{"id":"https://openalex.org/W143363706","doi":null,"title":"Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen.","display_name":"Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen.","publication_year":1996,"publication_date":"1996-02-01","ids":{"openalex":"https://openalex.org/W143363706","mag":"143363706","pmid":"https://pubmed.ncbi.nlm.nih.gov/8932523"},"language":"en","primary_location":{"id":"pmid:8932523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8932523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and molecular biology international","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102817092","display_name":"Rai Ajit K. Srivastava","orcid":"https://orcid.org/0000-0003-1816-3644","observed_orcids":["https://orcid.org/0000-0003-1816-3644"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Srivastava","raw_affiliation_strings":["Division of Atherosclerosis, Washington University School of Medicine, Saint Louis, MO 63110, USA. srivasta@visar.wustl.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Atherosclerosis, Washington University School of Medicine, Saint Louis, MO 63110, USA. srivasta@visar.wustl.edu","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067184265","display_name":"Naina Bhasin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Bhasin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087158012","display_name":"Niraj Kumar Srivastava","orcid":"https://orcid.org/0000-0002-5369-4195","observed_orcids":["https://orcid.org/0000-0002-5369-4195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Srivastava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2941,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.88077696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"38","issue":"1","first_page":"91","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.5820000171661377,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.5820000171661377,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.3815999925136566,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8840000033378601},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.6759999990463257},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.6880000233650208},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9879999756813049},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.9120000004768372},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mouse-strains","display_name":"mouse strains","score":0.7919999957084656},{"id":"https://openalex.org/keywords/c3h-mice","display_name":"C3H mice","score":0.7630000114440918},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.460999995470047},{"id":"https://openalex.org/keywords/translatable-mrna","display_name":"translatable mRNA","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8318933844566345},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7132541537284851},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.69044429063797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6574709415435791},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.572515070438385},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5377412438392639},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5273352861404419},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5266525745391846},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5033113360404968},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.41947585344314575},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2317909598350525},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2073308229446411},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11222520470619202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015347","descriptor_name":"RNA Probes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8932523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8932523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and molecular biology international","raw_type":"Journal Article"},{"id":"mag:143363706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8932523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1964889935","display_name":"Diabetes Research & Training Center","funder_award_id":"5p60dk020579-35","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965834391","https://openalex.org/W2423954889","https://openalex.org/W2064501387","https://openalex.org/W4245679449","https://openalex.org/W1497692202","https://openalex.org/W2069028182","https://openalex.org/W164958898","https://openalex.org/W810656112","https://openalex.org/W2440952913","https://openalex.org/W2008377776"],"abstract_inverted_index":{"Apolipoprotein":[0],"(apo)":[1],"E":[2,32],"is":[3,33],"associated":[4,35],"with":[5,36,109],"several":[6],"classes":[7],"of":[8,20,30,40,48,56,67,91,99,119,140,161,187,200,215,253],"lipoproteins":[9],"and":[10,25,38,54,62,77,125,145,158,185,238],"serves":[11],"as":[12],"a":[13,233],"ligand":[14],"for":[15,175],"the":[16,89,201,213,220,244],"receptor":[17],"mediated":[18],"uptake":[19],"cholesterol-rich":[21],"particles":[22],"by":[23,64,73,81,165,246],"hepatocytes":[24],"peripheral":[26],"tissues.":[27],"Variant":[28],"forms":[29],"apo":[31],"also":[34,95,149],"dyslipidemia":[37],"late-onset":[39,252],"Alzheimer's":[41,254],"Disease":[42],"(AD).":[43],"We":[44],"report":[45],"here":[46],"expression":[47,164,231],"apoE":[49,57,79,100,127,141,162,192,217,229,241],"in":[50,58,82,103,112,154,181,198,212,219,232,236,240,243,251],"various":[51],"mouse":[52,189,202],"tissues,":[53],"regulation":[55],"liver,":[59,182],"kidney,":[60,183],"brain":[61,184,216,245],"testes":[63,144,186],"supraphysiological":[65],"doses":[66],"estrogen.":[68],"ApoE":[69,147],"mRNA":[70,80,93,128,193,218,242],"was":[71,148,179,209],"quantified":[72],"RNase":[74],"protection":[75],"assay":[76],"translatable":[78,126],"vitro":[83],"translation.":[84],"As":[85],"an":[86],"internal":[87],"control":[88],"levels":[90,98,111,118,139,214],"beta-actin":[92],"were":[94,101,142],"quantified.":[96],"Highest":[97],"expressed":[102,116,136,153],"liver":[104],"(220-280":[105],"pg/mu":[106,122],"g":[107,123,169,171],"RNA)":[108,124],"negligible":[110],"small":[113],"intestine.":[114],"Brain":[115],"highest":[117],"total":[120],"(35-40":[121],"next":[129],"only":[130],"to":[131,151],"liver.":[132],"Other":[133],"tissues":[134],"that":[135,226],"relatively":[137],"higher":[138],"adrenals,":[143],"ovary.":[146],"found":[150],"be":[152],"heart,":[155],"lung,":[156],"kidney":[157],"spleen.":[159],"Regulation":[160],"gene":[163,230],"estrogen":[166,227,247],"(3":[167],"mu":[168],"17beta-estradiol/":[170],"body":[172],"weight/":[173],"day":[174],"5":[176],"consecutive":[177],"days)":[178],"studied":[180],"4":[188],"strains.":[190],"Hepatic":[191],"did":[194],"not":[195],"change":[196],"significantly":[197],"any":[199],"strains":[203],"following":[204],"estradiol":[205],"administration.":[206],"Of":[207],"note":[208],"significant":[210],"increases":[211,239],"strain":[221],"C3H.":[222],"These":[223],"studies":[224],"demonstrate":[225],"regulates":[228],"tissue-specific":[234],"manner":[235],"mice,":[237],"may":[248],"have":[249],"implications":[250],"Disease.":[255]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
