{"id":"https://openalex.org/W145081982","doi":null,"title":"Evidence of long-term survival of donor-derived cells after limbal allograft transplantation.","display_name":"Evidence of long-term survival of donor-derived cells after limbal allograft transplantation.","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W145081982","mag":"145081982","pmid":"https://pubmed.ncbi.nlm.nih.gov/10393033"},"language":"en","primary_location":{"id":"pmid:10393033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10393033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053794454","display_name":"Jun Shimazaki","orcid":"https://orcid.org/0000-0002-0435-3095","observed_orcids":["https://orcid.org/0000-0002-0435-3095"]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Shimazaki","raw_affiliation_strings":["Department of Ophthalmology, Tokyo Dental College, Chiba, Ichikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Tokyo Dental College, Chiba, Ichikawa, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028793041","display_name":"Minako Kaido","orcid":"https://orcid.org/0000-0001-5604-5847","observed_orcids":["https://orcid.org/0000-0001-5604-5847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kaido","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113802362","display_name":"Naoshi Shinozaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Shinozaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023859247","display_name":"Shigeto Shimmura","orcid":"https://orcid.org/0000-0002-0992-4862","observed_orcids":["https://orcid.org/0000-0002-0992-4862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Shimmura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034486405","display_name":"Batmunkh Munkhbat","orcid":"https://orcid.org/0000-0002-8664-7483","observed_orcids":["https://orcid.org/0000-0002-8664-7483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Munkhbat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028277227","display_name":"Masao Hagihara","orcid":"https://orcid.org/0000-0002-7143-4813","observed_orcids":["https://orcid.org/0000-0002-7143-4813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Hagihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049464528","display_name":"Kazuhide Tsuji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tsuji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000405522","display_name":"Kazuo Tsubota","orcid":"https://orcid.org/0000-0002-8874-7111","observed_orcids":["https://orcid.org/0000-0002-8874-7111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tsubota","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3016,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.90751063,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"40","issue":"8","first_page":"1664","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donor-derived-cells","display_name":"donor-derived cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/corneal-epithelium","display_name":"corneal epithelium","score":0.8619999885559082},{"id":"https://openalex.org/keywords/penetrating-keratoplasty","display_name":"penetrating keratoplasty","score":0.8849999904632568},{"id":"https://openalex.org/keywords/limbal-stem-cells","display_name":"limbal stem cells","score":0.734000027179718},{"id":"https://openalex.org/keywords/hla-dpb1","display_name":"HLA-DPB1","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6959419846534729},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.6268418431282043},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.6172839403152466},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.6100460886955261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5984595417976379},{"id":"https://openalex.org/C2780686511","wikidata":"https://www.wikidata.org/wiki/Q579361","display_name":"Corneal transplantation","level":3,"score":0.5823734402656555},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.5159459710121155},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.45799049735069275},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.44825148582458496},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.4370136260986328},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41844555735588074},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4182620048522949},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3259015381336212},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.2634217143058777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2487700879573822},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.22604534029960632},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21252155303955078},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15504184365272522},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09079745411872864},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07927080988883972}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003316","descriptor_name":"Corneal Diseases","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006682","descriptor_name":"HLA-DP Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014019","descriptor_name":"Tissue Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014960","descriptor_name":"X Chromosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014998","descriptor_name":"Y Chromosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015948","descriptor_name":"Keratoplasty, Penetrating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016850","descriptor_name":"Limbus Corneae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059868","descriptor_name":"HLA-DP beta-Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10393033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10393033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:145081982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10393033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W161732618","https://openalex.org/W164798711","https://openalex.org/W1528351551","https://openalex.org/W1964228231","https://openalex.org/W1987330130","https://openalex.org/W1990686172","https://openalex.org/W1992371645","https://openalex.org/W2009846860","https://openalex.org/W2023098878","https://openalex.org/W2023468388","https://openalex.org/W2063639875","https://openalex.org/W2092636293","https://openalex.org/W2119226652","https://openalex.org/W2128078747","https://openalex.org/W2132243512"],"related_works":["https://openalex.org/W2007513704","https://openalex.org/W2074847128","https://openalex.org/W2369537188","https://openalex.org/W2059434145","https://openalex.org/W2023098878","https://openalex.org/W4327676744","https://openalex.org/W2117412497","https://openalex.org/W4234564665","https://openalex.org/W2042831405","https://openalex.org/W2100455312"],"abstract_inverted_index":{"PURPOSE:":[0],"Severe":[1],"destruction":[2],"of":[3,24,37,127,138,171,180,216],"the":[4,22,29,38,60,98,107,132,143,154,172,175,185,217],"corneal":[5,39,49,218],"limbus":[6],"causes":[7],"conjunctival":[8],"invasion":[9],"and":[10,77,88,101,135,150,156,163,178,207],"subsequent":[11],"visual":[12],"loss.":[13],"Limbal":[14],"allograft":[15],"transplantation":[16,36,215],"(LAT)":[17],"was":[18],"recently":[19],"proposed":[20],"for":[21],"treatment":[23],"these":[25,147],"disorders.":[26],"However,":[27],"whether":[28],"method":[30],"functions":[31],"as":[32,117,212],"a":[33],"stem":[34,213],"cell":[35,214],"epithelium":[40],"remains":[41],"unclear.":[42],"This":[43],"study":[44],"provided":[45],"evidence":[46],"that":[47,195,208],"donor-derived":[48,189,196],"epithelial":[50,121],"cells":[51,58,122,197],"survive":[52,198],"long":[53],"after":[54,201,205],"LAT.":[55],"METHODS:":[56],"Epithelial":[57],"on":[59],"paracentral":[61],"cornea":[62],"in":[63,73,97,106,125,131,136,142,153,174,184],"patients":[64],"who":[65],"have":[66],"undergone":[67],"LAT":[68,202,209],"were":[69,91,104,123],"subjected":[70],"to":[71],"fluorescence":[72],"situ":[74],"hybridization":[75],"(FISH)":[76],"polymerase":[78],"chain":[79],"reaction":[80],"restriction":[81],"fragment":[82],"length":[83],"polymorphism":[84],"(RFLP)":[85],"analysis.":[86,109,145],"X":[87],"Y":[89],"chromosomes":[90],"detected":[92,124],"using":[93],"sex":[94],"chromosome-specific":[95],"probes":[96],"FISH":[99,133,155,176],"analysis,":[100,158],"HLA-DPBI":[102],"antigens":[103],"examined":[105],"RFLP":[108,144,157,186],"Eyes":[110],"receiving":[111],"conventional":[112],"penetrating":[113],"keratoplasty":[114],"(PKP)":[115],"served":[116],"controls.":[118],"RESULTS:":[119],"Donor-derived":[120],"three":[126,151],"five":[128],"eyes":[129,140,152,173,182],"(60.0%)":[130],"analysis":[134,177,187],"seven":[137],"nine":[139],"(77.8%)":[141],"Among":[146],"eyes,":[148,169],"one":[149,179],"respectively,":[159],"had":[160,188],"both":[161],"donor-":[162],"recipient-derived":[164],"cells.":[165,190],"In":[166],"control":[167],"PKP":[168],"none":[170],"eight":[181],"(12.5%)":[183],"CONCLUSIONS:":[191],"These":[192],"results":[193],"suggest":[194],"much":[199],"longer":[200],"than":[203],"those":[204],"PKP,":[206],"may":[210],"function":[211],"epithelium.":[219]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}