inhibitors.":[216],"Supported":[217],"Lymphoma":[220],"Leukemia":[222],"Society":[223],"NIH.":[225]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
