{"id":"https://openalex.org/W143139346","doi":null,"title":"The temperature-dependence of human erythrocyte acetylcholinesterase activity is not affected by membrane cholesterol enrichment.","display_name":"The temperature-dependence of human erythrocyte acetylcholinesterase activity is not affected by membrane cholesterol enrichment.","publication_year":1988,"publication_date":"1988-10-15","ids":{"openalex":"https://openalex.org/W143139346","mag":"143139346","pmid":"https://pubmed.ncbi.nlm.nih.gov/3202833","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1135263"},"language":"en","primary_location":{"id":"pmid:3202833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3202833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1135263/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069906617","display_name":"Angelo Spinedi","orcid":"https://orcid.org/0000-0002-5292-5692","observed_orcids":["https://orcid.org/0000-0002-5292-5692"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Spinedi","raw_affiliation_strings":["Department of Biology, University of Rome, Tor Vergata, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rome, Tor Vergata, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050803435","display_name":"Stefano Rufini","orcid":"https://orcid.org/0000-0001-6682-6524","observed_orcids":["https://orcid.org/0000-0001-6682-6524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rufini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072185558","display_name":"Paolo Luly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Luly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111725968","display_name":"Ricardo N. Far\u00edas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R N Farias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.446,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.54609604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"255","issue":"2","first_page":"547","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/human-erythrocyte-membrane","display_name":"human erythrocyte membrane","score":0.875},{"id":"https://openalex.org/keywords/membrane-cholesterol","display_name":"membrane cholesterol","score":0.6520000100135803},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.7059999704360962},{"id":"https://openalex.org/keywords/lipid-order-parameter","display_name":"lipid order parameter","score":0.9570000171661377},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.6290000081062317},{"id":"https://openalex.org/keywords/arrhenius-plot","display_name":"Arrhenius plot","score":0.8370000123977661},{"id":"https://openalex.org/keywords/enzyme-conformation","display_name":"enzyme conformation","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C8739425","wikidata":"https://www.wikidata.org/wiki/Q695171","display_name":"Arrhenius plot","level":3,"score":0.9480024576187134},{"id":"https://openalex.org/C86183883","wikidata":"https://www.wikidata.org/wiki/Q507505","display_name":"Arrhenius equation","level":3,"score":0.7911617755889893},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7165706753730774},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.7095955014228821},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6106038093566895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5665816068649292},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5523951649665833},{"id":"https://openalex.org/C2993443003","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Erythrocyte membrane","level":3,"score":0.47925543785095215},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44414210319519043},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.4437291920185089},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.4118683934211731},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3902427554130554},{"id":"https://openalex.org/C95121573","wikidata":"https://www.wikidata.org/wiki/Q190474","display_name":"Activation energy","level":2,"score":0.28267669677734375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24517184495925903},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08756613731384277}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017830","descriptor_name":"Octoxynol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:3202833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3202833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1135263","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1135263/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmh:oai:art.torvergata.it:2108/54833","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/54833","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:143139346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3202833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1135263","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1135263/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W32280788","https://openalex.org/W343205484","https://openalex.org/W1494255360","https://openalex.org/W1563813749","https://openalex.org/W1580340943","https://openalex.org/W1591818435","https://openalex.org/W1775749144","https://openalex.org/W1871203289","https://openalex.org/W1964106965","https://openalex.org/W1969498304","https://openalex.org/W1971048984","https://openalex.org/W1975379307","https://openalex.org/W1980866266","https://openalex.org/W1982749495","https://openalex.org/W1986232872","https://openalex.org/W1991832287","https://openalex.org/W1997243937","https://openalex.org/W2020578605","https://openalex.org/W2037528416","https://openalex.org/W2040455341","https://openalex.org/W2053255553","https://openalex.org/W2061124406","https://openalex.org/W2072627505","https://openalex.org/W2080464418","https://openalex.org/W2104606868","https://openalex.org/W2104706063","https://openalex.org/W2126996117","https://openalex.org/W2128467837","https://openalex.org/W2152311269","https://openalex.org/W2168217043","https://openalex.org/W2243407002","https://openalex.org/W2267123302","https://openalex.org/W2341968368","https://openalex.org/W2473420188"],"related_works":["https://openalex.org/W2168217043","https://openalex.org/W1871203289","https://openalex.org/W2008736910","https://openalex.org/W1969498304","https://openalex.org/W2025433562","https://openalex.org/W1988329542","https://openalex.org/W2408982181","https://openalex.org/W2318458693","https://openalex.org/W2264152320","https://openalex.org/W2441573798"],"abstract_inverted_index":{"The":[0],"temperature-dependence":[1,34],"of":[2,35,45,64,74,85],"both":[3],"the":[4,33,42,46,55,58,61,65],"lipid":[5,38],"order":[6,39],"parameter":[7],"(SDPH)":[8],"and":[9,15],"acetylcholinesterase":[10],"(AChE)":[11],"activity":[12,48,67],"from":[13,81],"native":[14,36],"cholesterol-enriched":[16],"human":[17],"erythrocyte":[18],"membranes":[19],"was":[20],"investigated.":[21],"Cholesterol":[22],"enrichment":[23],"abolishes":[24],"an":[25],"inflection":[26],"observed":[27],"around":[28],"30":[29],"degrees":[30],"C":[31],"in":[32,60],"membrane":[37,76],"parameter,":[40],"whereas":[41],"Arrhenius":[43,62],"plot":[44,63],"enzymic":[47],"is":[49],"substantially":[50],"unaffected.":[51],"These":[52],"results":[53],"support":[54],"view":[56],"that":[57],"breaks":[59],"enzyme":[66,88],"are":[68],"not":[69],"related":[70],"to":[71],"sudden":[72],"changes":[73],"bulk":[75],"physical":[77],"state,":[78],"but":[79],"arise":[80],"a":[82],"direct":[83],"effect":[84],"temperature":[86],"on":[87],"conformation.":[89]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
