{"id":"https://openalex.org/W144246778","doi":null,"title":"The molecular basis of microtubule stability in neurons.","display_name":"The molecular basis of microtubule stability in neurons.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W144246778","mag":"144246778","pmid":"https://pubmed.ncbi.nlm.nih.gov/8090350"},"language":"en","primary_location":{"id":"pmid:8090350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8090350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017788436","display_name":"Marcia M. Falconer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1331897569","display_name":"Agriculture and Agri-Food Canada","ror":"https://ror.org/051dzs374","country_code":"CA","type":"government","lineage":["https://openalex.org/I1331897569","https://openalex.org/I2802286613"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M M Falconer","raw_affiliation_strings":["Agriculture Canada, Ottawa, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agriculture Canada, Ottawa, Ontario","institution_ids":["https://openalex.org/I1331897569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026252641","display_name":"Andrew Vaillant","orcid":"https://orcid.org/0000-0002-1433-0700","observed_orcids":["https://orcid.org/0000-0002-1433-0700"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Vaillant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039403500","display_name":"Kenneth R. Reuhl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K R Reuhl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050487413","display_name":"Nicole Laferriere","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Laferri\u00e8re","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103443853","display_name":"David L. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D L Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5468,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.57649859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"109","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule-stability","display_name":"microtubule stability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.859000027179718},{"id":"https://openalex.org/keywords/tubulin-isotypes","display_name":"tubulin isoforms","score":0.8740000128746033},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/p19-cells","display_name":"P19 cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.8450000286102295},{"id":"https://openalex.org/keywords/methylmercury","display_name":"methylmercury","score":0.8899999856948853},{"id":"https://openalex.org/keywords/microtubule-associated-proteins","display_name":"microtubule-associated proteins","score":0.8180000185966492},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.8651894330978394},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7932514548301697},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.6320807933807373},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5902764797210693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5720731616020203},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5604845285415649},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5356627702713013},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4706506133079529},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4105850160121918},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37701302766799927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35975176095962524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.316588819026947},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1720014214515686},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8090350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8090350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotoxicology","raw_type":"Journal Article"},{"id":"mag:144246778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8090350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6616322159","display_name":"MECHANISMS OF MEHG NEUROTOXICITY DURING DEVELOPMENT","funder_award_id":"R01ES004976","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605912089","https://openalex.org/W2090565067","https://openalex.org/W1976822259","https://openalex.org/W2789795697","https://openalex.org/W2051861508","https://openalex.org/W6907389937","https://openalex.org/W1816087024","https://openalex.org/W2276736055","https://openalex.org/W2075750800","https://openalex.org/W1961241899"],"abstract_inverted_index":{"Microtubule":[0],"(Mt)":[1],"populations":[2],"show":[3,125],"large":[4],"differences":[5,34],"in":[6,35,70,74,114,133],"dynamic":[7,36],"properties":[8,37],"(i.e.,":[9],"turnover":[10],"rates)":[11],"among":[12],"cell":[13,20,27,95],"types,":[14],"and":[15,56,68,80,154],"even":[16],"within":[17],"the":[18,26,52,91,104,118,134,140,148],"same":[19],"type":[21],"at":[22],"different":[23],"stages":[24,30],"of":[25,31,120,136,150,159],"cycle":[28],"or":[29],"differentiation.":[32,87],"These":[33],"are":[38,89],"correlated":[39],"with":[40,64],"altered":[41],"sensitivity":[42],"to":[43,51,57,83,101,116,147,155],"Mt-disassembling":[44],"drugs":[45],"(e.g.":[46,66],"colchicine)":[47],"which":[48,61,97,115],"bind":[49],"specifically":[50],"Mt":[53,71],"protein":[54],"tubulin":[55,65,137],"certain":[58],"toxic":[59],"metals":[60],"also":[62],"interact":[63],"methylmercury)":[67],"result":[69],"disassembly.":[72],"Mts":[73],"neurons":[75],"become":[76],"progressively":[77],"more":[78,81],"stable":[79,121,141],"resistant":[82],"such":[84],"compounds":[85],"during":[86,127],"We":[88],"using":[90],"P19":[92],"embryonal":[93],"carcinoma":[94],"line,":[96],"can":[98],"be":[99],"induced":[100],"differentiate":[102],"along":[103],"neural":[105],"pathway":[106],"by":[107],"retinoic":[108],"acid,":[109],"as":[110],"a":[111],"model":[112],"system":[113],"analyze":[117],"development":[119],"Mts.":[122,142],"Our":[123],"results":[124],"that":[126],"differentiation":[128],"there":[129],"is":[130],"an":[131],"evolution":[132],"sorting":[135],"isotypes":[138],"into":[139],"This":[143],"appears":[144],"related":[145],"both":[146],"expression":[149],"specific":[151],"Mt-associated":[152],"proteins":[153],"concomitant":[156],"posttranslational":[157],"modifications":[158],"tubulin.":[160]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
