{"id":"https://openalex.org/W145688586","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1226.30","title":"Role of PAR2 in Type 2 Diabetes\u2010induced Endothelial Dysfunction","display_name":"Role of PAR2 in Type 2 Diabetes\u2010induced Endothelial Dysfunction","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W145688586","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1226.30","mag":"145688586"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.1226.30","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1226.30","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1226.30","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yoonjung Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoonjung Park","raw_affiliation_strings":["Veterinary Physiology &amp; Pharmacology Texas A&amp;M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Physiology &amp; Pharmacology Texas A&amp;M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026352359","display_name":"Darcey Klaahsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darcey Klaahsen","raw_affiliation_strings":["Veterinary Physiology &amp; Pharmacology Texas A&amp;M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Physiology &amp; Pharmacology Texas A&amp;M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015343493","display_name":"Cuihua Zhang","orcid":"https://orcid.org/0000-0003-2275-4578","observed_orcids":["https://orcid.org/0000-0003-2275-4578"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cuihua Zhang","raw_affiliation_strings":["Veterinary Physiology &amp; Pharmacology Texas A&amp;M University College Station TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary Physiology &amp; Pharmacology Texas A&amp;M University College Station TX","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02384427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease-activated-receptor-2","display_name":"protease-activated receptor 2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8690000176429749},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.7929999828338623},{"id":"https://openalex.org/keywords/coronary-arterioles","display_name":"coronary arterioles","score":0.7160000205039978},{"id":"https://openalex.org/keywords/acetylcholine-induced-vasodilation","display_name":"acetylcholine-induced vasodilation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/flow-induced-vasodilation","display_name":"flow-induced vasodilation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/par2-antagonists","display_name":"PAR2 antagonists","score":0.746999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.640999972820282},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7936217188835144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7924631834030151},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.7340275049209595},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.7146480679512024},{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.6391347050666809},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6272450685501099},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.56880784034729},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.47147491574287415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46069666743278503},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4446662664413452},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4282366633415222},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.42592981457710266},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.41869762539863586},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37966787815093994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3675577640533447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0520634651184082},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.1226.30","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.1226.30","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.1226.30","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039949144","https://openalex.org/W96281085","https://openalex.org/W2765823741","https://openalex.org/W1482716141","https://openalex.org/W2047359653","https://openalex.org/W7099189700","https://openalex.org/W4307038923","https://openalex.org/W2067757134","https://openalex.org/W1497389933","https://openalex.org/W2756183548"],"abstract_inverted_index":{"Previously":[0],"we":[1],"have":[2],"found":[3],"a":[4,53,195],"critical":[5],"role":[6,54,61,197],"of":[7,26,39,62,75,138,164],"tumor":[8],"necrosis":[9],"factor\u2010\u03b1":[10],"(TNF)":[11],"in":[12,55,64,69,122,128,148,168,182,198],"endothelial":[13,47,67,202],"dysfunction":[14,68,203],"resulting":[15],"from":[16],"type":[17,199],"2":[18,71,90,142,200],"diabetes.":[19,72],"Because":[20],"TNF":[21,205],"can":[22],"influence":[23],"many":[24],"pathways":[25],"inducing":[27],"oxidative":[28],"stress":[29],"and":[30,78,86,105,161,177],"cell":[31],"injury,":[32],"our":[33],"goal":[34],"was":[35,99,120,126],"to":[36,51,94,116,134,156,172],"identify":[37],"one":[38],"the":[40,60],"contributing":[41],"mechanisms.":[42],"Protease\u2010activated":[43],"receptors":[44],"(PARs),":[45],"particularly":[46],"PAR2":[48,63,139,165,193],"are":[49],"thought":[50],"play":[52],"inflammatory":[56],"cardiovasculardisease.":[57],"We":[58],"investigated":[59],"regulating":[65],"TNF\u2010induced":[66],"Type":[70],"Coronary":[73],"arterioles":[74],"WT":[76,173],"(normal)":[77],"db/db":[79,104,123,135,149,169],"(diabetic)":[80],"mice":[81,124],"(12\u201316":[82],"weeks)":[83],"were":[84,166,180],"isolated":[85],"pressurized":[87],"(60":[88],"cmH":[89],"O).":[91],"Although":[92],"vasodilation":[93,147,152],"endothelium\u2010independent":[95],"vasodilator":[96],"sodium":[97],"nitroprusside":[98],"not":[100],"different":[101],"among":[102],"WT,":[103],"db":[106,129,183],"TNF\u2010":[107,109,130,132,184,186],"/db":[108,131,185],"(db/db":[110],"null":[111],"for":[112],"TNF)":[113],"mice,":[114],"dilation":[115],"endothelium\u2010dependent":[117],"agonist":[118],"ACh":[119],"impaired":[121],"but":[125],"greater":[127],"compared":[133,171],"(P<0.05).":[136],"Administration":[137],"antagonist":[140],"(FSLLRY\u2010NH":[141],")":[143],"partially":[144],"enhanced":[145],"ACh\u2010induced":[146,157],"mice.":[150],"Flow\u2010induced":[151],"showed":[153],"similar":[154],"response":[155],"vasodilation.":[158],"Both":[159],"mRNA":[160,176],"protein":[162,178],"expression":[163,179],"higher":[167],"heart":[170,174],"whereas":[175],"reduced":[181],"vs":[187],"db/db.":[188],"These":[189],"results":[190],"indicate":[191],"that":[192],"plays":[194],"pivotal":[196],"diabetes\u2010induced":[201],"through":[204],"mechanism.":[206]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}