{"id":"https://openalex.org/W143293162","doi":"https://doi.org/10.1096/fasebj.21.5.a106-a","title":"Selenium, isoflavones, and AR\u2010regulated genes in rat prostate","display_name":"Selenium, isoflavones, and AR\u2010regulated genes in rat prostate","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W143293162","doi":"https://doi.org/10.1096/fasebj.21.5.a106-a","mag":"143293162"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a106-a","doi":"https://doi.org/10.1096/fasebj.21.5.a106-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a106-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086390112","display_name":"Russell L. Legg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russell Legg","raw_affiliation_strings":["Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059685883","display_name":"Jessica R Tolman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Tolman","raw_affiliation_strings":["Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061234578","display_name":"Cameron T Lovinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cameron Lovinger","raw_affiliation_strings":["Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031905494","display_name":"Edwin D. Lephart","orcid":"https://orcid.org/0000-0003-2027-9187","observed_orcids":["https://orcid.org/0000-0003-2027-9187"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Lephart","raw_affiliation_strings":["Physiology, Developmental Biology &amp; Neuroscience Brigham Young University S\u2010235 ESC Provo UT 84602"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, Developmental Biology &amp; Neuroscience Brigham Young University S\u2010235 ESC Provo UT 84602","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036804110","display_name":"Kenneth D.R. Setchell","orcid":"https://orcid.org/0000-0001-9147-0136","observed_orcids":["https://orcid.org/0000-0001-9147-0136"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Setchell","raw_affiliation_strings":["Pediatrics Children' Hospital Medical Center 3333 Burnet Avenue Cincinnati OH 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics Children' Hospital Medical Center 3333 Burnet Avenue Cincinnati OH 45229","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102161804","display_name":"Merrill J. Christensen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merrill Christensen","raw_affiliation_strings":["Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02116507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.4641000032424927,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.4641000032424927,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.9330000281333923},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prostate-cancer-chemoprevention","display_name":"prostate cancer chemoprevention","score":0.9269999861717224},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dietary-isoflavones","display_name":"dietary isoflavones","score":0.6620000004768372},{"id":"https://openalex.org/keywords/equol","display_name":"equol","score":0.6520000100135803},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.8769999742507935},{"id":"https://openalex.org/keywords/daidzein","display_name":"daidzein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dorsolateral-prostate","display_name":"dorsolateral prostate","score":0.7900000214576721},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6449999809265137},{"id":"https://openalex.org/keywords/arsenic-trichloride","display_name":"arsenic trichloride","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gucy1a3","display_name":"GUCY1A3","score":0.972000002861023},{"id":"https://openalex.org/keywords/abcc4","display_name":"ABCC4","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dhcr24","display_name":"DHCR24","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.919068455696106},{"id":"https://openalex.org/C2780955279","wikidata":"https://www.wikidata.org/wiki/Q408732","display_name":"Daidzein","level":3,"score":0.9033511877059937},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.8907333612442017},{"id":"https://openalex.org/C2781262405","wikidata":"https://www.wikidata.org/wiki/Q5384747","display_name":"Equol","level":4,"score":0.7386001944541931},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6719878911972046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6393673419952393},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.548395037651062},{"id":"https://openalex.org/C2778270713","wikidata":"https://www.wikidata.org/wiki/Q414496","display_name":"Phytoestrogens","level":3,"score":0.4725746214389801},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.45876994729042053},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44143807888031006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30146607756614685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.298503577709198},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2803623080253601},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.10769662261009216}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a106-a","doi":"https://doi.org/10.1096/fasebj.21.5.a106-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a106-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.44999998807907104}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5577452714","display_name":"Selenium, Isoflavones, Androgen Metabolism and Prostate Cancer Risk Reduction","funder_award_id":"R15CA122235","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2100799274","https://openalex.org/W748024326","https://openalex.org/W2151573861","https://openalex.org/W784653086","https://openalex.org/W7097185031","https://openalex.org/W1973686522","https://openalex.org/W3173283895","https://openalex.org/W1903014736","https://openalex.org/W2140703605","https://openalex.org/W2025894464"],"abstract_inverted_index":{"This":[0],"study":[1],"aimed":[2],"to":[3,24,126],"identify":[4],"potential":[5],"prostate":[6,132],"cancer":[7],"chemopreventive":[8,198],"effects":[9],"of":[10,14,43,156,170,180,188],"combined":[11],"high":[12,34,142,189,192],"intake":[13,187],"Se":[15,46,101,143,177,190],"and":[16,89,138,153,160,173,183,191],"isoflavones.":[17,107],"Subjects":[18],"were":[19,115,163],"Noble":[20],"male":[21],"rats":[22,84,95],"born":[23],"breeders":[25],"fed":[26,85,96],"stock":[27],"diets":[28,54],"containing":[29],"low":[30],"(10":[31],"ppm)":[32,36],"or":[33,39],"(600":[35],"isoflavones,":[37,88],"with":[38],"without":[40],"a":[41,196],"supplement":[42],"3":[44],"ppm":[45,87,98],"as":[47,55],"Se\u2010methylselenocysteine.":[48],"Pups":[49],"continued":[50],"consuming":[51],"the":[52],"same":[53],"their":[56],"parents":[57],"until":[58],"sacrifice":[59],"at":[60],"200":[61],"days.":[62],"Liver":[63],"glutathione":[64],"peroxidase":[65],"activity":[66],"was":[67],"unaffected":[68],"by":[69,206],"diets.":[70,99],"Serum":[71],"isoflavone":[72],"(equol+genistein+daidzein)":[73],"concentrations":[74],"averaged":[75],"23.5":[76],"+":[77,81,91],"2.4":[78],"ng/ml":[79,93],"(mean":[80],"SD)":[82],"in":[83,94,112,131],"10":[86],"1457":[90],"273":[92],"600":[97],"Dietary":[100],"had":[102],"no":[103],"effect":[104,199],"on":[105],"serum":[106],"Steady":[108],"state":[109],"mRNA":[110,157],"levels":[111],"dorsolateral":[113],"prostates":[114],"determined":[116],"for":[117,140,158],"genes":[118,148],"which":[119,141],"previous":[120],"data":[121],"mining":[122],"(Zhang":[123],"2005)":[124],"showed":[125],"be":[127],"1)":[128],"differentially":[129],"regulated":[130],"cancer;":[133],"2)":[134],"androgen":[135],"receptor":[136],"(AR)\u2010regulated;":[137],"3)":[139],"countered":[144],"AR":[145,161],"effects.":[146],"These":[147],"included":[149],"Abcc4,":[150,182],"Dhcr24,":[151],"Ascl3,":[152,172],"Gucyla3.":[154],"Levels":[155],"Akr1c6":[159],"(large)":[162],"also":[164],"assayed.":[165],"High":[166,176],"isoflavones":[167,193],"decreased":[168,178],"expression":[169,179],"Akr1c6,":[171],"Gucy1a3":[174],"(p=.000\u2013.003).":[175],"AR,":[181],"Dhcr24":[184],"(p=.000\u2013.012).":[185],"Combined":[186],"may":[194],"achieve":[195],"greater":[197],"that":[200],"either":[201],"compound":[202],"supplemented":[203],"individually.":[204],"(Supported":[205],"NIH":[207],"CA122235).":[208]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
