{"id":"https://openalex.org/W143728663","doi":null,"title":"Urinary Excretion of (1-3)-Beta-D-Glucans.","display_name":"Urinary Excretion of (1-3)-Beta-D-Glucans.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W143728663","mag":"143728663"},"language":"en","primary_location":{"id":"pmh:oai:dc.etsu.edu:etd-3354","doi":null,"is_oa":true,"landing_page_url":"https://dc.etsu.edu/etd/2002","pdf_url":"https://dc.etsu.edu/etd/2002","source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dc.etsu.edu/etd/2002","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089175164","display_name":"Debra K. Head","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Debra K. Head","raw_affiliation_strings":["East Tennessee State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Tennessee State University","institution_ids":["https://openalex.org/I119443389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089175164"],"corresponding_institution_ids":["https://openalex.org/I119443389"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.059700001031160355,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-1-3-glucan","display_name":"\u03b2-1,3-glucan","score":0.9490000009536743},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.8379999995231628},{"id":"https://openalex.org/keywords/fungal-cell-wall-polysaccharides","display_name":"fungal cell wall polysaccharides","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pathogen-associated-molecular-patterns","display_name":"pathogen-associated molecular patterns","score":0.9520000219345093},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5926347970962524},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.41777732968330383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3971250653266907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33568936586380005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2878504991531372},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23579594492912292},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dc.etsu.edu:etd-3354","doi":null,"is_oa":true,"landing_page_url":"https://dc.etsu.edu/etd/2002","pdf_url":"https://dc.etsu.edu/etd/2002","source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},{"id":"mag:143728663","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/cgi/viewcontent.cgi?article=3354&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dc.etsu.edu:etd-3354","doi":null,"is_oa":true,"landing_page_url":"https://dc.etsu.edu/etd/2002","pdf_url":"https://dc.etsu.edu/etd/2002","source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W143728663.pdf","grobid_xml":"https://content.openalex.org/works/W143728663.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W326701634","https://openalex.org/W1897255091","https://openalex.org/W1982234631","https://openalex.org/W1988940275","https://openalex.org/W1991767888","https://openalex.org/W1992458648","https://openalex.org/W1994334475","https://openalex.org/W2002611996","https://openalex.org/W2021961631","https://openalex.org/W2047225913","https://openalex.org/W2075595064","https://openalex.org/W2082653888","https://openalex.org/W2087090790","https://openalex.org/W2093588835","https://openalex.org/W2094987428","https://openalex.org/W2101368523","https://openalex.org/W2105108058","https://openalex.org/W2107531246","https://openalex.org/W2108093856","https://openalex.org/W2108491966","https://openalex.org/W2112183904","https://openalex.org/W2120342840","https://openalex.org/W2126924404","https://openalex.org/W2130699389","https://openalex.org/W2132252339","https://openalex.org/W2135444075","https://openalex.org/W2141338942","https://openalex.org/W2143319348","https://openalex.org/W2143508569","https://openalex.org/W2149569216","https://openalex.org/W2161054210","https://openalex.org/W2215609507","https://openalex.org/W2340245989","https://openalex.org/W4312666166"],"related_works":["https://openalex.org/W2141338942","https://openalex.org/W1517041400","https://openalex.org/W2471811005","https://openalex.org/W7215447918","https://openalex.org/W2330056923","https://openalex.org/W2068232027","https://openalex.org/W3168193573","https://openalex.org/W2402690465","https://openalex.org/W2137520652","https://openalex.org/W1565068111"],"abstract_inverted_index":{"(1\u21923)-\u03b2-D-Glucans":[0],"are":[1,5,17,129],"carbohydrate":[2],"polymers":[3],"that":[4,22],"present":[6,43],"in":[7,65,92],"the":[8,34,42,46,66,93,132],"cell":[9],"wall":[10],"of":[11,36,49,70,89,119,139,147],"various":[12],"fungi":[13],"and":[14,26,38,53,77,84],"bacteria;":[15],"they":[16],"pathogen":[18],"associated":[19],"molecular":[20,105,121],"patterns":[21],"circulate":[23],"during":[24],"infection":[25],"modulate":[27],"immunity.":[28],"Our":[29],"laboratory":[30],"has":[31],"previously":[32],"established":[33],"pharmacokinetics":[35],"intravenously":[37],"orally":[39],"administered":[40,60],"glucans;":[41],"studies":[44],"investigated":[45],"renal":[47],"excretion":[48],"(1\u21923)-\u03b2-D-glucans":[50,128],"following":[51],"intravenous":[52],"oral":[54],"administration.":[55],"Three":[56],"fluorescently-labeled":[57],"glucans":[58,117,141],"were":[59,75,118],"to":[61,111],"adult":[62],"male":[63],"rats":[64],"presence":[67,138],"or":[68],"absence":[69],"toxic":[71],"challenge.":[72],"Urine":[73],"specimens":[74],"collected":[76],"analyzed":[78],"by":[79,131],"fluorescence":[80,90],"spectroscopy,":[81],"size-exclusion":[82],"chromatography":[83],"GPC/MALLS.":[85],"71":[86],"\u00b1":[87,108,124],"3%":[88],"remained":[91],">5K":[94],"MWCO":[95],"fraction;":[96],"this":[97],"fraction":[98],"showed":[99],"a":[100,104],"minor":[101],"peak":[102],"with":[103],"mass":[106,122],"(171":[107],"11K)":[109],"corresponding":[110],"injected":[112],"glucan":[113],"(~150K).":[114],"Most":[115],"excreted":[116,130],"lower":[120],"(13":[123],"8.5K),":[125],"indicating":[126],"most":[127],"kidneys":[133],"as":[134],"smaller":[135],"polysaccharides.":[136],"The":[137],"urinary":[140],"may":[142],"be":[143],"an":[144],"important":[145],"indicator":[146],"fungal":[148],"infection.":[149]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}