{"id":"https://openalex.org/W14528299","doi":"https://doi.org/10.1161/circ.128.suppl_22.a18354","title":"Abstract 18354: Chronic Pressure-Dependent Cardiac Unloading With a Novel Intra-Atrial Shunt (V-Wave Device) in an Ovine Model of Ischemic Heart Failure: Evidence for Shunt-mediated Improvements in Function and Survivability","display_name":"Abstract 18354: Chronic Pressure-Dependent Cardiac Unloading With a Novel Intra-Atrial Shunt (V-Wave Device) in an Ovine Model of Ischemic Heart Failure: Evidence for Shunt-mediated Improvements in Function and Survivability","publication_year":2013,"publication_date":"2013-11-26","ids":{"openalex":"https://openalex.org/W14528299","doi":"https://doi.org/10.1161/circ.128.suppl_22.a18354","mag":"14528299"},"language":"en","primary_location":{"id":"doi:10.1161/circ.128.suppl_22.a18354","doi":"https://doi.org/10.1161/circ.128.suppl_22.a18354","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.128.suppl_22.a18354","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002864404","display_name":"Carlos L. del Rio","orcid":"https://orcid.org/0000-0002-9761-7888","observed_orcids":["https://orcid.org/0000-0002-9761-7888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos L del Rio","raw_affiliation_strings":["Safety &amp; Pharmacology, QTest Labs, Columbus, OH","Carlos L del Rio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety &amp; Pharmacology, QTest Labs, Columbus, OH","institution_ids":[]},{"raw_affiliation_string":"Carlos L del Rio","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081030178","display_name":"Patrick I. McConnell","orcid":"https://orcid.org/0000-0001-5349-1040","observed_orcids":["https://orcid.org/0000-0001-5349-1040"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick I McConnell","raw_affiliation_strings":["Cardiothoracic Surgery, Nationwide Children\u2019s Hosp, Columbus, OH","Patrick I McConnell"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoracic Surgery, Nationwide Children\u2019s Hosp, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"Patrick I McConnell","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017166370","display_name":"Yaacov Nitzan","orcid":"https://orcid.org/0000-0002-0151-8915","observed_orcids":["https://orcid.org/0000-0002-0151-8915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaacov Nitzan","raw_affiliation_strings":["CTO, V-Wave LTD, Hod Hasahron, Israel","Yaacov Nitzan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CTO, V-Wave LTD, Hod Hasahron, Israel","institution_ids":[]},{"raw_affiliation_string":"Yaacov Nitzan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046429160","display_name":"Yukie Ueyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukie Ueyama","raw_affiliation_strings":["Safety &amp; Pharmacology, QTest Labs, Columbus, OH","Yukie Ueyama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety &amp; Pharmacology, QTest Labs, Columbus, OH","institution_ids":[]},{"raw_affiliation_string":"Yukie Ueyama","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090312042","display_name":"Pamela Kloepfer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pamela Kloepfer","raw_affiliation_strings":["Safety &amp; Pharmacology, QTest Labs, Columbus, OH","Pamela Kloepfer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety &amp; Pharmacology, QTest Labs, Columbus, OH","institution_ids":[]},{"raw_affiliation_string":"Pamela Kloepfer","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113617352","display_name":"Bradley L. Youngblood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradley L Youngblood","raw_affiliation_strings":["Safety &amp; Pharmacology, QTest Labs, Columbus, OH","Bradley L Youngblood"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety &amp; Pharmacology, QTest Labs, Columbus, OH","institution_ids":[]},{"raw_affiliation_string":"Bradley L Youngblood","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert George","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert George","raw_affiliation_strings":["Safety &amp; Pharmacology, QTest Labs, Columbus, OH","Robert George"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety &amp; Pharmacology, QTest Labs, Columbus, OH","institution_ids":[]},{"raw_affiliation_string":"Robert George","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020750006","display_name":"Meni Jacoby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meni Jacoby","raw_affiliation_strings":["Rsch &amp; Development, V-Wave LTD, Hod Hasahron, Israel","Meni Jacoby"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rsch &amp; Development, V-Wave LTD, Hod Hasahron, Israel","institution_ids":[]},{"raw_affiliation_string":"Meni Jacoby","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048833151","display_name":"Robert L. Hamlin","orcid":"https://orcid.org/0000-0002-6296-7917","observed_orcids":["https://orcid.org/0000-0002-6296-7917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert L Hamlin","raw_affiliation_strings":["Safety &amp; Pharmacology, QTest Labs, Columbus, OH","Robert L Hamlin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety &amp; Pharmacology, QTest Labs, Columbus, OH","institution_ids":[]},{"raw_affiliation_string":"Robert L Hamlin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108485764","display_name":"Orna Oz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Orna Oz","raw_affiliation_strings":["Rsch &amp; Development, BioMed Strategy LTD, Hod Hasahron, Israel","Orna Oz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rsch &amp; Development, BioMed Strategy LTD, Hod Hasahron, Israel","institution_ids":[]},{"raw_affiliation_string":"Orna Oz","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109285043","display_name":"Gad Keren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gad Keren","raw_affiliation_strings":["Reseach &amp; Development, V-Wave LTD, Hod Hasahron, Israel","Gad Keren"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reseach &amp; Development, V-Wave LTD, Hod Hasahron, Israel","institution_ids":[]},{"raw_affiliation_string":"Gad Keren","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079278619","display_name":"Stefan Verheye","orcid":"https://orcid.org/0000-0002-2182-1065","observed_orcids":["https://orcid.org/0000-0002-2182-1065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Verheye","raw_affiliation_strings":["Rsch &amp; Development, V-Wave LTD, Hod Hasahron, Israel","Stefan Verheye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rsch &amp; Development, V-Wave LTD, Hod Hasahron, Israel","institution_ids":[]},{"raw_affiliation_string":"Stefan Verheye","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066384461","display_name":"William T. Abraham","orcid":"https://orcid.org/0000-0003-4805-1037","observed_orcids":["https://orcid.org/0000-0003-4805-1037"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T Abraham","raw_affiliation_strings":["Div of Cardiology, The Ohio State Univ, Columbus, OH","William T Abraham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Div of Cardiology, The Ohio State Univ, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"William T Abraham","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"128","issue":"suppl_22","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.48969998955726624,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.18289999663829803,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-heart-failure","display_name":"ischemic heart failure","score":0.9470000267028809},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.7799999713897705},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.6899999976158142},{"id":"https://openalex.org/keywords/coronary-embolization","display_name":"coronary embolization","score":0.722000002861023},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.6729999780654907},{"id":"https://openalex.org/keywords/shunt-patency","display_name":"shunt patency","score":0.6859999895095825},{"id":"https://openalex.org/keywords/left-atrial-pressure","display_name":"left atrial pressure","score":0.6809999942779541},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cardiac-assist-devices","display_name":"cardiac assist devices","score":0.36399999260902405},{"id":"https://openalex.org/keywords/left-to-right-shunt","display_name":"left-to-right shunt","score":0.5960000157356262},{"id":"https://openalex.org/keywords/fossa-ovalis","display_name":"fossa ovalis","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9490488767623901},{"id":"https://openalex.org/C2780968331","wikidata":"https://www.wikidata.org/wiki/Q1890115","display_name":"Shunt (medical)","level":2,"score":0.743414044380188},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7357668280601501},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6767878532409668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6604450941085815},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5369678735733032}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.128.suppl_22.a18354","doi":"https://doi.org/10.1161/circ.128.suppl_22.a18354","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.128.suppl_22.a18354","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131822904","https://openalex.org/W2739017924","https://openalex.org/W1968096224","https://openalex.org/W2416123847","https://openalex.org/W3126910303","https://openalex.org/W4205639238","https://openalex.org/W2531132270","https://openalex.org/W4383106607","https://openalex.org/W4386169096","https://openalex.org/W3012730549"],"abstract_inverted_index":{"Introduction:":[0],"Progressive":[1],"elevations":[2],"in":[3,36,55,72,109,198,230,241,249,279,296],"left-ventricular":[4],"(LV)":[5],"filling":[6,223,287],"pressures,":[7,152,288,291],"as":[8,48,124],"occurring":[9],"during":[10],"heart":[11,303],"failure":[12],"(HF),":[13],"increase":[14],"myocardial":[15],"energy":[16],"demand":[17],"and":[18,33,103,114,153,233,292],"facilitate":[19],"maladaptive":[20],"remodeling.":[21],"We":[22],"hypothesized":[23],"that":[24],"chronic":[25,58,73,299],"selective":[26],"left-atrial":[27,171],"unloading":[28],"can":[29],"mitigate":[30],"LV":[31,154,206,235,294],"remodeling":[32],"functional":[34],"deterioration":[35],"HF.":[37,60],"Hence,":[38],"we":[39],"studied":[40],"a":[41,49,91,269,280,297],"novel":[42,270],"intra-atrial":[43,271],"device":[44,134],"designed":[45,273],"to":[46,78,82,111,122,162,175,210,274,284],"act":[47],"selective/pressure-dependent":[50],"one-way":[51],"(left-to-right)":[52],"shunt,":[53],"implanted":[54],"sheep":[56,87,203,220],"with":[57,93],"ischemic":[59,302],"Methods:":[61],"Sheep":[62],"(45":[63],"\u00b1":[64],"2":[65],"Kg)":[66],"underwent":[67],"serial/selective":[68],"coronary":[69],"embolizations":[70],"resulting":[71],"left":[74,101],"HF":[75],"(EF:":[76,237],"65\u00b11":[77],"36\u00b11%,":[79],"LVIDd:":[80],"3.5\u00b10.1":[81],"4.9\u00b10.1":[83],"cm;":[84],"P<0.05).":[85,200],"Subsequently,":[86],"were":[88,119,157,185],"instrumented":[89],"via":[90],"thoracotomy":[92],"indwelling":[94],"catheters":[95],"into":[96,139],"the":[97,100,104,132,140,188,191,216,246,258,262,277],"pulmonary":[98],"artery,":[99],"atrium,":[102],"right":[105],"atrium/superior":[106],"vena":[107],"cava":[108],"order":[110],"monitor":[112],"pressures":[113,172,224],"oxygen":[115],"saturations.":[116],"The":[117,166,266],"animals":[118,251],"assigned":[120],"either":[121],"serve":[123],"controls":[125,260],"(CTRL,":[126],"n":[127],"=":[128,136],"7)":[129],"or":[130],"had":[131,204,221],"V-Wave":[133,267],"(n":[135],"14)":[137],"deployed":[138,167],"fossa":[141],"ovalis.":[142],"After":[143],"recovery,":[144],"valved-shunt":[145],"patency":[146],"(via":[147],"Fick\u2019s":[148],"method),":[149],"mean":[150],"atrial/pulmonary":[151],"function":[155,236,295],"(echocardiography)":[156],"evaluated":[158],"weekly":[159],"for":[160,187],"up":[161],"12":[163],"weeks.":[164],"Results:":[165],"shunts":[168,184],"acutely":[169],"lowered":[170],"(LAP,":[173],"17\u00b11":[174],"14\u00b11":[176,226],"mmHg,":[177],"P<0.05)":[178,232,243],"without":[179],"increasing":[180],"right-atrial/pulmonary-artery":[181],"pressures.":[182],"Implanted":[183],"patent":[186],"duration":[189],"of":[190,257,301],"study":[192],"(mean":[193],"Qp/Qs:":[194],"1.17\u00b10.03":[195],"vs":[196],"0.76\u00b10.03":[197],"CTRL,":[199,231,242],"Chronically,":[201],"shunt-treated":[202],"improved":[205,293],"loading/function":[207],"when":[208],"compared":[209],"controls,":[211],"which":[212],"progressively":[213],"deteriorated;":[214],"over":[215],"12-week":[217,247],"study,":[218],"treated":[219,250],"lower":[222],"(LAP:":[225],"vs.":[227,239],"22\u00b12":[228],"mmHg":[229],"preserved":[234,289],"42\u00b13":[238],"25\u00b12%":[240],".":[244],"Notably,":[245],"survival":[248],"was":[252],"93%,":[253],"while":[254],"only":[255],"57%":[256],"untreated":[259],"survived":[261],"monitoring":[263],"period.":[264],"Conclusion:":[265],"device,":[268],"shunt":[272],"selectively":[275],"unload":[276],"left-heart":[278],"pressure-dependent":[281],"manner,":[282],"lead":[283],"chronically":[285],"reduced":[286],"right-sided":[290],"clinically-relevant":[298],"model":[300],"failure.":[304]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
