{"id":"https://openalex.org/W145182000","doi":null,"title":"[Metastatic hormone refractory prostate cancer: new treatment horizon].","display_name":"[Metastatic hormone refractory prostate cancer: new treatment horizon].","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W145182000","mag":"145182000","pmid":"https://pubmed.ncbi.nlm.nih.gov/23367751"},"language":"en","primary_location":{"id":"pmid:23367751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23367751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Harefuah","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049181473","display_name":"Daniel Keizman","orcid":"https://orcid.org/0000-0002-1087-1147","observed_orcids":["https://orcid.org/0000-0002-1087-1147"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2801839060","display_name":"Meir Medical Center","ror":"https://ror.org/04pc7j325","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801839060"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniel Keizman","raw_affiliation_strings":["Genitourinary Oncology Service, Division of Oncology, Meir Medical Center, Sackler Faculty of Medicine, Tel Aviv University. danielkeizman@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genitourinary Oncology Service, Division of Oncology, Meir Medical Center, Sackler Faculty of Medicine, Tel Aviv University. danielkeizman@gmail.com","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2801839060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111523918","display_name":"Natalie Maimon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalie Maimon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039952118","display_name":"Maya Gottfried","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maya Gottfried","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1031,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47460733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"151","issue":"9","first_page":"545","last_page":"9, 555, 554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.925000011920929},{"id":"https://openalex.org/keywords/sipuleucel-t","display_name":"sipuleucel-T","score":0.9020000100135803},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cabazitaxel","display_name":"cabazitaxel","score":0.9900000095367432},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9929999709129333},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9129999876022339},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.781000018119812},{"id":"https://openalex.org/keywords/cyp17-inhibitors","display_name":"CYP17 inhibitors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/taxane-based-chemotherapy","display_name":"taxane-based chemotherapy","score":0.703000009059906},{"id":"https://openalex.org/keywords/bone-targeted-therapy","display_name":"bone-targeted therapy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/skeletal-related-events","display_name":"skeletal-related events","score":0.9240000247955322},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.45500001311302185},{"id":"https://openalex.org/keywords/survival-benefit","display_name":"survival benefit","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9211175441741943},{"id":"https://openalex.org/C2778971682","wikidata":"https://www.wikidata.org/wiki/Q412963","display_name":"Cabazitaxel","level":5,"score":0.8472193479537964},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7898099422454834},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.6967195272445679},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6633391380310059},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.649013102054596},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.635037899017334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5385796427726746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5255478620529175},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.45422959327697754},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4423200786113739},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.41236260533332825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33084309101104736},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.2038215696811676},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.15593799948692322},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.07624086737632751}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23367751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23367751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Harefuah","raw_type":"English Abstract"},{"id":"mag:145182000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23367751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066791931","https://openalex.org/W2040607554","https://openalex.org/W2418625513","https://openalex.org/W1972763326","https://openalex.org/W2465205823","https://openalex.org/W2062540768","https://openalex.org/W2015582258","https://openalex.org/W1991931333","https://openalex.org/W1974901837","https://openalex.org/W1839957286"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,8,25,57],"is":[2],"the":[3,13,22,36,64,105,111,119,135,147,160],"second":[4],"leading":[5],"cause":[6],"of":[7,24,55,66,77,91,149],"death":[9],"in":[10,12,59,102,146,159,164],"men":[11],"western":[14],"world.":[15],"Most":[16],"deaths":[17],"will":[18,154],"occur":[19],"due":[20],"to":[21,41,63,95],"progression":[23],"into":[26],"a":[27,99,144],"hormone":[28,48],"refractory":[29,49],"state.":[30],"Until":[31],"recently,":[32],"docetaxel-based":[33],"chemotherapy":[34],"was":[35,130],"only":[37],"established":[38],"treatment":[39,78],"(shown":[40],"increase":[42],"survival)":[43],"for":[44,80,137],"patients":[45,138],"with":[46,88,98,139],"metastatic":[47],"prostate":[50,56],"cancer.":[51],"The":[52],"improved":[53],"understanding":[54],"biology":[58],"recent":[60,157],"years":[61],"led":[62],"development":[65],"drugs":[67],"directed":[68],"against":[69],"precise":[70],"tumorigenesis-associated":[71],"molecular":[72],"pathways,":[73],"and":[74,118],"significant":[75],"expansion":[76],"horizons":[79],"these":[81],"patients.":[82],"In":[83],"2010-2011,":[84],"three":[85],"more":[86],"agents,":[87],"different":[89],"mechanisms":[90],"action,":[92],"were":[93],"shown":[94],"be":[96],"associated":[97],"survival":[100],"benefit":[101],"mHRPC,":[103],"including":[104],"dendritic":[106],"cell":[107],"vaccine":[108],"sipuleucel-T":[109],"(immunotherapy),":[110],"17,20":[112],"lyase":[113],"inhibitor":[114],"abiraterone":[115],"(hormonal":[116],"therapy),":[117],"taxane":[120],"cabazitaxel":[121],"(chemotherapy).":[122],"A":[123],"fourth":[124],"agent,":[125],"denosumab":[126],"(bone":[127],"targeted":[128],"therapy)":[129],"also":[131],"recently":[132],"approved":[133],"by":[134],"FDA":[136],"bone":[140],"metastasis":[141],"after":[142],"showing":[143],"reduction":[145],"occurrence":[148],"skeletal-related":[150],"events.":[151],"This":[152],"review":[153],"focus":[155],"on":[156],"advances":[158],"standard":[161],"treatments":[162],"paradigm":[163],"mHRPC.":[165]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
