{"id":"https://openalex.org/W142554672","doi":null,"title":"The significance of tumor contamination in the bone marrow from high-risk primary breast cancer patients treated with high-dose chemotherapy and hematopoietic support.","display_name":"The significance of tumor contamination in the bone marrow from high-risk primary breast cancer patients treated with high-dose chemotherapy and hematopoietic support.","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W142554672","mag":"142554672","pmid":"https://pubmed.ncbi.nlm.nih.gov/9267669"},"language":"en","primary_location":{"id":"pmid:9267669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9267669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014505996","display_name":"James J. Vredenburgh","orcid":"https://orcid.org/0000-0002-2935-6057","observed_orcids":["https://orcid.org/0000-0002-2935-6057"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J J Vredenburgh","raw_affiliation_strings":["Duke University Bone Marrow Transplant Program, Duke University Medical Center, Durham, North Carolina 27710, USA. vrede001@mc.duke.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Bone Marrow Transplant Program, Duke University Medical Center, Durham, North Carolina 27710, USA. vrede001@mc.duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061136699","display_name":"O. SILVA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111691313","display_name":"Gloria Broadwater","orcid":"https://orcid.org/0000-0002-9845-7564","observed_orcids":["https://orcid.org/0000-0002-9845-7564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Broadwater","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045600839","display_name":"David C. Berry","orcid":"https://orcid.org/0000-0003-3070-0182","observed_orcids":["https://orcid.org/0000-0003-3070-0182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Berry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070855401","display_name":"K DeSombre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K DeSombre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011457263","display_name":"Christy Tyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Tyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109576984","display_name":"William P. Petros","orcid":"https://orcid.org/0000-0003-2706-5931","observed_orcids":["https://orcid.org/0000-0003-2706-5931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W P Petros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113525750","display_name":"W. P. Peters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W P Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067595997","display_name":"Robert C. Bast","orcid":"https://orcid.org/0000-0003-4621-8462","observed_orcids":["https://orcid.org/0000-0003-4621-8462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R C Bast","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5477,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.90505779,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"2","first_page":"91","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.46630001068115234,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.46630001068115234,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.39309999346733093,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-cell-contamination","display_name":"tumor cell contamination","score":0.8299999833106995},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.9160000085830688},{"id":"https://openalex.org/keywords/peripheral-blood-progenitor-cells","display_name":"peripheral blood progenitor cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/high-risk-breast-cancer","display_name":"high-risk breast cancer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/axillary-lymph-node-metastasis","display_name":"axillary lymph node metastasis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.824999988079071},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.824999988079071},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/carmustine","display_name":"BCNU","score":0.984000027179718},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8209999799728394},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/breast-cancer-recurrence","display_name":"breast cancer recurrence","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8880534172058105},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.776023805141449},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5936194062232971},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5244274735450745},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5095670223236084},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5057718753814697},{"id":"https://openalex.org/C2780147359","wikidata":"https://www.wikidata.org/wiki/Q415869","display_name":"Carmustine","level":4,"score":0.48533836007118225},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4592873752117157},{"id":"https://openalex.org/C2777649267","wikidata":"https://www.wikidata.org/wiki/Q340695","display_name":"Axillary lymph nodes","level":4,"score":0.43453699350357056},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4283791184425354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4186205565929413},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3856484889984131},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33595460653305054},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2804579734802246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.060477614402770996},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9267669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9267669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation","raw_type":"Clinical Trial"},{"id":"mag:142554672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9267669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6708791839","display_name":"Novel Approaches to Stem Cell Transplantation","funder_award_id":"P01CA047741","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2323031981","https://openalex.org/W2089447909","https://openalex.org/W1964709983","https://openalex.org/W2342082762","https://openalex.org/W2409588873","https://openalex.org/W1694811452","https://openalex.org/W2413041591","https://openalex.org/W2061051572","https://openalex.org/W2272428616","https://openalex.org/W2318364599"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,11,70,86,113,122,129,137,146,160,162,168,179,184,188,195,198,220,224,259,283,287,290,294],"incidence":[3],"and":[4,35,42,76,106,155,171,187,204,213,231,251,266,280],"significance":[5,288],"of":[6,10,19,72,85,100,112,121,128,136,145,164,183,190,194,197,200,206,219,282,289,293],"tumor":[7,118,133,165,180,201,261,284,291],"cell":[8,57,119,134,143,181,217],"contamination":[9,120,135,144,182,218,292],"bone":[12,73,123,147,185,221,295],"marrow":[13,74,148,186,222],"or":[14,30],"peripheral":[15,77,138],"blood":[16,78,139],"progenitor":[17,79,140],"cells":[18,80,166,202,262],"patients":[20,88,116,131,235],"who":[21,36,89,236],"had":[22,117,132],"high":[23,38,247],"risk":[24],"primary":[25],"breast":[26],"cancer":[27,103],"involving":[28],"10":[29],"more":[31],"axillary":[32],"lymph":[33,208],"nodes":[34,209],"received":[37,91],"dose":[39,51,241,248],"cyclophosphamide,":[40],"cisplatin,":[41],"carmustine":[43],"with":[44,151,228,239,246,276],"hematopoietic":[45,56,252],"support":[46],"as":[47],"consolidation":[48,245],"following":[49],"standard":[50,240],"adjuvant":[52],"chemotherapy.":[53],"The":[54,94,192],"autologous":[55],"products":[58],"were":[59,67,81,237],"evaluated":[60,82],"in":[61,264],"85":[62],"eligible":[63],"patients.":[64],"Eighty-three":[65],"samples":[66],"available":[68],"from":[69,83,223],"time":[71],"harvest,":[75],"57":[84,130],"65":[87],"additionally":[90],"these":[92],"products.":[93],"screening":[95],"technique":[96],"utilized":[97],"a":[98,271],"panel":[99],"four":[101],"anti-breast":[102],"monoclonal":[104],"antibodies":[105],"an":[107],"immunohistochemical":[108],"technique.":[109],"Thirty":[110],"(36%)":[111],"83":[114],"evaluable":[115],"marrow.":[124,296],"Only":[125],"2":[126],"(4%)":[127],"cells.":[141],"Tumor":[142,216],"was":[149,175],"associated":[150,227],"shorter":[152,169,229],"disease-free":[153,170,212,230],"survival":[154,233],"overall":[156,172,214,232],"survival.":[157,173,215],"In":[158],"addition,":[159],"higher":[161],"number":[163,199,205],"identified,":[167],"There":[174],"no":[176],"relationship":[177],"between":[178],"site":[189],"relapse.":[191],"combination":[193],"log":[196],"+1":[203],"positive":[207],"predicted":[210],"both":[211],"harvest":[225],"is":[226,255],"for":[234],"treated":[238],"chemotherapy":[242],"followed":[243],"by":[244],"alkylating":[249],"agents":[250],"support.":[253],"It":[254],"unclear":[256],"what":[257],"role":[258],"contaminating":[260],"have":[263],"relapse,":[265],"they":[267],"may":[268,285],"just":[269],"be":[270],"high-risk":[272],"marker.":[273],"A":[274],"comparison":[275],"other":[277],"prognostic":[278],"factors":[279],"characteristics":[281],"determine":[286]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}