{"id":"https://openalex.org/W145488519","doi":null,"title":"Comparative diuretic activity of delta9-tetrahydrocannabinol, cannabidiol, cannabinol and hydrochlorothiazide in the rat.","display_name":"Comparative diuretic activity of delta9-tetrahydrocannabinol, cannabidiol, cannabinol and hydrochlorothiazide in the rat.","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W145488519","mag":"145488519","pmid":"https://pubmed.ncbi.nlm.nih.gov/849066"},"language":"en","primary_location":{"id":"pmid:849066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/849066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives internationales de pharmacodynamie et de therapie","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034730471","display_name":"Sofia Rd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Sofia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021527641","display_name":"Linda C. Knobloch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L C Knobloch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067290895","display_name":"J J Harakal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Harakal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033945870","display_name":"D. J. Erikson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D J Erikson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.01186304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"225","issue":"1","first_page":"77","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delta9-tetrahydrocannabinol","display_name":"delta-9-tetrahydrocannabinol","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cannabinol","display_name":"cannabinol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/diuretic-activity","display_name":"diuretic activity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/urine-output","display_name":"urine output","score":0.8799999952316284},{"id":"https://openalex.org/keywords/electrolyte-excretion","display_name":"electrolyte excretion","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/urinary-potassium-excretion","display_name":"potassium excretion","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chloride-excretion","display_name":"chloride excretion","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hypophysectomy","display_name":"hypophysectomy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":1.0},{"id":"https://openalex.org/keywords/tolerance-pharmacology-and-immunology","display_name":"tolerance (pharmacology and immunology)","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cannabinoids","display_name":"cannabinoids","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.8840432167053223},{"id":"https://openalex.org/C2780361556","wikidata":"https://www.wikidata.org/wiki/Q423930","display_name":"Hydrochlorothiazide","level":3,"score":0.7905905246734619},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7014480829238892},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.635267972946167},{"id":"https://openalex.org/C2776895053","wikidata":"https://www.wikidata.org/wiki/Q422917","display_name":"Cannabidiol","level":3,"score":0.607646107673645},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6011475324630737},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5073499083518982},{"id":"https://openalex.org/C2781090866","wikidata":"https://www.wikidata.org/wiki/Q265831","display_name":"Cannabinol","level":4,"score":0.49732473492622375},{"id":"https://openalex.org/C2778563155","wikidata":"https://www.wikidata.org/wiki/Q190067","display_name":"Tetrahydrocannabinol","level":4,"score":0.4873135983943939},{"id":"https://openalex.org/C2908858883","wikidata":"https://www.wikidata.org/wiki/Q2705066","display_name":"Dronabinol","level":4,"score":0.47932636737823486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45919856429100037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4517943859100342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22624078392982483},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.16916325688362122},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1275537610054016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07015252113342285},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.05513158440589905},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002187","descriptor_name":"Cannabinol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002187","descriptor_name":"Cannabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006852","descriptor_name":"Hydrochlorothiazide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006852","descriptor_name":"Hydrochlorothiazide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:849066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/849066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives internationales de pharmacodynamie et de therapie","raw_type":"Comparative Study"},{"id":"mag:145488519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/849066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1973408853","https://openalex.org/W2403377312","https://openalex.org/W2314692757","https://openalex.org/W2539262356","https://openalex.org/W2404610490","https://openalex.org/W2366206204","https://openalex.org/W2058943870","https://openalex.org/W2037080534","https://openalex.org/W2964730643","https://openalex.org/W2405182196"],"abstract_inverted_index":{"Orally":[0],"administered":[1],"delta9-tetrahydrocannabinol":[2],"(THC)":[3],"produced":[4],"a":[5,51],"dose-dependent":[6],"increase":[7,37],"in":[8,11,15,38],"urine":[9,99,111],"output":[10,100,112],"hydrated":[12],"rats":[13],"similar":[14],"mg/kg":[16],"potency":[17],"and":[18,33,35,56,71,83,113],"magnitude":[19],"of":[20,30,77,86,92,107,122],"effect":[21,53,76,91,97],"to":[22,95],"hydrochlorothiazide":[23],"(HCT).":[24],"Whereas":[25],"HCT":[26,123],"promoted":[27],"marked":[28],"excretion":[29,58,115],"Na+,":[31],"K+":[32,57],"Cl-":[34,61],"an":[36],"the":[39,64,74,89,96],"urinary":[40],"Na+/K+":[41],"at":[42],"all":[43],"diuretic":[44,75,90],"doses":[45],"(1.25-20.0":[46],"mg/kg),":[47],"THC":[48,102],"had":[49],"only":[50],"slight":[52],"on":[54,98],"Na+":[55],"but":[59],"not":[60],"even":[62],"after":[63,104,119],"highest":[65],"dose":[66],"tested":[67],"(20.0":[68],"mg/kg).":[69],"Hypophysectomy":[70],"adrenalectomy":[72],"abolished":[73],"THC,":[78],"thus":[79],"suggesting":[80],"both":[81],"central":[82],"peripheral":[84],"sites":[85],"action":[87],"for":[88],"THC.":[93],"Tolerance":[94],"by":[101],"developed":[103],"15":[105],"days":[106,121],"repeated":[108],"dosing,":[109],"while":[110],"electrolyte":[114],"remained":[116],"significantly":[117],"elevated":[118],"25":[120],"administration.":[124]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
