{"id":"https://openalex.org/W143758736","doi":null,"title":"Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation","display_name":"Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W143758736","mag":"143758736"},"language":"en","primary_location":{"id":"pmh:oai:researchcommons.waikato.ac.nz:10289/5709","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10289/5709","pdf_url":"https://hdl.handle.net/10289/5709","source":{"id":"https://openalex.org/S7407063277","display_name":"Research Commons (University of Waikato)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10289/5709","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075684728","display_name":"Richard J. Lobb","orcid":"https://orcid.org/0000-0001-9548-8843","observed_orcids":["https://orcid.org/0000-0001-9548-8843"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Richard J. Lobb","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9548-8843","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075684728"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.8920000195503235},{"id":"https://openalex.org/keywords/methylseleninic-acid","display_name":"methylseleninic acid","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.7260000109672546},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress-response","display_name":"endoplasmic reticulum stress response","score":0.949999988079071},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8889999985694885},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.8939999938011169},{"id":"https://openalex.org/keywords/xbp1-splicing","display_name":"XBP1 splicing","score":0.675000011920929},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.6480000019073486},{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pharmacodynamic-markers","display_name":"pharmacodynamic biomarkers","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6047545671463013},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.4819938540458679},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38115882873535156},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3788362741470337},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33322685956954956},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.33097994327545166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2773473858833313},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19973307847976685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19015267491340637},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:researchcommons.waikato.ac.nz:10289/5709","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10289/5709","pdf_url":"https://hdl.handle.net/10289/5709","source":{"id":"https://openalex.org/S7407063277","display_name":"Research Commons (University of Waikato)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:143758736","doi":null,"is_oa":false,"landing_page_url":"https://researchcommons.waikato.ac.nz/handle/10289/5709","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:researchcommons.waikato.ac.nz:10289/5709","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10289/5709","pdf_url":"https://hdl.handle.net/10289/5709","source":{"id":"https://openalex.org/S7407063277","display_name":"Research Commons (University of Waikato)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W143758736.pdf","grobid_xml":"https://content.openalex.org/works/W143758736.grobid-xml"},"referenced_works_count":189,"referenced_works":["https://openalex.org/W133690197","https://openalex.org/W286304560","https://openalex.org/W1208971950","https://openalex.org/W1499700118","https://openalex.org/W1514403557","https://openalex.org/W1544068855","https://openalex.org/W1546139069","https://openalex.org/W1555209755","https://openalex.org/W1582872071","https://openalex.org/W1600542667","https://openalex.org/W1641384127","https://openalex.org/W1657164784","https://openalex.org/W1745634660","https://openalex.org/W1800067576","https://openalex.org/W1922652708","https://openalex.org/W1945179640","https://openalex.org/W1953101143","https://openalex.org/W1963782437","https://openalex.org/W1965773237","https://openalex.org/W1967189897","https://openalex.org/W1967961702","https://openalex.org/W1968418764","https://openalex.org/W1968751935","https://openalex.org/W1969881152","https://openalex.org/W1970090817","https://openalex.org/W1970329613","https://openalex.org/W1970567191","https://openalex.org/W1970577073","https://openalex.org/W1971367575","https://openalex.org/W1974693247","https://openalex.org/W1975129370","https://openalex.org/W1977024706","https://openalex.org/W1977383871","https://openalex.org/W1977540067","https://openalex.org/W1977692360","https://openalex.org/W1978843688","https://openalex.org/W1978927588","https://openalex.org/W1980107234","https://openalex.org/W1980411311","https://openalex.org/W1980635520","https://openalex.org/W1980654848","https://openalex.org/W1980969323","https://openalex.org/W1980969730","https://openalex.org/W1981075283","https://openalex.org/W1984982224","https://openalex.org/W1986721511","https://openalex.org/W1988098314","https://openalex.org/W1989565001","https://openalex.org/W1990521725","https://openalex.org/W1991999080","https://openalex.org/W1994139177","https://openalex.org/W1996604197","https://openalex.org/W1996828342","https://openalex.org/W1998974565","https://openalex.org/W1999344986","https://openalex.org/W2000000541","https://openalex.org/W2001475633","https://openalex.org/W2001893747","https://openalex.org/W2002209113","https://openalex.org/W2007262737","https://openalex.org/W2008714118","https://openalex.org/W2010581370","https://openalex.org/W2014674051","https://openalex.org/W2016777874","https://openalex.org/W2017956920","https://openalex.org/W2018291504","https://openalex.org/W2019433394","https://openalex.org/W2020571246","https://openalex.org/W2022183036","https://openalex.org/W2023851673","https://openalex.org/W2025511820","https://openalex.org/W2026985136","https://openalex.org/W2027158785","https://openalex.org/W2027629550","https://openalex.org/W2029190929","https://openalex.org/W2029207655","https://openalex.org/W2029610054","https://openalex.org/W2030184139","https://openalex.org/W2032767070","https://openalex.org/W2033281614","https://openalex.org/W2034485370","https://openalex.org/W2035066532","https://openalex.org/W2036677133","https://openalex.org/W2041941808","https://openalex.org/W2042320307","https://openalex.org/W2043610941","https://openalex.org/W2044000184","https://openalex.org/W2044068299","https://openalex.org/W2045786144","https://openalex.org/W2048553024","https://openalex.org/W2049519387","https://openalex.org/W2050428134","https://openalex.org/W2050752508","https://openalex.org/W2050962195","https://openalex.org/W2051059335","https://openalex.org/W2052075736","https://openalex.org/W2052673666","https://openalex.org/W2053445526","https://openalex.org/W2053665073","https://openalex.org/W2056984964","https://openalex.org/W2058117893","https://openalex.org/W2059939004","https://openalex.org/W2064546950","https://openalex.org/W2067649147","https://openalex.org/W2068301043","https://openalex.org/W2069041300","https://openalex.org/W2070513297","https://openalex.org/W2072401522","https://openalex.org/W2072610101","https://openalex.org/W2072889522","https://openalex.org/W2074154821","https://openalex.org/W2074824347","https://openalex.org/W2075824842","https://openalex.org/W2075880922","https://openalex.org/W2076485183","https://openalex.org/W2077571136","https://openalex.org/W2078543262","https://openalex.org/W2080364251","https://openalex.org/W2080883315","https://openalex.org/W2081050806","https://openalex.org/W2081294646","https://openalex.org/W2081471267","https://openalex.org/W2083743528","https://openalex.org/W2085315168","https://openalex.org/W2085609942","https://openalex.org/W2087724791","https://openalex.org/W2092629964","https://openalex.org/W2093158584","https://openalex.org/W2093198875","https://openalex.org/W2094305716","https://openalex.org/W2096136751","https://openalex.org/W2098890352","https://openalex.org/W2099579977","https://openalex.org/W2100347985","https://openalex.org/W2101748704","https://openalex.org/W2102056087","https://openalex.org/W2106495603","https://openalex.org/W2108607068","https://openalex.org/W2114918609","https://openalex.org/W2115205812","https://openalex.org/W2115954319","https://openalex.org/W2116488711","https://openalex.org/W2119882170","https://openalex.org/W2120103843","https://openalex.org/W2120379833","https://openalex.org/W2120722077","https://openalex.org/W2120924736","https://openalex.org/W2122080728","https://openalex.org/W2125095236","https://openalex.org/W2126530235","https://openalex.org/W2127906377","https://openalex.org/W2131632095","https://openalex.org/W2132878122","https://openalex.org/W2133309806","https://openalex.org/W2133644385","https://openalex.org/W2135594199","https://openalex.org/W2136887681","https://openalex.org/W2144026946","https://openalex.org/W2145085259","https://openalex.org/W2145200068","https://openalex.org/W2146825351","https://openalex.org/W2147189926","https://openalex.org/W2147336345","https://openalex.org/W2150663029","https://openalex.org/W2151302130","https://openalex.org/W2153313089","https://openalex.org/W2153392167","https://openalex.org/W2153612421","https://openalex.org/W2154455873","https://openalex.org/W2155884826","https://openalex.org/W2157898900","https://openalex.org/W2158736644","https://openalex.org/W2159797128","https://openalex.org/W2160917719","https://openalex.org/W2162542545","https://openalex.org/W2163536007","https://openalex.org/W2163893923","https://openalex.org/W2164277862","https://openalex.org/W2164390141","https://openalex.org/W2165125887","https://openalex.org/W2167731829","https://openalex.org/W2168433858","https://openalex.org/W2168807041","https://openalex.org/W2169302611","https://openalex.org/W2171554935","https://openalex.org/W2231666798","https://openalex.org/W2412802428","https://openalex.org/W2413146406","https://openalex.org/W2474103041"],"related_works":["https://openalex.org/W2962727123","https://openalex.org/W2897584777","https://openalex.org/W2323878311","https://openalex.org/W3024251273","https://openalex.org/W2744026842","https://openalex.org/W2121219636","https://openalex.org/W4390168843","https://openalex.org/W1970567191","https://openalex.org/W2995222326","https://openalex.org/W1984982224"],"abstract_inverted_index":{"Selenium":[0],"(Se)":[1],"is":[2,100,259,400],"an":[3,22],"essential":[4],"trace":[5],"mineral":[6],"required":[7,101],"in":[8,11,55,112,174,182,200,230,256,272,280,284,305,307,332,346,354,452,465,482,501],"maintaining":[9],"health":[10],"humans.":[12],"Recent":[13],"research":[14],"has":[15],"demonstrated":[16,51],"that":[17,24,157,226,295],"Se":[18,49,61,73,144,178,343,472],"shows":[19],"promise":[20],"as":[21],"agent":[23],"can":[25],"reduce":[26],"the":[27,39,76,86,90,135,139,159,212,238,249,398,410,424,435,448],"harmful":[28],"side-effects":[29],"of":[30,41,48,57,78,129,138,142,161,227,240,251,268,289,319,339,342,370,426,432,450,486,505],"chemotherapy":[31,163],"(CT)":[32],"and":[33,59,118,151,155,186,190,242,300,349,373,376,408,434,442,477,488,508],"radiotherapy":[34],"(RT),":[35],"while":[36],"not":[37,82,115,220,401],"compromising":[38,248],"effectiveness":[40],"treatment.":[42,311,396,471],"Clinical":[43],"evaluations":[44,171],"using":[45],"varying":[46],"doses":[47],"have":[50],"a":[52,143,177,231,327,355,366,391,453],"significant":[53],"reduction":[54],"toxicity":[56],"CT":[58,241],"RT.":[60],"supplementation":[62],"appears":[63],"to":[64,123,133,211,261,264,274,286,309,326,334,379,394,414,444,462,496],"mediate":[65],"its":[66],"biological":[67,136,340],"effects":[68,88,160,199,494],"through":[69,85],"four":[70],"main":[71],"mechanisms:":[72],"treatment":[74,236,404,415,451],"promotes":[75],"death":[77],"malignant":[79,116,150,313,478,491],"cells,":[80,84],"but":[81,114],"normal":[83,113],"differential":[87,140,198],"on":[89,149],"endoplasmic":[91],"reticulum":[92],"stress":[93,291,458,510],"response;":[94],"it":[95,108,119,224],"inhibits":[96],"hypoxia-induced":[97],"angiogenesis":[98,433],"which":[99,324],"by":[102,503],"tumours":[103],"for":[104,188,387],"their":[105],"blood":[106,202],"supply;":[107],"enhances":[109],"DNA":[110],"repair":[111],"cells;":[117],"reverses":[120],"cellular":[121],"resistance":[122],"some":[124],"cytotoxic":[125],"drugs.":[126],"The":[127,312],"objectives":[128],"this":[130,428],"thesis":[131],"were":[132,172,303,344,363,377,440,460],"evaluate":[134],"characteristics":[137],"impact":[141],"compound,":[145],"methylseleninic":[146],"acid":[147],"(MSA),":[148],"non-malignant":[152,476],"human":[153],"cells":[154,204,229,246,258,315],"how":[156],"modulates":[158],"cisplatin":[162,185,372,487],"and/or":[164],"radiation.":[165],"In":[166,276],"parallel":[167],"with":[168,184,365,416],"this,":[169],"similar":[170],"undertaken":[173],"patients":[175,353,469],"receiving":[176],"compound":[179],"or":[180,384,418],"placebo":[181,386,419],"conjunction":[183],"radiation":[187],"head":[189],"neck":[191],"squamous":[192],"cell":[193],"carcinoma":[194],"(HNSCC).":[195],"MSA":[196,218,235,310],"induced":[197],"peripheral":[201],"mononuclear":[203],"(PBMC)":[205],"obtained":[206,467],"from":[207,351,468],"healthy":[208],"individuals":[209],"compared":[210],"monocytic":[213],"leukaemia":[214],"THP-1":[215,228,245,257,314],"cell-line.":[216],"While":[217],"did":[219],"change":[221,446],"PBMC":[222,281,306,350,466],"viability,":[223],"reduced":[225,266],"concentration-dependent":[232],"manner.":[233,455],"Furthermore,":[234],"enhanced":[237],"cytotoxicity":[239],"RT":[243,374,489],"toward":[244],"without":[247],"survival":[250],"PBMC.":[252],"This":[253,480],"increased":[254,325,483],"sensitivity":[255],"likely":[260],"be":[262,421,463,497],"related":[263],"significantly":[265,445],"levels":[267,279,318],"intracellular":[269,506],"glutathione":[270,437],"(GSH)":[271],"response":[273,285,292,308,333,511],"MSA.":[275,287,335],"contrast,":[277],"GSH":[278,507],"rose":[282],"substantially":[283],"Assessment":[288],"ER":[290,457,509],"proteins":[293,297,321,512],"revealed":[294],"pro-survival":[296,320],"(GRP78,":[298],"phospho-eIF2\u03b1,":[299],"spliced":[301],"XBP-1)":[302],"upregulated":[304],"had":[316],"high":[317],"at":[322,423,499],"baseline,":[323],"variable":[328],"degree,":[329],"especially":[330],"caspase-8,":[331],"Putative":[336],"pharmacodynamic":[337,411],"markers":[338,431,459],"activity":[341],"evaluated":[345],"plasma":[347],"samples":[348],"HNSCC":[352],"randomised,":[356],"placebo-controlled,":[357],"double-blind":[358],"phase":[359],"II":[360],"trial.":[361],"Patients":[362],"treated":[364],"7-week":[367],"radical":[368],"course":[369,449],"concurrent":[371],"(CRT)":[375],"randomised":[378],"receive":[380],"either":[381],"selenomethionine":[382],"(SLM)":[383],"matching":[385],"11":[388],"weeks,":[389],"starting":[390],"week":[392],"prior":[393],"CRT":[395],"Because":[397],"trial":[399],"yet":[402],"complete,":[403],"allocation":[405],"remains":[406],"blinded":[407],"thus":[409],"results":[412,481],"according":[413],"SLM":[417],"cannot":[420],"made":[422],"time":[425],"writing":[427],"thesis.":[429],"However,":[430],"selenoprotein":[436],"peroxidise":[438],"3":[439],"measured":[441],"shown":[443,461],"during":[447,470],"patient-specific":[454],"Lastly,":[456],"detected":[464],"compounds":[473],"differentially":[474],"affect":[475],"cells.":[479,492],"therapeutic":[484],"efficacy":[485],"targeting":[490],"These":[493],"appear":[495],"mediated,":[498],"least":[500],"part,":[502],"modulation":[504]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
