{"id":"https://openalex.org/W1425795808","doi":null,"title":"HGS-TR2J, an agonistic, TRAIL receptor 2 monoclonal antibody, actively and rapidly stimulates the TRAIL receptor pathway that leads to significant inhibition of tumor growth in human tumor cell lines in vitro and in vivo","display_name":"HGS-TR2J, an agonistic, TRAIL receptor 2 monoclonal antibody, actively and rapidly stimulates the TRAIL receptor pathway that leads to significant inhibition of tumor growth in human tumor cell lines in vitro and in vivo","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W1425795808","mag":"1425795808"},"language":"en","primary_location":{"id":"mag:1425795808","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/65/9_Supplement/1038.2","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002703541","display_name":"Robin C. Humphreys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Humphreys","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056160650","display_name":"Lindsey Shepard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey Shepard","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015170880","display_name":"Carol Poortman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Poortman","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112272373","display_name":"Kathy McCormick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K McCormick","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039294550","display_name":"Clint Lincoln","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clint Lincoln","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000950853","display_name":"Wendy Halpern","orcid":"https://orcid.org/0000-0002-5060-6874","observed_orcids":["https://orcid.org/0000-0002-5060-6874"]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Halpern","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":"https://orcid.org/0000-0002-5060-6874","affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023294934","display_name":"Paul A. Moore","orcid":"https://orcid.org/0000-0001-6057-7539","observed_orcids":["https://orcid.org/0000-0001-6057-7539"]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Moore","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":"https://orcid.org/0000-0001-6057-7539","affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015750123","display_name":"Jim Fikes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jim Fikes","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109073765","display_name":"Vivian R. Albert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108865366","display_name":"Human Genome Sciences (United States)","ror":"https://ror.org/05k1yyh03","country_code":"US","type":"company","lineage":["https://openalex.org/I108865366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivian R. Albert","raw_affiliation_strings":["Human Genome Sciences (Rockville, MD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genome Sciences (Rockville, MD)","institution_ids":["https://openalex.org/I108865366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I108865366"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.06437366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"65","issue":null,"first_page":"1038","last_page":"1038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trail-receptor-2","display_name":"TRAIL receptor 2","score":0.9340000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6980000138282776},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5899999737739563},{"id":"https://openalex.org/keywords/synergistic-cytotoxicity","display_name":"synergistic cytotoxicity","score":0.828000009059906},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5816479921340942},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5451428890228271},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5390128493309021},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5093001127243042},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4922553598880768},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4752364158630371},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.446583092212677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43738365173339844},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35206884145736694},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2998943328857422},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2855048179626465},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07545140385627747},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1425795808","doi":null,"is_oa":false,"landing_page_url":"http://cancerres.aacrjournals.org/content/65/9_Supplement/1038.2","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2024370221","https://openalex.org/W1974144614","https://openalex.org/W1979746577","https://openalex.org/W2008465548","https://openalex.org/W169929169","https://openalex.org/W4248792710","https://openalex.org/W2080613199","https://openalex.org/W2086207288","https://openalex.org/W2283718522","https://openalex.org/W1470130797"],"abstract_inverted_index":{"4388":[0],"Tumor":[2,152,236],"necrosis":[3],"factor":[4],"related":[5],"apoptosis-inducing":[6],"ligand":[7,58],"(TRAIL)":[8],"death":[9,63],"receptors":[10],"are":[11],"abundantly":[12],"expressed":[13,180],"on":[14,182,221],"the":[15,38,57,117,124,130,183,208,243,255,281,287,371,381,389],"cell":[16,33,78,142,153,174,184,193,204,222,343,374],"surface":[17,185,375],"of":[18,21,26,51,69,119,137,211,246,250,257,263,283,294,299,340,357,383,391],"a":[19,70,99,218,277,349,386],"majority":[20],"human":[22,140,202,341,392],"tumor":[23,141,173,178,203,251,264,272,288,342],"cells.":[24],"Activation":[25],"this":[27,120,365],"pathway":[28,42,301,359],"rapidly":[29,230],"leads":[30],"to":[31,60,122,165,189,195,307,364],"programmed":[32,77],"death.":[34,79],"These":[35,378],"characteristics":[36],"make":[37],"TRAIL":[39],"receptor":[40,64,376],"(TRAIL-R)":[41],"an":[43,290,297,338,355],"attractive":[44],"target":[45],"for":[46,96,157,373,388],"cancer":[47,100],"therapeutic":[48,101,387],"agents.":[49,151,213],"Binding":[50],"agonist":[52],"monoclonal":[53,85],"antibodies":[54],"(mAbs)":[55],"or":[56,145],"TRAIL,":[59],"either":[61],"functional":[62],"(TRAIL-R1,":[65],"TRAIL-R2)":[66],"induces":[67,348],"activation":[68],"protease-mediated":[71],"signaling":[72,126],"cascade":[73,127],"that":[74],"culminates":[75],"in":[76,107,131,134,139,146,170,197,265,271,280,286,292,310,313,331,337,352],"A":[80],"fully":[81],"human,":[82],"agonist,":[83],"TRAIL-R2":[84,125,181,311],"antibody":[86],"(mAb),":[87],"HGS-TR2J":[88,138,166,196,206,324,384],"(also":[89],"known":[90],"as":[91,98,315,385],"KMTR-2),":[92],"is":[93,105],"being":[94],"developed":[95],"use":[97],"agent.":[102],"This":[103,345],"mAb":[104,121,368],"currently":[106],"Phase":[108],"I":[109],"clinical":[110],"safety":[111],"trials.":[112],"Here":[113],"we":[114],"have":[115],"evaluated":[116,156],"ability":[118],"activate":[123],"and":[128,133,163,167,186,226,259,289,330,361],"assessed":[129],"vitro":[132],"vivo":[135],"efficacy":[136],"lines":[143,154,175],"alone":[144,329],"combination":[147,332],"with":[148,234,276,333],"various":[149,334],"chemotherapeutic":[150,168,212,335],"were":[155],"TRAIL-R":[158,300,358,366],"expression":[159,312],"by":[160,317],"flow":[161],"cytometry":[162],"sensitivity":[164,191],"agents":[169],"vitro.":[171,198],"Human":[172],"from":[176],"different":[177,201],"types":[179],"displayed":[187],"moderate":[188],"significant":[190,326],"(50-90%":[192],"death)":[194],"In":[199,303,319],"several":[200,266],"lines,":[205],"enhanced":[207],"cytotoxic":[209],"activity":[210,347,360],"Importantly,":[214],"some":[215],"combinations":[216],"elicited":[217],"synergistic":[219],"effect":[220],"viability.":[223],"Pre-established":[224],"NSCLC":[225],"colon":[227],"adenocarcinoma":[228],"xenografts":[229,314],"regressed":[231],"after":[232,242],"treatment":[233,258,390],"HGS-TR2J.":[235,247],"volume":[237,273],"was":[238,274],"significantly":[239],"reduced":[240],"(90-75%)":[241],"first":[244],"dose":[245],"The":[248,268],"inhibition":[249],"growth":[252],"persisted":[253],"throughout":[254],"duration":[256],"generated":[260],"complete":[261],"elimination":[262],"animals.":[267],"rapid":[269],"decrease":[270],"associated":[275],"concomitant":[278,350],"increase":[279,291,351],"number":[282],"apoptotic":[284],"cells":[285],"levels":[293],"active":[295,353],"caspases,":[296,354],"indicator":[298,356],"activity.":[302],"addition,":[304],"there":[305],"appeared":[306],"be":[308],"fluctuations":[309],"determined":[316],"immunohistochemistry.":[318],"summary,":[320],"these":[321],"data":[322],"reveal":[323],"has":[325],"anti-tumor":[327,346],"activity,":[328],"agents,":[336],"array":[339],"lines.":[344],"apoptosis.":[362],"Sensitivity":[363],"specific":[367],"extends":[369],"beyond":[370],"requirement":[372],"expression.":[377],"studies":[379],"illuminate":[380],"potential":[382],"cancer.":[393]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
