{"id":"https://openalex.org/W145040693","doi":null,"title":"Segregation of Protein Synthesis Between the Cytoplasm and Endoplasmic Reticulum of Eukaryotic Cells","display_name":"Segregation of Protein Synthesis Between the Cytoplasm and Endoplasmic Reticulum of Eukaryotic Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W145040693","mag":"145040693"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/8752","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/8752","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"David W. Reid","orcid":"https://orcid.org/0000-0001-9517-8212","observed_orcids":["https://orcid.org/0000-0001-9517-8212"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David W. Reid","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9517-8212","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.800000011920929},{"id":"https://openalex.org/keywords/cytoplasmic-translation","display_name":"cytoplasmic translation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/ribosome-profiling","display_name":"ribosome profiling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ribosome-localization","display_name":"ribosome localization","score":0.5270000100135803},{"id":"https://openalex.org/keywords/membrane-bound-ribosomes","display_name":"membrane-bound ribosomes","score":0.5979999899864197},{"id":"https://openalex.org/keywords/mrna-localization","display_name":"mRNA localization","score":0.47099998593330383},{"id":"https://openalex.org/keywords/cellular-stress","display_name":"cellular stress","score":0.6919999718666077},{"id":"https://openalex.org/keywords/eukaryotic-translation","display_name":"eukaryotic translation","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.9161229133605957},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.740149974822998},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.646896243095398},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33969563245773315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3256776034832001}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/8752","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/8752","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:145040693","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/handle/10161/8752","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W10583676","https://openalex.org/W92706563","https://openalex.org/W1480017877","https://openalex.org/W1496711114","https://openalex.org/W1513707980","https://openalex.org/W1544032942","https://openalex.org/W1549105044","https://openalex.org/W1782800388","https://openalex.org/W1799375255","https://openalex.org/W1970827552","https://openalex.org/W1971447046","https://openalex.org/W1975567952","https://openalex.org/W1977603207","https://openalex.org/W1980600234","https://openalex.org/W1981503496","https://openalex.org/W1989616670","https://openalex.org/W1990136127","https://openalex.org/W1998455720","https://openalex.org/W2001089030","https://openalex.org/W2001139514","https://openalex.org/W2001783477","https://openalex.org/W2002404925","https://openalex.org/W2004415810","https://openalex.org/W2006755949","https://openalex.org/W2013624095","https://openalex.org/W2014601071","https://openalex.org/W2016417523","https://openalex.org/W2016983085","https://openalex.org/W2018903948","https://openalex.org/W2019277035","https://openalex.org/W2019537934","https://openalex.org/W2020564484","https://openalex.org/W2021578350","https://openalex.org/W2021583109","https://openalex.org/W2024754727","https://openalex.org/W2028991871","https://openalex.org/W2033509582","https://openalex.org/W2035621280","https://openalex.org/W2036379239","https://openalex.org/W2040119910","https://openalex.org/W2040232267","https://openalex.org/W2041154872","https://openalex.org/W2048423346","https://openalex.org/W2048551040","https://openalex.org/W2050669001","https://openalex.org/W2051250838","https://openalex.org/W2051293392","https://openalex.org/W2057493648","https://openalex.org/W2058468920","https://openalex.org/W2059646461","https://openalex.org/W2061313445","https://openalex.org/W2068417373","https://openalex.org/W2070969331","https://openalex.org/W2070983121","https://openalex.org/W2071849521","https://openalex.org/W2072736486","https://openalex.org/W2076131270","https://openalex.org/W2079517684","https://openalex.org/W2080666240","https://openalex.org/W2080669995","https://openalex.org/W2083113334","https://openalex.org/W2083323375","https://openalex.org/W2083408202","https://openalex.org/W2084940540","https://openalex.org/W2088536925","https://openalex.org/W2095701936","https://openalex.org/W2099923841","https://openalex.org/W2099951367","https://openalex.org/W2101072770","https://openalex.org/W2102201203","https://openalex.org/W2103356759","https://openalex.org/W2107903949","https://openalex.org/W2108708484","https://openalex.org/W2109218888","https://openalex.org/W2110420807","https://openalex.org/W2112795272","https://openalex.org/W2113896518","https://openalex.org/W2119575179","https://openalex.org/W2120736516","https://openalex.org/W2123719726","https://openalex.org/W2124911939","https://openalex.org/W2124985265","https://openalex.org/W2127233686","https://openalex.org/W2127387423","https://openalex.org/W2128207929","https://openalex.org/W2129178024","https://openalex.org/W2130165454","https://openalex.org/W2130816124","https://openalex.org/W2131756959","https://openalex.org/W2133968430","https://openalex.org/W2134257152","https://openalex.org/W2141030634","https://openalex.org/W2143991789","https://openalex.org/W2146873025","https://openalex.org/W2146923243","https://openalex.org/W2151025890","https://openalex.org/W2152770371","https://openalex.org/W2154119088","https://openalex.org/W2154421140","https://openalex.org/W2155163967","https://openalex.org/W2156777696","https://openalex.org/W2156990953","https://openalex.org/W2157561719","https://openalex.org/W2159687484","https://openalex.org/W2159807777","https://openalex.org/W2161746138","https://openalex.org/W2163482144","https://openalex.org/W2171323620","https://openalex.org/W2283642928","https://openalex.org/W2530346991"],"related_works":["https://openalex.org/W2083323375","https://openalex.org/W1987651105","https://openalex.org/W2134257152","https://openalex.org/W2023261130","https://openalex.org/W3118004195","https://openalex.org/W3173774535","https://openalex.org/W92706563","https://openalex.org/W10583676","https://openalex.org/W2127387423","https://openalex.org/W2253224822"],"abstract_inverted_index":{"The":[0,28,123],"partitioning":[1],"of":[2,8,20,25,46,49,55,68,80,101,107,150,164,177],"translation":[3,165,178],"to":[4,31,36,39,43,87,114],"the":[5,9,18,23,26,40,53,62,66,105,157,162,175],"outer":[6],"membrane":[7,41],"endoplasmic":[10,63,158],"reticulum":[11,159],"is":[12,104,128,132,153],"a":[13,47,147],"problem":[14],"that":[15,58,69,94,117],"has":[16],"been":[17,96,120],"subject":[19],"inquiry":[21],"since":[22],"discovery":[24],"ribosome.":[27],"large":[29],"degree":[30],"which":[32,131],"ribosomes":[33],"were":[34],"found":[35],"be":[37],"tethered":[38],"led":[42],"intense":[44],"investigation":[45],"series":[48],"related":[50],"questions":[51,82],"regarding":[52],"identity":[54],"those":[56,92],"mRNAs":[57,152],"are":[59],"translated":[60],"on":[61,156],"reticulum,":[64],"and":[65,85,137,170,173],"functions":[67],"localization":[70],"in":[71,83,185],"cell":[72,138,186],"stress.":[73,187],"In":[74],"this":[75,102],"dissertation,":[76],"I":[77,141],"approach":[78],"each":[79],"these":[81],"turn":[84],"work":[86,103],"reconcile":[88],"my":[89],"observations":[90],"with":[91,134],"models":[93],"have":[95],"previously":[97],"proposed.":[98],"A":[99],"theme":[100],"application":[106],"modern":[108],"methods,":[109],"particularly":[110],"deep":[111],"sequencing":[112],"technology,":[113],"address":[115],"problems":[116],"had":[118],"largely":[119],"considered":[121],"solved.":[122],"most":[124],"prominently":[125],"featured":[126],"method":[127],"ribosome":[129],"profiling,":[130],"paired":[133],"classical":[135],"biochemical":[136],"biological":[139],"techniques.":[140],"arrive":[142],"at":[143],"several":[144],"conclusions:":[145],"1)":[146],"significant":[148],"fraction":[149],"all":[151],"well":[154],"represented":[155],"membrane,":[160],"2)":[161],"properties":[163],"diverge":[166],"substantially":[167],"between":[168],"membrane-associated":[169],"free":[171],"ribosomes,":[172],"3)":[174],"compartmentalization":[176],"can":[179],"serve":[180],"as":[181],"an":[182],"important":[183],"variable":[184]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}