{"id":"https://openalex.org/W145753190","doi":"https://doi.org/10.1007/978-1-59745-366-0_6","title":"Determining MHC Restriction of T-cell Responses","display_name":"Determining MHC Restriction of T-cell Responses","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W145753190","doi":"https://doi.org/10.1007/978-1-59745-366-0_6","mag":"145753190","pmid":"https://pubmed.ncbi.nlm.nih.gov/18615244"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-366-0_6","doi":"https://doi.org/10.1007/978-1-59745-366-0_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-366-0_6","pdf_url":null,"source":{"id":"https://openalex.org/S2756129150","display_name":"Methods in molecular medicine","issn_l":"1543-1894","issn":["1543-1894","1940-6037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Medicine","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2504258211","display_name":"Allergy Methods and Protocols"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077280281","display_name":"Mark Larch\u00e9","orcid":"https://orcid.org/0000-0002-1439-7593","observed_orcids":["https://orcid.org/0000-0002-1439-7593"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mark Larch\u00e9","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077280281"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":1.2956,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.79163008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"138","issue":null,"first_page":"57","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0934000015258789,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-restriction","display_name":"MHC restriction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.8069999814033508},{"id":"https://openalex.org/keywords/peptide-mhc-complex","display_name":"peptide-MHC complex","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hla-class-i","display_name":"HLA class I","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hla-class-ii","display_name":"HLA class II","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8080000281333923},{"id":"https://openalex.org/keywords/fibroblast-cell-lines","display_name":"fibroblast cell lines","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.6169999837875366},{"id":"https://openalex.org/keywords/mhc-polymorphism","display_name":"MHC polymorphism","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5824089050292969},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3971026837825775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3770654499530792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3452844023704529},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2496306598186493},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.17092156410217285}],"mesh":[{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-59745-366-0_6","doi":"https://doi.org/10.1007/978-1-59745-366-0_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-366-0_6","pdf_url":null,"source":{"id":"https://openalex.org/S2756129150","display_name":"Methods in molecular medicine","issn_l":"1543-1894","issn":["1543-1894","1940-6037"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Medicine","raw_type":"book-chapter"},{"id":"pmid:18615244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18615244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1969947900","https://openalex.org/W1985774274","https://openalex.org/W2007608493","https://openalex.org/W2029993034","https://openalex.org/W2129188204","https://openalex.org/W2131333400","https://openalex.org/W2159756478"],"related_works":["https://openalex.org/W202508","https://openalex.org/W3097086375","https://openalex.org/W159512733","https://openalex.org/W2041866663","https://openalex.org/W1522061564","https://openalex.org/W6987652558","https://openalex.org/W2869225","https://openalex.org/W2034629919","https://openalex.org/W7214754411","https://openalex.org/W2061821825"],"abstract_inverted_index":{"T-cell":[0,131,174],"receptors":[1],"(TcR)":[2],"recognize":[3],"short":[4],"linear":[5],"peptides":[6],"(9-15":[7],"amino":[8],"acid":[9],"long),":[10],"which":[11,52,112,141,160],"have":[12],"been":[13],"processed":[14],"by":[15,55],"an":[16],"'antigen-presenting":[17],"cell'":[18],"and":[19,34,47,72,83,85,91,99,168,197],"complexed":[20],"to":[21,38,155,158,171,201],"products":[22],"of":[23,30,43,76,96,104,118,125,135,191],"the":[24,31,41,44,56,148],"major":[25],"histocompatibility":[26],"complex":[27,51],"(MHC).":[28],"Peptides":[29],"appropriate":[32],"shape":[33],"charge":[35],"are":[36,61,127],"able":[37,157],"bind":[39,163],"within":[40],"groove":[42],"MHC":[45,59,100,161,203],"molecule":[46,80],"it":[48,151],"is":[49,53,139],"this":[50,186],"recognized":[54],"TcR.":[57],"The":[58],"molecules":[60,162],"highly":[62],"polymorphic,":[63],"but":[64],"each":[65],"individual":[66],"will":[67,107],"only":[68],"express":[69],"one":[70,73],"maternal":[71],"paternal":[74],"allele":[75],"HLA":[77,86],"Class":[78,87],"1":[79],"A,":[81],"B,":[82],"C":[84],"II":[88],"DR,":[89],"DP,":[90],"DQ.":[92],"As":[93],"a":[94,102,109,114,130,133,164,172],"result":[95],"TcR":[97,126],"specificity":[98],"restriction,":[101],"clone":[103],"T":[105],"cells":[106],"bear":[108],"specific":[110],"receptor":[111],"has":[113],"very":[115],"limited":[116],"repertoire":[117],"targets":[119],"(peptide-MHC":[120],"complexes).":[121],"When":[122,146],"sufficient":[123],"numbers":[124],"engaged":[128],"on":[129],"surface,":[132],"cascade":[134],"signal":[136],"transduction":[137],"events":[138],"initiated":[140],"results":[142],"in":[143,181],"cellular":[144],"activation.":[145],"investigating":[147],"immune":[149],"response,":[150],"may":[152,178],"be":[153,156,179],"advantageous":[154],"identify":[159],"particular":[165],"peptide":[166],"well":[167],"give":[169],"rise":[170],"vigorous":[173],"response.":[175],"Such":[176],"information":[177],"useful":[180],"generating":[182],"effective":[183],"vaccines.":[184],"In":[185],"chapter,":[187],"we":[188],"provide":[189],"examples":[190],"Epstein-Barr":[192],"virus-transformed":[193],"lymphoid":[194],"cell":[195,199],"lines":[196,200],"fibroblast":[198],"determine":[202],"restriction":[204],"elements.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}