{"id":"https://openalex.org/W1430249158","doi":"https://doi.org/10.1182/blood.v122.21.3070.3070","title":"Genetic Factors Predicting The Response To BET Bromodomain Inhibitors In Lymphoma Lead To New Synergistic Combinations","display_name":"Genetic Factors Predicting The Response To BET Bromodomain Inhibitors In Lymphoma Lead To New Synergistic Combinations","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W1430249158","doi":"https://doi.org/10.1182/blood.v122.21.3070.3070","mag":"1430249158"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.3070.3070","doi":"https://doi.org/10.1182/blood.v122.21.3070.3070","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.3070.3070","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103083472","display_name":"Eugenio Gaudio","orcid":"https://orcid.org/0000-0002-0724-1590","observed_orcids":["https://orcid.org/0000-0002-0724-1590"]},"institutions":[{"id":"https://openalex.org/I4210101830","display_name":"Institute of Oncology Research","ror":"https://ror.org/01dpyn972","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210101830","https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Eugenio Gaudio","raw_affiliation_strings":["Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,","institution_ids":["https://openalex.org/I4210101830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079771818","display_name":"Ivo Kwee","orcid":"https://orcid.org/0000-0002-2751-4218","observed_orcids":["https://orcid.org/0000-0002-2751-4218"]},"institutions":[{"id":"https://openalex.org/I2614128279","display_name":"Dalle Molle Institute for Artificial Intelligence Research","ror":"https://ror.org/013355g38","country_code":"CH","type":"facility","lineage":["https://openalex.org/I15196421","https://openalex.org/I2614128279","https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Ivo Kwee","raw_affiliation_strings":["Dalle Molle Institute for Artificial Intelligence (IDSIA), Manno, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dalle Molle Institute for Artificial Intelligence (IDSIA), Manno, Switzerland,","institution_ids":["https://openalex.org/I2614128279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039188583","display_name":"Andrea Rinaldi","orcid":"https://orcid.org/0000-0003-3234-0563","observed_orcids":["https://orcid.org/0000-0003-3234-0563"]},"institutions":[{"id":"https://openalex.org/I4210101830","display_name":"Institute of Oncology Research","ror":"https://ror.org/01dpyn972","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210101830","https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Andrea Rinaldi","raw_affiliation_strings":["Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,","institution_ids":["https://openalex.org/I4210101830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073467962","display_name":"Michela Boi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101830","display_name":"Institute of Oncology Research","ror":"https://ror.org/01dpyn972","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210101830","https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Michela Boi","raw_affiliation_strings":["Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,","institution_ids":["https://openalex.org/I4210101830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054086723","display_name":"Elena Bernasconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101830","display_name":"Institute of Oncology Research","ror":"https://ror.org/01dpyn972","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210101830","https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Elena Bernasconi","raw_affiliation_strings":["Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,","institution_ids":["https://openalex.org/I4210101830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026796330","display_name":"Monica Testoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101830","display_name":"Institute of Oncology Research","ror":"https://ror.org/01dpyn972","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210101830","https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Monica Testoni","raw_affiliation_strings":["Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphoma & Genomics Research Program, IOR-Institute of Oncology Research, Bellinzona, Switzerland,","institution_ids":["https://openalex.org/I4210101830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048622832","display_name":"Anastasios Stathis","orcid":"https://orcid.org/0000-0002-2859-7529","observed_orcids":["https://orcid.org/0000-0002-2859-7529"]},"institutions":[{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Anastasios Stathis","raw_affiliation_strings":["IOSI-Oncology Institute of Southern Switzerland, Bellinzona, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOSI-Oncology Institute of Southern Switzerland, Bellinzona, Switzerland,","institution_ids":["https://openalex.org/I4404532900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006004932","display_name":"Patrice Herait","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Patrice Herait","raw_affiliation_strings":["OncoEthix SA, Lausanne, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoEthix SA, Lausanne, Switzerland,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111745353","display_name":"Kay Noel","orcid":"https://orcid.org/0009-0001-3006-1897","observed_orcids":["https://orcid.org/0009-0001-3006-1897"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kay Noel","raw_affiliation_strings":["OncoEthix SA, Lausanne, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoEthix SA, Lausanne, Switzerland,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006640724","display_name":"Giorgio Inghirami","orcid":"https://orcid.org/0000-0001-5566-0864","observed_orcids":["https://orcid.org/0000-0001-5566-0864","https://orcid.org/0000-0002-5298-6516"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giorgio Inghirami","raw_affiliation_strings":["Department of Pathology and Center for Experimental Research and Medical Studies (CeRMS), University of Turin, Turin, Italy, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Center for Experimental Research and Medical Studies (CeRMS), University of Turin, Turin, Italy, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102763531","display_name":"Emanuele Zucca","orcid":"https://orcid.org/0000-0002-5522-6109","observed_orcids":["https://orcid.org/0000-0002-5522-6109"]},"institutions":[{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emanuele Zucca","raw_affiliation_strings":["IOSI-Oncology Institute of Southern Switzerland, Bellinzona, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOSI-Oncology Institute of Southern Switzerland, Bellinzona, Switzerland,","institution_ids":["https://openalex.org/I4404532900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066518317","display_name":"Francesco Bertoni","orcid":"https://orcid.org/0000-0001-5637-8983","observed_orcids":["https://orcid.org/0000-0001-5637-8983","https://orcid.org/0000-0002-7301-1208"]},"institutions":[{"id":"https://openalex.org/I4404532900","display_name":"Istituto Oncologico della Svizzera Italiana","ror":"https://ror.org/04tty5b50","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210095212","https://openalex.org/I4404532900"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Francesco Bertoni","raw_affiliation_strings":["IOSI-Oncology Institute of Southern Switzerland, Bellinzona, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IOSI-Oncology Institute of Southern Switzerland, Bellinzona, Switzerland,","institution_ids":["https://openalex.org/I4404532900"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5006004932","https://openalex.org/A5006640724","https://openalex.org/A5026796330","https://openalex.org/A5039188583","https://openalex.org/A5048622832","https://openalex.org/A5054086723","https://openalex.org/A5073467962","https://openalex.org/A5079771818","https://openalex.org/A5103083472","https://openalex.org/A5111745353"],"corresponding_institution_ids":["https://openalex.org/I2614128279","https://openalex.org/I4210101830","https://openalex.org/I4404532900","https://openalex.org/I55143463"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04654557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"3070","last_page":"3070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bet-inhibitors","display_name":"BET inhibitors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/otx015","display_name":"OTX015","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.5699999928474426},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5550000071525574},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.6230000257492065},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5049999952316284},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.5770000219345093},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6010000109672546},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9390000104904175},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.6790000200271606},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.5239999890327454},{"id":"https://openalex.org/keywords/chromatin-regulation","display_name":"chromatin regulation","score":0.4390000104904175},{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.625},{"id":"https://openalex.org/keywords/splenic-marginal-zone-lymphoma","display_name":"splenic marginal zone lymphoma","score":0.7789999842643738},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.926714301109314},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.545313835144043},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5348191857337952},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5152116417884827},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.4878661632537842},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4864308834075928},{"id":"https://openalex.org/C2780862049","wikidata":"https://www.wikidata.org/wiki/Q25326844","display_name":"BET inhibitor","level":5,"score":0.48530739545822144},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.4336458146572113},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4256199300289154},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3198292553424835},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28409379720687866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23984280228614807},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22758716344833374}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.3070.3070","doi":"https://doi.org/10.1182/blood.v122.21.3070.3070","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.3070.3070","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1975632474","https://openalex.org/W2345699850","https://openalex.org/W1567944093","https://openalex.org/W2731003977","https://openalex.org/W2946433345","https://openalex.org/W2028322760","https://openalex.org/W2567290660","https://openalex.org/W7027908747","https://openalex.org/W2086262847","https://openalex.org/W2128605424"],"abstract_inverted_index":{"Abstract":[0],"Epigenome":[1],"deregulation":[2],"in":[3,36,44,75,97,107,161,225,265,302,364,399,450,452,517,534],"cancer":[4],"cells":[5,349,535],"affects":[6],"transcription":[7],"of":[8,50,71,195,221,230,262,292,361,379,383,395,458,465,480,514,532,575,586],"oncogenes":[9],"and":[10,20,38,41,52,60,89,142,210,281,300,315,326,346,377,385,393,401,406,419,426,529,552],"tumor":[11],"suppressor":[12],"genes.":[13],"BET":[14,29,72,94,549],"Bromodomain":[15,30,73,95,550],"proteins":[16],"recognize":[17],"chromatin":[18,271],"modifications":[19],"act":[21],"as":[22,176,411,472,557],"epigenetic":[23],"readers":[24],"contributing":[25,544],"to":[26,93,218,257,375,495,525,545,548,559],"gene":[27,101],"transcription.":[28],"inhibitors":[31,96,551],"showed":[32,358],"promising":[33,553],"pre-clinical":[34],"activity":[35,70],"hematological":[37],"solid":[39],"tumors":[40],"are":[42,56,62],"currently":[43],"phase":[45],"I":[46],"studies.":[47],"The":[48,462,501],"mechanism":[49],"action":[51],"relevant":[53],"affected":[54],"genes":[55,90,197,263,362,405],"not":[57,352],"fully":[58],"characterized":[59],"there":[61,369],"no":[63,371],"established":[64],"response":[65,374,547],"predictors.":[66],"We":[67],"have":[68,429],"shown":[69,473],"OTX015":[74,222,258,288,308,355,442,470,484,498,523],"lymphoma":[76,115],"cell":[77,109,124,266],"lines":[78,110],"(ASH":[79,151],"2012;":[80,152],"ICML":[81,153],"2013).":[82],"This":[83],"study":[84,540],"aimed":[85],"at":[86],"elucidating":[87],"pathways":[88],"affecting":[91],"response/resistance":[92],"lymphomas.":[98],"Methods":[99],"Baseline":[100],"expression":[102,179],"profiles":[103],"(GEP)":[104],"were":[105,145,164,216,259,290,330],"obtained":[106],"38":[108],"[22":[111],"diffuse":[112],"large":[113,119],"B-cell":[114,208,213,274],"(DLBCL),":[116],"8":[117],"anaplastic":[118],"T-cell":[120],"lymphoma,":[121,125,130],"4":[122],"mantle":[123],"3":[126,205],"splenic":[127],"marginal":[128],"zone":[129],"1":[131],"chronic":[132],"lymphocytic":[133],"leukemia]":[134],"with":[135,227,248,255,287,307,332,413,424,432,435,444,454,497,510,519],"Illumina":[136],"HumanHT-12":[137],"v4":[138],"Expression":[139],"BeadChip.":[140],"Genetic":[141],"biologic":[143,386],"information":[144],"collected":[146],"from":[147],"literature.":[148],"GEP/IC50":[149],"correlation":[150],"2013)":[154],"was":[155,181,198,241,370,448],"assessed":[156,242],"by":[157,186,200,237,243,474],"Pearson":[158],"correlation.":[159],"Associations":[160],"two-way":[162],"tables":[163],"tested":[165],"for":[166,233,483],"statistical":[167],"significance":[168],"using":[169,183,190],"either":[170],"chi-square":[171],"or":[172,224,351,403,577,588],"Fisher":[173],"exact":[174],"test,":[175],"appropriate.":[177],"Differential":[178],"analysis":[180,382],"performed":[182],"LIMMA,":[184],"followed":[185,236],"multiple":[187],"test":[188],"correction":[189],"the":[191,389,436,466,478,520,546],"BH":[192],"method.":[193],"Enrichment":[194],"functionally-related":[196],"evaluated":[199,441],"GSEA.":[201],"For":[202],"combination":[203,226,245,443,554],"studies,":[204],"germinal":[206],"center":[207],"(GCB)":[209],"2":[211],"activated":[212],"(ABC)":[214],"DLBCL":[215],"exposed":[217],"increasing":[219,228],"doses":[220,229],"alone":[223],"targeted":[231,487],"agents":[232,488],"72":[234],"hours,":[235],"MTT":[238],"assay.":[239],"Synergy":[240,249,447],"Chou-Talalay":[244],"index":[246],"(CI)":[247],"R":[250],"package.":[251],"Results":[252],"Transcripts":[253],"associated":[254,286,306,412,431],"resistance":[256],"significantly":[260],"enriched":[261,291],"involved":[264,301,363],"cycle":[267],"regulation,":[268],"DNA":[269],"repair,":[270],"structure,":[272],"early":[273],"development,":[275],"E2F/E2F2":[276],"target":[277,296],"genes,":[278,280,294,297],"IL6-dependent":[279],"mRNA":[282],"processing.":[283],"Conversely,":[284],"transcripts":[285,338],"sensitivity":[289,309,524],"hypoxia-regulated":[293],"interferon":[295],"STAT3":[298],"targets,":[299],"glucose":[303,527],"metabolism.":[304],"Genes":[305],"included":[310],"LDHA,":[311],"PGK1":[312],"(glucose":[313],"metabolism)":[314],"VEGFA":[316],"(hypoxia),":[317],"while":[318],"BCL2L1/BCLXL,":[319],"BIRC5/survivin":[320],"(anti-apoptosis),":[321],"ERCC1":[322],"(DNA":[323],"repair),":[324],"TAF1A":[325],"BRD7":[327],"(transcription":[328],"regulation)":[329],"correlated":[331],"reduced":[333],"sensitivity.":[334],"GEP":[335],"identified":[336,388,541],"50":[337],"differentially":[339],"expressed,":[340],"including":[341],"IL6,":[342],"HCK,":[343],"SGK1,":[344],"MARCH1":[345],"TRAFD1,":[347],"between":[348,373,522],"undergoing":[350,536],"apoptosis":[353],"after":[354,469],"exposure.":[356],"GSEA":[357],"significant":[359],"enrichment":[360],"IL-10":[365],"signaling":[366],"pathway.":[367],"While":[368],"association":[372,521],"OTX015<500nM":[376],"presence":[378,394],"translocated":[380],"MYC,":[381],"genetic":[384,542],"features":[387],"ABC":[390],"phenotype":[391],"(P=.008)":[392],"concomitant":[396],"somatic":[397],"mutations":[398,428],"MYD88":[400,422],"CD79B":[402],"CARD11":[404],"wild":[407],"type":[408],"TP53":[409],"(P=.027)":[410],"apoptosis.":[414,537],"Based":[415],"on":[416,571,582],"these":[417],"observations":[418],"since":[420],"mutated":[421],"interacts":[423],"BTK":[425,437],"MYD88/CD79B":[427],"been":[430],"clinical":[433],"responses":[434],"inhibitor":[438,503],"ibrutinib,":[439],"we":[440],"this":[445,481],"compound.":[446],"observed":[449],"particular":[451],"ABC-DLBCL":[453],"a":[455,506,511],"median":[456,512],"CI":[457,513],".04":[459],"(range":[460],".02-.1).":[461],"demonstrated":[463],"down-regulation":[464],"MYD88/JAK/STAT":[467],"pathway":[468,482],"treatment,":[471],"additional":[475],"GEP,":[476],"highlighted":[477],"importance":[479],"activity.":[485],"Other":[486],"(everolimus,":[489],"lenalidomide,":[490],"rituximab,":[491],"decitabine,":[492],"vorinostat)":[493],"appeared":[494],"synergize":[496],"(Fig":[499],"1).":[500],"mTOR":[502],"everolimus":[504],"presented":[505],"very":[507],"strong":[508],"synergism":[509],".11":[515],"(.1-.2),":[516],"accordance":[518],"high":[526,530],"metabolism":[528],"levels":[531],"SGK1":[533],"Conclusions":[538],"Our":[539],"mechanisms":[543],"schemes,":[555],"such":[556],"OTX015/everolimus,":[558],"be":[560],"further":[561],"investigated.":[562],"Disclosures:":[563],"Stathis:":[564],"Oncoethix:":[565],"NCT01713582":[566],"PI":[567],"Other.":[568],"Herait:Oncoethix:":[569],"Membership":[570,581],"an":[572,583],"entity\u2019s":[573,584],"Board":[574,585],"Directors":[576,587],"advisory":[578,589],"committees.":[579,590],"Noel:Oncoethix:":[580],"Inghirami:Oncoethix:":[591],"Research":[592,595],"Funding.":[593,596],"Bertoni:Oncoethix:":[594]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
