{"id":"https://openalex.org/W144189276","doi":null,"title":"Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments","display_name":"Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W144189276","mag":"144189276"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-8719","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8719","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8719","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022266207","display_name":"Petra Jauslin-Stetina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Petra Jauslin-Stetina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022266207"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.19859999418258667,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.09690000116825104,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-insulin-regulation","display_name":"glucose-insulin regulation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/mechanistic-modeling","display_name":"mechanistic modeling","score":0.675000011920929},{"id":"https://openalex.org/keywords/glucose-insulin-system","display_name":"glucose-insulin system","score":0.5299999713897705},{"id":"https://openalex.org/keywords/oral-glucose-tolerance-test","display_name":"oral glucose tolerance test","score":0.7900000214576721},{"id":"https://openalex.org/keywords/intravenous-glucose-tolerance-test","display_name":"intravenous glucose tolerance test","score":0.9480000138282776},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7129999995231628},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.925000011920929},{"id":"https://openalex.org/keywords/incretin-hormones","display_name":"incretins","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glucokinase-activators","display_name":"glucokinase activators","score":0.9049999713897705},{"id":"https://openalex.org/keywords/oral-antidiabetic-drugs","display_name":"oral antidiabetic drugs","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nonmem","display_name":"NONMEM","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C110586980","wikidata":"https://www.wikidata.org/wiki/Q4168588","display_name":"Provocation test","level":3,"score":0.8049592971801758},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6324409246444702},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5817958116531372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42032909393310547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30775123834609985},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.08136102557182312},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0663692057132721},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-8719","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8719","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:144189276","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:172014/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-8719","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8719","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":105,"referenced_works":["https://openalex.org/W9702823","https://openalex.org/W82332366","https://openalex.org/W219509547","https://openalex.org/W1492642476","https://openalex.org/W1495821788","https://openalex.org/W1499836849","https://openalex.org/W1535918788","https://openalex.org/W1600205228","https://openalex.org/W1844237527","https://openalex.org/W1964594353","https://openalex.org/W1965479467","https://openalex.org/W1968676703","https://openalex.org/W1969550954","https://openalex.org/W1974127796","https://openalex.org/W1975007709","https://openalex.org/W1978691530","https://openalex.org/W1979251485","https://openalex.org/W1985214082","https://openalex.org/W1995856733","https://openalex.org/W1998796882","https://openalex.org/W2002062638","https://openalex.org/W2002510399","https://openalex.org/W2003423742","https://openalex.org/W2004332450","https://openalex.org/W2005069607","https://openalex.org/W2008777316","https://openalex.org/W2012613359","https://openalex.org/W2014825234","https://openalex.org/W2020212606","https://openalex.org/W2021088264","https://openalex.org/W2025050665","https://openalex.org/W2027219674","https://openalex.org/W2027651218","https://openalex.org/W2028212562","https://openalex.org/W2033125833","https://openalex.org/W2035586426","https://openalex.org/W2037815969","https://openalex.org/W2038856804","https://openalex.org/W2043131921","https://openalex.org/W2046692300","https://openalex.org/W2046913994","https://openalex.org/W2047922146","https://openalex.org/W2051148993","https://openalex.org/W2051313176","https://openalex.org/W2058734479","https://openalex.org/W2059158127","https://openalex.org/W2059185356","https://openalex.org/W2064503593","https://openalex.org/W2066464642","https://openalex.org/W2071157269","https://openalex.org/W2071379680","https://openalex.org/W2071889852","https://openalex.org/W2073909589","https://openalex.org/W2074648492","https://openalex.org/W2075404533","https://openalex.org/W2077925769","https://openalex.org/W2087036494","https://openalex.org/W2088901347","https://openalex.org/W2090179984","https://openalex.org/W2090609048","https://openalex.org/W2091458190","https://openalex.org/W2095712584","https://openalex.org/W2096971852","https://openalex.org/W2100588873","https://openalex.org/W2100629874","https://openalex.org/W2101766292","https://openalex.org/W2103358437","https://openalex.org/W2105912552","https://openalex.org/W2106492305","https://openalex.org/W2108596481","https://openalex.org/W2113637996","https://openalex.org/W2116828634","https://openalex.org/W2116990096","https://openalex.org/W2120162658","https://openalex.org/W2123767112","https://openalex.org/W2125624587","https://openalex.org/W2126592113","https://openalex.org/W2127277443","https://openalex.org/W2127903745","https://openalex.org/W2132549450","https://openalex.org/W2135349217","https://openalex.org/W2137279136","https://openalex.org/W2138487775","https://openalex.org/W2145434855","https://openalex.org/W2145650362","https://openalex.org/W2151588256","https://openalex.org/W2151729293","https://openalex.org/W2151984197","https://openalex.org/W2157712434","https://openalex.org/W2164933519","https://openalex.org/W2168636299","https://openalex.org/W2168853799","https://openalex.org/W2169675402","https://openalex.org/W2174384846","https://openalex.org/W2174569309","https://openalex.org/W2181947976","https://openalex.org/W2271842395","https://openalex.org/W2300639120","https://openalex.org/W2324227497","https://openalex.org/W2337388618","https://openalex.org/W2344994915","https://openalex.org/W2345903479","https://openalex.org/W2410760324","https://openalex.org/W2413926957","https://openalex.org/W2437708936"],"related_works":["https://openalex.org/W171771894","https://openalex.org/W2096550268","https://openalex.org/W1970607508","https://openalex.org/W39089956","https://openalex.org/W3047335323","https://openalex.org/W2104978215","https://openalex.org/W2137616878","https://openalex.org/W2040770427","https://openalex.org/W2032261734","https://openalex.org/W7102767473"],"abstract_inverted_index":{"Type":[0],"2":[1,218],"diabetes":[2],"is":[3,46,53,79,85,102,181],"a":[4,14,21,91,112,182,186,246,249,266,271],"complex":[5,187],"chronic":[6],"metabolic":[7],"disorder":[8],"characterized":[9],"by":[10,168,202],"hyperglycemia":[11],"associated":[12],"with":[13],"relative":[15],"deficiency":[16],"of":[17,24,37,72,115,138,155,165,185,197,223,229,235,243,245,268,270,285],"insulin":[18,59,109,145,158,208,211,236],"secretion":[19,209,237],"and":[20,108,122,129,144,160,210,216,238,259],"reduced":[22],"response":[23],"target":[25],"tissues":[26],"to":[27,65,87,104,192],"insulin.":[28],"Considerable":[29],"efforts":[30],"have":[31],"been":[32],"put":[33],"into":[34],"the":[35,40,66,83,153,194,205,221,232,240,257,260,282],"development":[36,284],"models":[38],"describing":[39],"glucose-insulin":[41,96],"system.":[42],"The":[43,94],"best":[44],"known":[45],"Bergman\u2019s":[47],"\u201cminimal\u201d":[48],"model":[49,84,97,180,274],"for":[50,140,152],"glucose,":[51,141,230],"which":[52],"estimating":[54],"glucose":[55,107,124,143,156,161],"concentrations":[56,60],"using":[57],"fixed":[58],"as":[61,90,120],"input.":[62],"However,":[63],"due":[64],"involved":[67],"feedback":[68],"mechanisms,":[69],"simultaneous":[70],"modeling":[71,172],"both":[73,256],"entities":[74],"would":[75],"be":[76,88],"advantageous.":[77],"This":[78],"particularly":[80],"relevant":[81],"if":[82,178],"intended":[86],"used":[89],"predictive":[92],"tool.":[93],"mechanism-based":[95],"presented":[98],"in":[99,175,207,281],"this":[100,179,198],"thesis":[101],"able":[103],"simultaneously":[105],"describe":[106],"profiles":[110],"following":[111],"wide":[113],"variety":[114],"clinical":[116,283],"provocation":[117],"experiments,":[118],"such":[119],"intravenous":[121],"oral":[123,227,251],"tolerance":[125],"tests,":[126],"clamp":[127],"studies":[128],"sequential":[130],"meal":[131],"tests":[132],"over":[133],"24":[134],"hours.":[135],"It":[136,147],"consists":[137],"sub-models":[139],"labeled":[142],"kinetics.":[146],"also":[148],"incorporates":[149],"control":[150],"mechanisms":[151],"regulation":[154],"production,":[157],"secretion,":[159],"uptake.":[162],"Simultaneous":[163],"analysis":[164],"all":[166],"data":[167],"nonlinear":[169],"mixed":[170],"effect":[171],"was":[173,200],"performed":[174],"NONMEM.":[176],"Even":[177],"crude":[183],"representation":[184],"physiological":[188],"system,":[189],"its":[190],"ability":[191],"represent":[193,265],"main":[195],"processes":[196],"system":[199],"established":[201],"identifying:":[203],"1)":[204],"difference":[206],"sensitivity":[212],"between":[213],"healthy":[214],"volunteers":[215],"type":[217],"diabetics,":[219],"2)":[220],"action":[222,244],"incretin":[224],"hormones":[225],"after":[226],"administration":[228],"3)":[231],"circadian":[233],"variation":[234],"4)":[239],"correct":[241],"mechanism":[242],"glucokinase":[247],"activator,":[248],"new":[250],"antidiabetic":[252],"compound":[253],"acting":[254],"on":[255],"pancreas":[258],"liver.":[261],"These":[262],"promising":[263],"results":[264],"proof":[267],"concept":[269],"mechanistic":[272],"drug-disease":[273],"that":[275],"could":[276],"play":[277],"an":[278],"important":[279],"role":[280],"anti-diabetic":[286],"drugs.":[287]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2016-06-24T00:00:00"}
