{"id":"https://openalex.org/W145658961","doi":null,"title":"Reversal of Ubiquitylation: The Role of USP7 and UBP64 in Drosophila Development","display_name":"Reversal of Ubiquitylation: The Role of USP7 and UBP64 in Drosophila Development","publication_year":2008,"publication_date":"2008-04-16","ids":{"openalex":"https://openalex.org/W145658961","mag":"145658961"},"language":"en","primary_location":{"id":"mag:145658961","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/12158/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Prashanth Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prashanth Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025298936","display_name":"Bajpe Rohitha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bajpe Rohitha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01398913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/usp7","display_name":"USP7","score":0.9440000057220459},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.7540000081062317},{"id":"https://openalex.org/keywords/drosophila-development","display_name":"Drosophila development","score":0.9319999814033508},{"id":"https://openalex.org/keywords/chromatin","display_name":"chromatin","score":0.6230000257492065},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.621999979019165},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/histone-variants","display_name":"histone variants","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nucleosome","display_name":"nucleosome","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C173681060","wikidata":"https://www.wikidata.org/wiki/Q5773169","display_name":"Histone octamer","level":5,"score":0.8243101835250854},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.7373266220092773},{"id":"https://openalex.org/C10058791","wikidata":"https://www.wikidata.org/wiki/Q910897","display_name":"Histone code","level":5,"score":0.6785732507705688},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6417192816734314},{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.6242740750312805},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.5855006575584412},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5554712414741516},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5409037470817566},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.5364819765090942},{"id":"https://openalex.org/C164974683","wikidata":"https://www.wikidata.org/wiki/Q1044051","display_name":"Chromatosome","level":5,"score":0.5198381543159485},{"id":"https://openalex.org/C56952853","wikidata":"https://www.wikidata.org/wiki/Q5773144","display_name":"Histone-modifying enzymes","level":5,"score":0.481916218996048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4754186272621155},{"id":"https://openalex.org/C193646685","wikidata":"https://www.wikidata.org/wiki/Q1826830","display_name":"Linker DNA","level":5,"score":0.4528445303440094},{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.4349285960197449},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3989284038543701},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33348414301872253},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3292868435382843},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.1054617166519165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06061214208602905},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:145658961","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/12158/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034869472","https://openalex.org/W2045789125","https://openalex.org/W2341212763","https://openalex.org/W2131343124","https://openalex.org/W4233730562","https://openalex.org/W7098994023","https://openalex.org/W23047450","https://openalex.org/W1992116745","https://openalex.org/W2911683692","https://openalex.org/W1998749998"],"abstract_inverted_index":{"The":[0,12],"genetic":[1],"information":[2],"of":[3,16,23,29,56,76,102],"eukaryotes":[4],"is":[5,18,25],"organised":[6],"in":[7,67],"a":[8],"nucleoprotein":[9],"complex\ncalled":[10],"chromatin.":[11],"fundamental":[13],"repeating":[14],"unit":[15],"chromatin":[17,88,91],"nucleosome":[19,64],"in\nwhich":[20],"146":[21],"bp":[22],"DNA":[24,43],"wrapped":[26],"around":[27],"octamer":[28],"core":[30,58],"histone":[31,98,103],"proteins":[32,51,104],"H2A,\nH2B,":[33],"H3":[34],"and":[35,100],"H4.":[36],"Histone":[37],"H1":[38],"(linker":[39],"histone)":[40],"associates":[41],"with":[42],"between":[44],"two\nnucleosomes.":[45],"Core":[46],"histones":[47,59],"are":[48],"highly":[49],"conserved":[50],"among":[52],"all":[53],"eukaryotes.\nThe":[54],"N-terminus":[55],"the":[57,63,70,74],"extends":[60],"outwards":[61],"from":[62],"and\nis":[65],"\ufb02exible":[66],"nature":[68],"whereas":[69],"globular":[71],"C-terminus":[72],"forms":[73],"scaffold":[75],"the\nnucleosome":[77],"(Fischle":[78],"et":[79],"al.,":[80],"2003).":[81],"Nature":[82],"has":[83],"evolved":[84],"mechanisms":[85],"to":[86],"dynamically\nalter":[87],"structure":[89],"like":[90],"remodelling":[92],"by":[93],"ATP":[94],"dependent":[95],"chromatin\nremodellers,":[96],"covalent":[97],"modifications,":[99],"replacement":[101],"by\ntheir":[105],"respective":[106],"variants.":[107]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}