{"id":"https://openalex.org/W143986674","doi":"https://doi.org/10.1007/978-1-59745-225-0_13","title":"Regional Chemotherapy of Primary and Metastatic Liver Tumors","display_name":"Regional Chemotherapy of Primary and Metastatic Liver Tumors","publication_year":2007,"publication_date":"2007-10-18","ids":{"openalex":"https://openalex.org/W143986674","doi":"https://doi.org/10.1007/978-1-59745-225-0_13","mag":"143986674"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-225-0_13","doi":"https://doi.org/10.1007/978-1-59745-225-0_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-225-0_13","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Drug Discovery and Development","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2488061846","display_name":"Regional Cancer Therapy"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021876372","display_name":"Rebecca Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Taylor","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143066","display_name":"James S. Tomlinson","orcid":"https://orcid.org/0000-0001-8299-8211","observed_orcids":["https://orcid.org/0000-0001-8299-8211"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Tomlinson","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069644669","display_name":"Nancy E. Kemeny","orcid":"https://orcid.org/0000-0002-0929-9542","observed_orcids":["https://orcid.org/0000-0002-0929-9542"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Kemeny","raw_affiliation_strings":["Department of Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York","Memorial Sloan- Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan- Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08485273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"199","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-arterial-infusion-chemotherapy","display_name":"hepatic arterial infusion chemotherapy","score":0.878000020980835},{"id":"https://openalex.org/keywords/regional-chemotherapy","display_name":"regional chemotherapy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/primary-liver-tumors","display_name":"primary liver tumors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/portal-vein","display_name":"portal vein","score":0.48399999737739563},{"id":"https://openalex.org/keywords/hepatic-drug-metabolism","display_name":"hepatic drug metabolism","score":0.7710000276565552},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.6079999804496765},{"id":"https://openalex.org/keywords/catheter-insertion","display_name":"catheter insertion","score":0.824999988079071},{"id":"https://openalex.org/keywords/infusion-regimen","display_name":"infusion regimen","score":0.9369999766349792},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7931896448135376},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6911255121231079},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5967553853988647},{"id":"https://openalex.org/C2778405590","wikidata":"https://www.wikidata.org/wiki/Q5731662","display_name":"Hepatic arterial infusion","level":4,"score":0.5033594965934753},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.4328416585922241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4282369017601013},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37898868322372437},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33921897411346436},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3232186436653137}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59745-225-0_13","doi":"https://doi.org/10.1007/978-1-59745-225-0_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-225-0_13","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Drug Discovery and Development","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9932000041007996,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":135,"referenced_works":["https://openalex.org/W17151634","https://openalex.org/W19092580","https://openalex.org/W21933366","https://openalex.org/W142265171","https://openalex.org/W156342834","https://openalex.org/W183811027","https://openalex.org/W635294079","https://openalex.org/W858711022","https://openalex.org/W1485041712","https://openalex.org/W1489195779","https://openalex.org/W1797303364","https://openalex.org/W1823144309","https://openalex.org/W1835268604","https://openalex.org/W1923481401","https://openalex.org/W1950108228","https://openalex.org/W1961040537","https://openalex.org/W1965609218","https://openalex.org/W1966703018","https://openalex.org/W1967973254","https://openalex.org/W1968007924","https://openalex.org/W1971508679","https://openalex.org/W1972877504","https://openalex.org/W1979423262","https://openalex.org/W1983806323","https://openalex.org/W1985524610","https://openalex.org/W1986421985","https://openalex.org/W1986924507","https://openalex.org/W1989175303","https://openalex.org/W1994096003","https://openalex.org/W1996869264","https://openalex.org/W1998204369","https://openalex.org/W1998670990","https://openalex.org/W2000180049","https://openalex.org/W2000841655","https://openalex.org/W2005019571","https://openalex.org/W2007615142","https://openalex.org/W2010880947","https://openalex.org/W2011206688","https://openalex.org/W2012661344","https://openalex.org/W2013791154","https://openalex.org/W2016575308","https://openalex.org/W2016726396","https://openalex.org/W2018329764","https://openalex.org/W2022838936","https://openalex.org/W2024082570","https://openalex.org/W2030001310","https://openalex.org/W2034355730","https://openalex.org/W2036509953","https://openalex.org/W2036581805","https://openalex.org/W2038770487","https://openalex.org/W2040660791","https://openalex.org/W2042471859","https://openalex.org/W2043731575","https://openalex.org/W2044224410","https://openalex.org/W2044489431","https://openalex.org/W2045378626","https://openalex.org/W2046815309","https://openalex.org/W2047768140","https://openalex.org/W2051224942","https://openalex.org/W2059100143","https://openalex.org/W2063306258","https://openalex.org/W2067482493","https://openalex.org/W2069853951","https://openalex.org/W2072817424","https://openalex.org/W2075715091","https://openalex.org/W2075962633","https://openalex.org/W2079190855","https://openalex.org/W2080831579","https://openalex.org/W2081355464","https://openalex.org/W2082489033","https://openalex.org/W2083803103","https://openalex.org/W2084470612","https://openalex.org/W2084550050","https://openalex.org/W2086756826","https://openalex.org/W2087923534","https://openalex.org/W2089859497","https://openalex.org/W2095889631","https://openalex.org/W2097829977","https://openalex.org/W2099712907","https://openalex.org/W2101738215","https://openalex.org/W2102731555","https://openalex.org/W2104614485","https://openalex.org/W2111001038","https://openalex.org/W2112781970","https://openalex.org/W2119559403","https://openalex.org/W2121368761","https://openalex.org/W2122364701","https://openalex.org/W2125892433","https://openalex.org/W2127335298","https://openalex.org/W2128447158","https://openalex.org/W2128813634","https://openalex.org/W2135289239","https://openalex.org/W2137870494","https://openalex.org/W2140910498","https://openalex.org/W2146598063","https://openalex.org/W2154009817","https://openalex.org/W2157865573","https://openalex.org/W2160535919","https://openalex.org/W2161959477","https://openalex.org/W2167676775","https://openalex.org/W2171680834","https://openalex.org/W2196675369","https://openalex.org/W2202530793","https://openalex.org/W2221252789","https://openalex.org/W2247639671","https://openalex.org/W2266363139","https://openalex.org/W2269945922","https://openalex.org/W2314927739","https://openalex.org/W2315776200","https://openalex.org/W2316178638","https://openalex.org/W2395053451","https://openalex.org/W2395179321","https://openalex.org/W2397993196","https://openalex.org/W2403732834","https://openalex.org/W2406170699","https://openalex.org/W2406895791","https://openalex.org/W2410220635","https://openalex.org/W2412349823","https://openalex.org/W2413561263","https://openalex.org/W2415121171","https://openalex.org/W2415150699","https://openalex.org/W2415290148","https://openalex.org/W2416818602","https://openalex.org/W2417865372","https://openalex.org/W2418968326","https://openalex.org/W2436624330","https://openalex.org/W2462665941","https://openalex.org/W2468837473","https://openalex.org/W2477902440","https://openalex.org/W2601581313","https://openalex.org/W2602544133","https://openalex.org/W2604975714","https://openalex.org/W2727369339","https://openalex.org/W4232330952","https://openalex.org/W4237168178"],"related_works":["https://openalex.org/W1502131023","https://openalex.org/W1968007924","https://openalex.org/W2151459324","https://openalex.org/W2065565627","https://openalex.org/W1970668456","https://openalex.org/W2045078955","https://openalex.org/W3013719332","https://openalex.org/W2165461270","https://openalex.org/W3174962356","https://openalex.org/W2407474662"],"abstract_inverted_index":{"The":[0,87],"rationale":[1],"for":[2,205],"hepatic":[3,27,31,46,82,109,175,202,210],"arterial":[4,176,203],"infusion":[5,134,181,204],"of":[6,44,89,98,108,135,145,174,188,201,226],"chemotherapy":[7,50,73,122,136],"is":[8,128,163,223],"based":[9],"on":[10,34,215],"the":[11,26,35,42,45,96,104,112,125,160,168,184,196,224],"concept":[12],"that":[13],"most":[14,90,105,227],"primary":[15,79,207],"and":[16,80,171,183,186,199,208,229],"metastatic":[17,81],"liver":[18,154,216],"tumors":[19],"preferentially":[20],"derive":[21],"their":[22],"blood":[23,38],"supply":[24],"from":[25,218],"artery,":[28],"whereas":[29],"normal":[30],"tissue":[32],"relies":[33],"portal":[36],"venous":[37],"supply.":[39],"In":[40,149,191],"addition,":[41,192],"ability":[43],"parenchyma":[47],"to":[48,52,59,65,131,147],"metabolize":[49],"drugs":[51],"nontoxic":[53],"metabolites":[54],"offers":[55],"a":[56,142,213],"unique":[57,189],"opportunity":[58],"administer":[60],"highly":[61],"toxic":[62],"drug":[63],"levels":[64],"tumor":[66],"cells":[67],"while":[68],"minimizing":[69],"systemic":[70,120],"toxicity.":[71],"Regional":[72],"has":[74,93,123],"been":[75,94],"evaluated":[76],"in":[77,95,119],"both":[78],"malignancies":[83],"with":[84,115,141,212],"varying":[85],"results.":[86],"area":[88,225],"intensive":[91],"research":[92],"treatment":[97,187],"colorectal":[99,219],"cancer":[100],"because":[101],"it":[102,193],"represents":[103],"frequent":[106],"etiology":[107],"metastases.":[110],"Although":[111],"response":[113,139],"rate":[114],"newer":[116],"agents":[117],"used":[118],"combination":[121],"improved,":[124],"2-year":[126],"survival":[127,144,162],"only":[129],"25":[130],"39%.":[132],"Hepatic-arterial":[133],"produces":[137],"higher":[138],"rates,":[140],"2-yr":[143,161],"50":[146],"60%.":[148],"patients":[150],"who":[151],"can":[152],"undergo":[153],"resection":[155],"followed":[156],"by":[157],"hepatic-arterial":[158],"infusion,":[159,177],"85%.":[164],"This":[165],"chapter":[166],"summarizes":[167],"pharmacological":[169],"basis":[170],"technical":[172],"aspects":[173],"including":[178],"catheter":[179],"placement,":[180],"regimens,":[182],"development":[185],"toxicities.":[190],"will":[194],"review":[195],"current":[197],"evidence":[198],"role":[200],"all":[206],"secondary":[209],"malignancies,":[211],"focus":[214],"metastases":[217],"cancer,":[220],"as":[221],"this":[222],"experience":[228],"promise.":[230]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
