{"id":"https://openalex.org/W14542269","doi":null,"title":"Effect of D-penicillamine on liver fibrosis and inflammation in Wilson disease.","display_name":"Effect of D-penicillamine on liver fibrosis and inflammation in Wilson disease.","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W14542269","mag":"14542269","pmid":"https://pubmed.ncbi.nlm.nih.gov/19338486"},"language":"en","primary_location":{"id":"pmid:19338486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19338486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057553751","display_name":"Kourosh Kazemi","orcid":"https://orcid.org/0000-0003-4477-7121","observed_orcids":["https://orcid.org/0000-0003-4477-7121"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kourosh Kazemi","raw_affiliation_strings":["Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053554120","display_name":"Bita Geramizadeh","orcid":"https://orcid.org/0000-0002-4867-5686","observed_orcids":["https://orcid.org/0000-0002-4867-5686","https://orcid.org/0000-0003-1009-0049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bita Geramizadeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103825675","display_name":"Saman Nikeghbalian","orcid":"https://orcid.org/0000-0003-4530-8829","observed_orcids":["https://orcid.org/0000-0003-4530-8829","https://orcid.org/0000-0001-9159-8586","https://orcid.org/0009-0007-3195-0171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saman Nikeghbalian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000288398","display_name":"H Salahi","orcid":"https://orcid.org/0000-0002-2516-6029","observed_orcids":["https://orcid.org/0000-0002-2516-6029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heshmatollah Salahi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079257337","display_name":"Ali Bahador","orcid":"https://orcid.org/0000-0002-3840-0945","observed_orcids":["https://orcid.org/0000-0002-3840-0945","https://orcid.org/0000-0002-5099-7967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali Bahador","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051166894","display_name":"Seyed Mohammad Reza Nejatollahi","orcid":"https://orcid.org/0000-0003-0597-0703","observed_orcids":["https://orcid.org/0000-0003-0597-0703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seyed Mohammad Reza Nejatollahi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Seyed Mohsen Dehghani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seyed Mohsen Dehghani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063286937","display_name":"Masood Dehghani","orcid":"https://orcid.org/0000-0001-8999-8839","observed_orcids":["https://orcid.org/0000-0001-8999-8839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masood Dehghani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032548942","display_name":"Farzad Kakaei","orcid":"https://orcid.org/0000-0003-1632-7393","observed_orcids":["https://orcid.org/0000-0003-1632-7393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farzad Kakaei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065089798","display_name":"Seyed Ali Malek\u2010Hosseini","orcid":"https://orcid.org/0000-0002-0853-9938","observed_orcids":["https://orcid.org/0000-0002-0853-9938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seyed Ali Malek-Hosseini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2843,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.62512349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"6","issue":"4","first_page":"261","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wilson-s-disease","display_name":"Wilson's disease","score":0.9089999794960022},{"id":"https://openalex.org/keywords/penicillamine","display_name":"D-penicillamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/copper-metabolism","display_name":"copper metabolism","score":0.7129999995231628},{"id":"https://openalex.org/keywords/atp7b","display_name":"ATP7B","score":0.8339999914169312},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/copper-overload","display_name":"copper overload","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2779348387","wikidata":"https://www.wikidata.org/wiki/Q421239","display_name":"Penicillamine","level":2,"score":0.9240898489952087},{"id":"https://openalex.org/C2776231509","wikidata":"https://www.wikidata.org/wiki/Q117121","display_name":"Wilson's disease","level":3,"score":0.7853739857673645},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6559188961982727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6239446997642517},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5966472625732422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5790531635284424},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.437456876039505},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41791510581970215}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006505","descriptor_name":"Hepatitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006505","descriptor_name":"Hepatitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006505","descriptor_name":"Hepatitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006527","descriptor_name":"Hepatolenticular Degeneration","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006527","descriptor_name":"Hepatolenticular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006527","descriptor_name":"Hepatolenticular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006527","descriptor_name":"Hepatolenticular Degeneration","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010396","descriptor_name":"Penicillamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19338486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19338486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4372286349","https://openalex.org/W1969906204","https://openalex.org/W161871065","https://openalex.org/W1993337379","https://openalex.org/W2045274921","https://openalex.org/W2315023718","https://openalex.org/W2406264694","https://openalex.org/W1975721815","https://openalex.org/W2409389686","https://openalex.org/W2415222463"],"abstract_inverted_index":{"BACKGROUND:":[0],"Wilson":[1,79,145,292],"disease":[2,80,146],"is":[3],"a":[4,25,91,148,159],"disorder":[5],"of":[6,21,51,73,107,114,151,161,200,224,236,250,261,286],"copper":[7,11,28,36],"metabolism":[8],"characterized":[9],"by":[10,131],"overload.":[12],"A":[13],"mutation":[14],"in":[15,27,33,54,61,196,211,216,222,266,273,289],"the":[16,31,49,55,70,179,204,225,229,251,267,274,284],"ATP7B":[17,22],"gene":[18],"causes":[19],"dysfunction":[20],"protein":[23],"and":[24,47,86,116,125,128,191,198,219,245,256],"reduction":[26],"excretion":[29],"into":[30,100],"bile":[32],"hepatocytes.":[34],"Excess":[35],"accumulation":[37],"leads":[38],"to":[39,104,170],"liver":[40,92,165,287],"injury.":[41],"D-penicillamine":[42,108,162,180,205,231,268,281],"primarily":[43],"can":[44],"inhibit":[45],"fibrogenesis":[46,288],"prevent":[48],"appearance":[50],"scar":[52],"lesions":[53],"liver.":[56],"We":[57],"studied":[58],"this":[59],"phenomenon":[60],"our":[62],"patients.":[63],"MATERIALS":[64],"AND":[65],"METHODS:":[66],"Pathology":[67],"slides":[68],"from":[69,167],"explanted":[71],"livers":[72],"26":[74,137],"patients":[75,138,183,226,252,290],"diagnosed":[76],"as":[77,120],"having":[78],"with":[81,147,291],"hepatoneurologic":[82],"manifestations":[83],"between":[84],"2000":[85],"2008":[87],"who":[88,143],"had":[89,144,158,185,253],"undergone":[90],"transplant":[93,166],"were":[94,98,118,129,238],"investigated":[95],"retrospectively.":[96],"Patients":[97],"divided":[99],"2":[101,190,215,243,255],"groups":[102],"according":[103],"their":[105],"history":[106,160],"use":[109,163],"before":[110,164],"transplant.":[111],"The":[112,259],"degree":[113,260],"fibrosis":[115,193,237,262],"inflammation":[117,207],"classified":[119],"mild":[121],"(1),":[122],"moderate":[123],"(2),":[124],"severe":[126],"(3),":[127],"reviewed":[130],"an":[132],"impartial":[133],"hepatopathologist.":[134],"RESULTS:":[135],"Of":[136],"(20":[139],"male,":[140],"6":[141,168],"female)":[142],"mean":[149],"age":[150],"17.6":[152],"-/+":[153,175],"8.6":[154],"years,":[155],"69%":[156],"(18/26)":[157],"months":[169],"9":[171],"years":[172],"(mean,":[173],"3.4":[174],"2.7":[176],"years).":[177],"In":[178,203,228],"group,":[181,206],"14":[182],"(77%)":[184],"grade":[186,209,214,220,239,242,246,254],"1":[187,221,247],"fibrosis.":[188],"Grade":[189],"3":[192,210,240,257],"was":[194,208,263,272],"seen":[195],"5.6%":[197],"16%":[199],"patients,":[201],"respectively.":[202],"44%":[212,217],"(8/18),":[213,218],"11%":[223],"(2/18).":[227],"non-":[230],"group":[232,269,276],"(8":[233],"patients),":[234],"grades":[235],"(62%),":[241],"(25%),":[244],"(12%);":[248],"87%":[249],"inflammation.":[258],"significantly":[264],"lower":[265],"than":[270],"it":[271],"non-D-penicillamine":[275],"(P":[277],"<":[278],".05).":[279],"CONCLUSION:":[280],"may":[282],"reduce":[283],"rate":[285],"disease.":[293]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
