{"id":"https://openalex.org/W145218246","doi":null,"title":"Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice.","display_name":"Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice.","publication_year":1976,"publication_date":"1976-11-01","ids":{"openalex":"https://openalex.org/W145218246","mag":"145218246","pmid":"https://pubmed.ncbi.nlm.nih.gov/11695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032573"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2032573","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032573","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032573","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069036413","display_name":"Eugenie S. Kleinerman","orcid":"https://orcid.org/0000-0003-4280-3031","observed_orcids":["https://orcid.org/0000-0003-4280-3031"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E S Kleinerman","raw_affiliation_strings":["Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063633183","display_name":"Charles A. Daniels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Daniels","raw_affiliation_strings":["Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R P Polisson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R P Polisson","raw_affiliation_strings":["Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020405246","display_name":"Ralph Snyderman M. D","orcid":"https://orcid.org/0009-0003-5252-5036","observed_orcids":["https://orcid.org/0009-0003-5252-5036"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Snyderman","raw_affiliation_strings":["Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":2.3756,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.87140359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"85","issue":"2","first_page":"373","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza","display_name":"influenza","score":0.8510000109672546},{"id":"https://openalex.org/keywords/macrophage-accumulation","display_name":"macrophage accumulation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.824999988079071},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6679999828338623},{"id":"https://openalex.org/keywords/macrophage-chemotaxis","display_name":"macrophage chemotaxis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.9160000085830688},{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/bacterial-pneumonia","display_name":"bacterial pneumonia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/leukocyte-accumulation","display_name":"leukocyte accumulation","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7419580221176147},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7035315632820129},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7030165195465088},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6596304178237915},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6367045640945435},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6056113839149475},{"id":"https://openalex.org/C2778536324","wikidata":"https://www.wikidata.org/wiki/Q1030169","display_name":"Peritoneal cavity","level":2,"score":0.5592827796936035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5120404362678528},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5050809979438782},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.4938231408596039},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4677313268184662},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.37439751625061035},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3688691556453705},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2032573","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032573","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:11695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:145218246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2032573","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032573","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1517095907","https://openalex.org/W1527319087","https://openalex.org/W1572068036","https://openalex.org/W1607461883","https://openalex.org/W1823620251","https://openalex.org/W1926355978","https://openalex.org/W1984772634","https://openalex.org/W2000362479","https://openalex.org/W2013858124","https://openalex.org/W2019628696","https://openalex.org/W2032167504","https://openalex.org/W2046669246","https://openalex.org/W2092800429","https://openalex.org/W2120151544","https://openalex.org/W2123719970","https://openalex.org/W2152169043","https://openalex.org/W2179053277","https://openalex.org/W2407567905","https://openalex.org/W2460658447"],"related_works":["https://openalex.org/W2019628696","https://openalex.org/W2093806586","https://openalex.org/W1978979365","https://openalex.org/W2014216626","https://openalex.org/W1843770684","https://openalex.org/W1607461883","https://openalex.org/W1980495472","https://openalex.org/W2418328860","https://openalex.org/W2151751706","https://openalex.org/W2077740541"],"abstract_inverted_index":{"To":[0],"better":[1],"define":[2],"the":[3,11,17,43,50,81,96,102,107,121],"mechanisms":[4],"by":[5,41,106,160],"which":[6,47],"viruses":[7],"depress":[8,148],"immune":[9],"function,":[10],"effect":[12],"of":[13,19,25,45,59,71,83,128,139],"influenza":[14,64,135,145],"infection":[15,109,146],"on":[16],"ability":[18,151],"macrophages":[20,131,154],"to":[21,80,152,155],"accumulate":[22],"at":[23],"sites":[24,157],"inflammation":[26],"was":[27,104,137],"determined.":[28],"Mice":[29,61],"were":[30],"inoculated":[31],"with":[32,63,133],"virus,":[33],"and":[34,68,74],"their":[35,162],"inflammatory":[36,118,156],"response":[37,82],"measured":[38],"in":[39,49,95,120,124,158],"vivo":[40,159],"counting":[42],"number":[44],"leukocytes":[46],"accumulated":[48],"peritoneal":[51,130],"cavity":[52],"2":[53],"days":[54],"after":[55],"an":[56],"intraperitoneal":[57],"injection":[58],"phytohemagglutinin.":[60],"infected":[62],"had":[65],"a":[66,93,113,149],"57%":[67],"65%":[69],"depression":[70,103],"total":[72],"leukocyte":[73],"macrophage":[75,97],"accumulation,":[76],"respectively,":[77],"as":[78],"compared":[79],"uninfected":[84],"mice.":[85],"In":[86],"contrast,":[87],"bacterial":[88],"pneumonia":[89],"did":[90],"not":[91],"produce":[92],"decrease":[94],"response.":[98],"This":[99],"indicated":[100],"that":[101,144],"produced":[105],"virus":[108,136],"rather":[110],"than":[111],"being":[112],"nonspecific":[114],"phenomenon":[115],"accompanying":[116],"any":[117],"focus":[119],"lung.":[122],"The":[123],"vitro":[125],"chemotactic":[126,163],"responsiveness":[127],"normal":[129],"incubated":[132],"infectious":[134],"53%":[138],"normal.":[140],"These":[141],"experiments":[142],"suggest":[143],"may":[147],"host's":[150],"mobilize":[153],"inhibiting":[161],"responsiveness.":[164]},"counts_by_year":[{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}