{"id":"https://openalex.org/W143825969","doi":null,"title":"Surfactant and Matrix Metalloproteinase 3 in the Pathogenesis of Acute Lung Injury","display_name":"Surfactant and Matrix Metalloproteinase 3 in the Pathogenesis of Acute Lung Injury","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W143825969","mag":"143825969"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-4169","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/2661","pdf_url":"https://ir.lib.uwo.ca/etd/2661","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.lib.uwo.ca/etd/2661","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073005566","display_name":"Valeria Puntorieri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Valeria Puntorieri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073005566"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00183531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.13760000467300415,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.9610000252723694},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-3","display_name":"matrix metalloproteinase-3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7256978154182434},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5506868958473206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49839162826538086},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.4780988395214081},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3223768174648285},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2955286502838135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2642897367477417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23247942328453064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08713066577911377}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-4169","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/2661","pdf_url":"https://ir.lib.uwo.ca/etd/2661","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.676.9790","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.676.9790","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ir.lib.uwo.ca/cgi/viewcontent.cgi?article%3D4169%26context%3Detd","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/35565","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/35565","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:143825969","doi":null,"is_oa":false,"landing_page_url":"http://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=4169&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-4169","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/2661","pdf_url":"https://ir.lib.uwo.ca/etd/2661","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W143825969.pdf","grobid_xml":"https://content.openalex.org/works/W143825969.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W48602920","https://openalex.org/W102298456","https://openalex.org/W1949707070","https://openalex.org/W1965751894","https://openalex.org/W1968069140","https://openalex.org/W1970293798","https://openalex.org/W1986193494","https://openalex.org/W1987825791","https://openalex.org/W1990922779","https://openalex.org/W1995403745","https://openalex.org/W1995509027","https://openalex.org/W1996925248","https://openalex.org/W2008308371","https://openalex.org/W2013929940","https://openalex.org/W2016869710","https://openalex.org/W2023082917","https://openalex.org/W2034248746","https://openalex.org/W2035579010","https://openalex.org/W2041445446","https://openalex.org/W2043829148","https://openalex.org/W2049849044","https://openalex.org/W2065850019","https://openalex.org/W2067991392","https://openalex.org/W2093004120","https://openalex.org/W2093852073","https://openalex.org/W2097665403","https://openalex.org/W2102848008","https://openalex.org/W2106928878","https://openalex.org/W2107272258","https://openalex.org/W2107864184","https://openalex.org/W2116135227","https://openalex.org/W2124356705","https://openalex.org/W2137825653","https://openalex.org/W2144885188","https://openalex.org/W2145082642","https://openalex.org/W2152311269","https://openalex.org/W2161519422","https://openalex.org/W2163611747","https://openalex.org/W2167709602","https://openalex.org/W2170697455","https://openalex.org/W2170768653","https://openalex.org/W2171515016","https://openalex.org/W2182355171","https://openalex.org/W2320569436","https://openalex.org/W2321881523","https://openalex.org/W2325599319","https://openalex.org/W2333620606","https://openalex.org/W2597070792","https://openalex.org/W4236299530","https://openalex.org/W4322387790"],"related_works":["https://openalex.org/W2276905080","https://openalex.org/W7101054479","https://openalex.org/W7100009062","https://openalex.org/W2012157267","https://openalex.org/W2108329413","https://openalex.org/W3010869738","https://openalex.org/W2385104822","https://openalex.org/W1925742305","https://openalex.org/W2326968289","https://openalex.org/W1966994165"],"abstract_inverted_index":{"Acute":[0],"lung":[1,47,77,174],"injury":[2,48,131],"(ALI)":[3],"is":[4,14,182],"a":[5,17,79,163,205],"pulmonary":[6,90,140,188],"inflammatory":[7,102,141],"disorder":[8],"resulting":[9],"in":[10,70,100,119,138,147,167],"respiratory":[11],"failure":[12],"that":[13,180,211],"initiated":[15],"by":[16],"number":[18],"of":[19,57,66,86,111,117,126,136,162,171,200,217],"different":[20,115],"insults":[21],"to":[22,51,62,114,121,186],"the":[23,39,64,71,84,101,124,134,139,148,160,169,187,198,215],"lung.":[24],"Despite":[25],"very":[26],"high":[27],"mortality,":[28],"there":[29],"are":[30],"still":[31],"no":[32],"effective":[33],"treatments":[34],"for":[35,82,89],"this":[36,58,157,220],"disease,":[37],"and":[38,49,88,92,143,203],"main":[40],"supportive":[41],"therapy,":[42],"mechanical":[43],"ventilation,":[44],"can":[45],"further":[46],"contribute":[50],"ALI":[52,201],"progression.":[53],"The":[54,107,154,176],"overall":[55],"objective":[56],"work":[59,85,158],"was":[60],"therefore":[61],"evaluate":[63],"role":[65,135,146],"two":[67],"key":[68],"players":[69],"disease":[72],"process,":[73],"such":[74],"as:":[75],"i)":[76,123],"surfactant,":[78],"material":[80],"essential":[81],"minimizing":[83],"breathing":[87,172],"immunomodulation,":[91],"ii)":[93,133],"matrix":[94],"metalloproteinase":[95],"3":[96],"(MMP-3),":[97],"protease":[98],"involved":[99],"response":[103,142],"associated":[104,151,190],"with":[105,152,191,219],"ALI.":[106,153,192],"experimental":[108],"approach":[109],"consisted":[110],"exposing":[112],"mice":[113],"models":[116],"ALI,":[118],"order":[120],"investigate:":[122],"effects":[125],"exogenous":[127],"surfactant":[128,149,165],"administration":[129],"on":[130],"progression,":[132],"MMP-3":[137,145,181],"iii)":[144],"alterations":[150],"findings":[155],"from":[156],"underline":[159],"importance":[161],"functional":[164],"system":[166],"supporting":[168],"mechanics":[170],"following":[173],"injury.":[175],"data":[177],"also":[178],"illustrate":[179],"an":[183],"important":[184],"contributor":[185],"inflammation":[189],"This":[193],"exciting":[194],"evidence":[195],"has":[196],"broadened":[197],"knowledge":[199],"pathophysiology":[202],"identified":[204],"potential":[206],"new":[207],"therapeutic":[208],"target":[209],"\u2013MMP-3-":[210],"could":[212],"help":[213],"improve":[214],"outcome":[216],"patients":[218],"condition.":[221]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
