{"id":"https://openalex.org/W145232249","doi":null,"title":"Gap junctional communication and neoplastic transformation.","display_name":"Gap junctional communication and neoplastic transformation.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W145232249","mag":"145232249","pmid":"https://pubmed.ncbi.nlm.nih.gov/8241323"},"language":"en","primary_location":{"id":"pmid:8241323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8241323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in oncogenesis","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081292832","display_name":"Agnes Hotz\u2010Wagenblatt","orcid":"https://orcid.org/0000-0003-1523-2093","observed_orcids":["https://orcid.org/0000-0003-1523-2093"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Hotz-Wagenblatt","raw_affiliation_strings":["Department of Pathology, Cornell University, Ithaca, NY 14853"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Cornell University, Ithaca, NY 14853","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040048681","display_name":"David I. Shalloway","orcid":"https://orcid.org/0000-0001-8757-7440","observed_orcids":["https://orcid.org/0000-0001-8757-7440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Shalloway","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9803,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.71785125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"5","first_page":"541","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gap-junctional-intercellular-communication","display_name":"gap junctional intercellular communication","score":0.9700000286102295},{"id":"https://openalex.org/keywords/connexins","display_name":"connexins","score":0.9440000057220459},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.875},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.796999990940094},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6480000019073486},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.9390000104904175},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.921999990940094},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.6230000257492065},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.6819999814033508},{"id":"https://openalex.org/keywords/adenovirus-e1a","display_name":"adenovirus E1A","score":0.8519999980926514},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7770000100135803},{"id":"https://openalex.org/keywords/fos","display_name":"FOS","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-growth-control","display_name":"tumor growth control","score":0.5879999995231628},{"id":"https://openalex.org/keywords/oncogene-transformed-cells","display_name":"oncogene-transformed cells","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.6137616038322449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5996325612068176},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5533542037010193},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5275079011917114},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.5258867144584656},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.49568378925323486},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.49505653977394104},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.47602537274360657},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.4464094042778015},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3961532711982727},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3955420255661011},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3531002998352051},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3374934792518616},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3163742423057556},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2748846411705017},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22502869367599487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1390637755393982},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12889036536216736}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8241323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8241323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in oncogenesis","raw_type":"Journal Article"},{"id":"mag:145232249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8241323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2096905216","display_name":"INTERACTION OF SRC AND OTHER PROTEINS IN TRANSFORMATION","funder_award_id":"R01CA047333","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4163128144","display_name":"REGULATION/ACTIVATION OF C-SRC TRANSFORMING ACTIVITY","funder_award_id":"K04CA001139","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2354662761","https://openalex.org/W2161016685","https://openalex.org/W1705946321","https://openalex.org/W2339312596","https://openalex.org/W2069697435","https://openalex.org/W2086439895","https://openalex.org/W2414381347","https://openalex.org/W2052340847","https://openalex.org/W2417951371","https://openalex.org/W2027321340"],"abstract_inverted_index":{"Gap":[0],"junctional":[1],"communication":[2,52],"(GJC)":[3],"is":[4],"mediated":[5],"by":[6,16,142,156],"channels":[7],"consisting":[8],"of":[9,75,83,86,145,173,196],"connexins":[10],"and":[11,22,28,49,56,122,131,164,180,186,200],"can":[12,109,126,183],"be":[13,127,154],"differentially":[14],"regulated":[15,128],"ions,":[17],"second":[18,87],"messengers,":[19],"kinases,":[20],"phosphatases,":[21],"cell":[23,94,106],"adhesion":[24,107],"molecules.":[25],"Tumor":[26],"cells":[27,30,55,182],"oncogene-transformed":[29,134],"often,":[31],"but":[32,66,113,161],"not":[33,118,162],"always,":[34],"show":[35],"reduced":[36,50],"homologous":[37],"GJC":[38,60,139,151,167,185,197],"between":[39,47,53],"themselves.":[40],"A":[41],"more":[42],"stringent":[43],"correlation":[44],"may":[45,79],"exist":[46],"transformation":[48,199],"heterologous":[51],"transformed":[54],"normal":[57],"neighbors.":[58],"Reduced":[59],"seems":[61],"to":[62,153,168],"stimulate":[63],"tumor":[64],"promotion":[65],"has":[67,117],"no":[68],"significant":[69],"effect":[70],"on":[71],"the":[72,81],"initiation":[73],"phase":[74],"carcinogenesis.":[76],"These":[77,191],"effects":[78],"reflect":[80],"importance":[82],"intercellular":[84],"passage":[85],"messengers":[88],"or":[89],"other":[90],"small":[91],"molecules":[92,108],"in":[93,103,133,140,150,175,198],"growth":[95,188,201],"control.":[96,202],"Some":[97],"evidence":[98],"suggests":[99],"that":[100],"gap":[101,123],"junction":[102,124],"combination":[104],"with":[105],"affect":[110],"metastatic":[111],"potential,":[112],"a":[114],"clear":[115],"picture":[116],"yet":[119],"emerged.":[120],"Coupling":[121],"expression":[125,172],"both":[129],"pre-":[130],"posttranslationally":[132],"cells.":[135],"Src":[136],"probably":[137],"downregulates":[138,166],"fibroblasts":[141],"tyrosine":[143],"phosphorylation":[144],"connexin43.":[146],"The":[147],"Ras-induced":[148],"reduction":[149],"appears":[152],"caused":[155],"decreased":[157],"connexin":[158,174],"expression.":[159],"E1A,":[160],"Myc":[163],"Fos,":[165],"some":[169],"extent.":[170],"Artificial":[171],"glioma,":[176],"hepatoma,":[177],"chemically":[178],"transformed,":[179],"src-transformed":[181],"restore":[184],"suppress":[187],"and/or":[189],"tumorigenesis.":[190],"results":[192],"argue":[193],"for":[194],"involvement":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}