{"id":"https://openalex.org/W14254282","doi":null,"title":"Evidence based evaluation of immuno-coagulatory interventions in critical care.","display_name":"Evidence based evaluation of immuno-coagulatory interventions in critical care.","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W14254282","mag":"14254282","pmid":"https://pubmed.ncbi.nlm.nih.gov/21893014"},"language":"en","primary_location":{"id":"pmid:21893014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21893014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical bulletin","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040905987","display_name":"Arash Afshari","orcid":"https://orcid.org/0000-0001-5117-9715","observed_orcids":["https://orcid.org/0000-0001-5117-9715"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Arash Afshari","raw_affiliation_strings":["Department of Anaesthesiology, Juliane Marie Center, Rigshospitalet, University of Copenhagen, Blegdamsvej, Denmark. arriba.a@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Juliane Marie Center, Rigshospitalet, University of Copenhagen, Blegdamsvej, Denmark. arriba.a@gmail.com","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040905987"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"],"apc_list":null,"apc_paid":null,"fwci":1.3502,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.81291695,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"58","issue":"9","first_page":"B4316","last_page":"B4316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.10859999805688858,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.05339999869465828,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/critical-care","display_name":"intensive care","score":0.6669999957084656},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.9779999852180481},{"id":"https://openalex.org/keywords/inhaled-nitric-oxide","display_name":"inhaled nitric oxide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/thromboelastography","display_name":"thromboelastography","score":0.9750000238418579},{"id":"https://openalex.org/keywords/thromboelastometry","display_name":"thromboelastometry","score":0.9810000061988831},{"id":"https://openalex.org/keywords/massive-transfusion","display_name":"massive transfusion","score":0.9570000171661377},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9259999990463257},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9950000047683716},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.6729999780654907},{"id":"https://openalex.org/keywords/trial-sequential-analysis","display_name":"trial sequential analysis","score":0.47099998593330383},{"id":"https://openalex.org/keywords/risk-of-bias","display_name":"risk of bias","score":0.7689999938011169},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9375379085540771},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.7444045543670654},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.633014440536499},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.6112045049667358},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5808912515640259},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.5694535374641418},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5206836462020874},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.45046183466911316},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.4446676969528198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17782005667686462},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.08853298425674438},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000990","descriptor_name":"Antithrombin III","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001778","descriptor_name":"Blood Coagulation Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001778","descriptor_name":"Blood Coagulation Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006487","descriptor_name":"Hemostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21893014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21893014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical bulletin","raw_type":"Journal Article"},{"id":"mag:14254282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21893014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":180,"referenced_works":["https://openalex.org/W11598776","https://openalex.org/W12312492","https://openalex.org/W72549793","https://openalex.org/W133465157","https://openalex.org/W150606601","https://openalex.org/W1247968195","https://openalex.org/W1501809547","https://openalex.org/W1525161423","https://openalex.org/W1555619669","https://openalex.org/W1600041372","https://openalex.org/W1774591799","https://openalex.org/W1783656977","https://openalex.org/W1837652839","https://openalex.org/W1965897301","https://openalex.org/W1966232918","https://openalex.org/W1968095515","https://openalex.org/W1968236889","https://openalex.org/W1968494740","https://openalex.org/W1971252299","https://openalex.org/W1971537896","https://openalex.org/W1972266294","https://openalex.org/W1974404062","https://openalex.org/W1976357112","https://openalex.org/W1978779220","https://openalex.org/W1978981469","https://openalex.org/W1980717583","https://openalex.org/W1982130175","https://openalex.org/W1984378104","https://openalex.org/W1984737917","https://openalex.org/W1986215651","https://openalex.org/W1986624981","https://openalex.org/W1988178206","https://openalex.org/W1989539384","https://openalex.org/W1990760584","https://openalex.org/W1993397663","https://openalex.org/W1996470340","https://openalex.org/W1996580954","https://openalex.org/W1998397225","https://openalex.org/W1999218614","https://openalex.org/W2005167346","https://openalex.org/W2005211946","https://openalex.org/W2005888993","https://openalex.org/W2007320066","https://openalex.org/W2009341450","https://openalex.org/W2009732524","https://openalex.org/W2010581868","https://openalex.org/W2010896933","https://openalex.org/W2011932878","https://openalex.org/W2020513354","https://openalex.org/W2021000405","https://openalex.org/W2023249623","https://openalex.org/W2023482608","https://openalex.org/W2023598977","https://openalex.org/W2023749154","https://openalex.org/W2025073184","https://openalex.org/W2025563165","https://openalex.org/W2025651303","https://openalex.org/W2025893393","https://openalex.org/W2029278285","https://openalex.org/W2029491963","https://openalex.org/W2030560722","https://openalex.org/W2030824516","https://openalex.org/W2031326228","https://openalex.org/W2032541700","https://openalex.org/W2033289105","https://openalex.org/W2033890227","https://openalex.org/W2036260951","https://openalex.org/W2036733648","https://openalex.org/W2036891958","https://openalex.org/W2038075430","https://openalex.org/W2038886783","https://openalex.org/W2043699711","https://openalex.org/W2043759984","https://openalex.org/W2044796027","https://openalex.org/W2046391772","https://openalex.org/W2046991786","https://openalex.org/W2047562441","https://openalex.org/W2048635427","https://openalex.org/W2048687135","https://openalex.org/W2049282549","https://openalex.org/W2051556928","https://openalex.org/W2054938569","https://openalex.org/W2056439589","https://openalex.org/W2057727552","https://openalex.org/W2058137293","https://openalex.org/W2058406121","https://openalex.org/W2058563954","https://openalex.org/W2059130611","https://openalex.org/W2060208199","https://openalex.org/W2063908549","https://openalex.org/W2066896354","https://openalex.org/W2067430442","https://openalex.org/W2067963759","https://openalex.org/W2071415780","https://openalex.org/W2072165789","https://openalex.org/W2072492033","https://openalex.org/W2074432289","https://openalex.org/W2076682535","https://openalex.org/W2077901096","https://openalex.org/W2080712219","https://openalex.org/W2081814119","https://openalex.org/W2082479261","https://openalex.org/W2082942950","https://openalex.org/W2083931054","https://openalex.org/W2086148792","https://openalex.org/W2088438184","https://openalex.org/W2089296529","https://openalex.org/W2090061778","https://openalex.org/W2091685079","https://openalex.org/W2092102192","https://openalex.org/W2093216413","https://openalex.org/W2093852073","https://openalex.org/W2096792421","https://openalex.org/W2102696978","https://openalex.org/W2103935614","https://openalex.org/W2105924050","https://openalex.org/W2106647227","https://openalex.org/W2107328434","https://openalex.org/W2110970000","https://openalex.org/W2111127564","https://openalex.org/W2111176155","https://openalex.org/W2112339576","https://openalex.org/W2113426096","https://openalex.org/W2113535256","https://openalex.org/W2115176304","https://openalex.org/W2115301416","https://openalex.org/W2117294447","https://openalex.org/W2118266607","https://openalex.org/W2121473161","https://openalex.org/W2122044177","https://openalex.org/W2122513836","https://openalex.org/W2122587183","https://openalex.org/W2124741410","https://openalex.org/W2126112458","https://openalex.org/W2127765911","https://openalex.org/W2129921286","https://openalex.org/W2132206417","https://openalex.org/W2132266880","https://openalex.org/W2132345790","https://openalex.org/W2134833483","https://openalex.org/W2135177111","https://openalex.org/W2138188443","https://openalex.org/W2139294235","https://openalex.org/W2139706988","https://openalex.org/W2141281326","https://openalex.org/W2144504916","https://openalex.org/W2145053281","https://openalex.org/W2145577370","https://openalex.org/W2147866356","https://openalex.org/W2148321601","https://openalex.org/W2148706741","https://openalex.org/W2151320901","https://openalex.org/W2153316233","https://openalex.org/W2154611259","https://openalex.org/W2154762721","https://openalex.org/W2154925467","https://openalex.org/W2155668811","https://openalex.org/W2156003673","https://openalex.org/W2156098321","https://openalex.org/W2157059584","https://openalex.org/W2157508850","https://openalex.org/W2157775267","https://openalex.org/W2157823046","https://openalex.org/W2160691650","https://openalex.org/W2160795579","https://openalex.org/W2161328469","https://openalex.org/W2162249417","https://openalex.org/W2163053457","https://openalex.org/W2163223903","https://openalex.org/W2163225148","https://openalex.org/W2163798517","https://openalex.org/W2163814324","https://openalex.org/W2166708826","https://openalex.org/W2167232134","https://openalex.org/W2171993752","https://openalex.org/W2209831038","https://openalex.org/W2289407580","https://openalex.org/W2331384579","https://openalex.org/W2331697328","https://openalex.org/W2499572790"],"related_works":["https://openalex.org/W7096688668","https://openalex.org/W1988178206","https://openalex.org/W208593668","https://openalex.org/W2725151597","https://openalex.org/W2554135691","https://openalex.org/W2272987617","https://openalex.org/W2030780661","https://openalex.org/W2897787692","https://openalex.org/W4388930191","https://openalex.org/W2778912293"],"abstract_inverted_index":{"UNLABELLED:":[0],"Cochrane":[1,154,184,211],"systematic":[2,29,128,169,187,288],"reviews":[3,30,129,172,188,289],"with":[4,63,121,198,296,308,333,368,561,737],"meta-analyses":[5],"of":[6,19,36,47,74,130,140,182,189,214,268,293,301,311,318,329,362,365,382,424,428,434,462,466,486,505,521,528,540,552,597,604,652,671,680,706,708,716,740,745,752],"randomised":[7,132,734],"trials":[8,295,303,307,585,673,693,736],"provide":[9],"guidance":[10],"for":[11,80,89,103,186,245,259,632,657,732],"clinical":[12,25,40,59,133,205,233,635,650,735],"practice":[13],"and":[14,24,57,95,105,163,195,203,227,240,243,257,271,274,278,326,369,409,413,432,441,682,742],"health-care":[15],"decision-making.":[16],"In":[17],"case":[18],"disagreements":[20],"between":[21],"research":[22],"evidence":[23,646,705],"practice,":[26],"high":[27,64],"quality":[28,202],"can":[31],"facilitate":[32],"implementation":[33],"or":[34,72,110,262,335,367,507,509,533,547,557,565,599,696,711],"deimplementation":[35],"medical":[37],"interventions":[38,52,656],"into":[39],"practice.":[41],"This":[42],"applies":[43],"especially":[44],"to":[45,113,148,176,200,276,355,390,407,464,476,481,496,545,580,612,616,647,748],"treatment":[46],"critically":[48,81],"ill":[49,82],"patients":[50,120],"where":[51,146],"are":[53,61],"most":[54],"often":[55],"costly":[56],"the":[58,69,137,153,161,164,180,183,282,302,319,380,437,454,460,484,503,526,549,602,633,649,653,665,672,691,717,750,753],"conditions":[60],"associated":[62],"mortality.":[65,589],"OBJECTIVES:":[66],"To":[67,135],"assess":[68],"potential":[70],"benefits":[71],"harms":[73],"1)":[75,331],"antithrombin":[76],"III":[77,339,377],"(AT":[78],"III)":[79],"patients;":[83],"2)":[84,392],"inhaled":[85],"nitric":[86],"oxide":[87],"(INO)":[88],"acute":[90,96],"respiratory":[91],"distress":[92],"syndrome":[93],"(ARDS)":[94],"lung":[97],"injury":[98],"(ALI);":[99],"3)":[100,513],"aerosolized":[101,529],"prostacyclin":[102,530],"ARDS":[104],"ALI;":[106],"4)":[107,559],"thrombelastography":[108],"(TEG)":[109],"thromboelastometry":[111],"(ROTEM)":[112],"monitor":[114],"haemotherapy":[115],"versus":[116],"usual":[117],"care":[118,439,662],"in":[119,284,410,436,451,453,531,555,660,690],"massive":[122],"transfusion.":[123],"METHODS:":[124],"We":[125,191,229,235,248,265,443,514,641],"performed":[126,174,192],"four":[127],"relevant":[131,269],"trials.":[134,234,247,264],"quantify":[136],"estimated":[138],"effect":[139,398,423,571,596,621],"various":[141,204],"interventions,":[142],"we":[143,542],"conducted":[144],"meta-analyses,":[145],"appropriate,":[147],"determine":[149],"intervention":[150,554],"effects":[151],"using":[152],"Collaboration":[155],"methodology,":[156],"trial":[157,524,684],"sequential":[158],"analyses":[159,197,359,591],"(TSA),":[160],"GRADE,":[162],"PRISMA-guidelines":[165],"when":[166],"conducting":[167],"our":[168],"reviews.":[170],"All":[171],"were":[173,208,304,543],"according":[175],"published":[177],"protocols":[178],"following":[179],"recommendations":[181],"Handbook":[185],"interventions.":[190,755],"multiple":[193],"subgroup":[194,358,412],"sensitivity":[196,414],"regard":[199],"methodological":[201,314,676],"outcomes.":[206,625],"Trials":[207,216,254],"identified":[209],"through":[210],"Central":[212],"Register":[213],"Controlled":[215],"(CENTRAL),":[217],"MEDLINE,":[218],"EMBASE":[219],"Science":[220],"Citation":[221],"Index-Expanded,":[222],"The":[223,686],"Chinese":[224],"Biomedical":[225],"Database":[226],"LILACS.":[228],"included":[230,290,692],"all":[231],"randomized":[232],"hand-searched":[236],"reference":[237],"lists,":[238],"reviews,":[239],"contacted":[241],"authors":[242],"experts":[244],"additional":[246],"searched":[249],"ClinicalTrials.gov,":[250],"Centre":[251],"Watch":[252],"Clinical":[253],"Listing":[255],"Service":[256],"ControlledTrials.com":[258],"missed,":[260],"unreported,":[261],"ongoing":[263],"screened":[266],"bibliographies":[267],"articles":[270],"conference":[272],"proceedings":[273],"wrote":[275],"trialists":[277],"pharmaceutical":[279],"companies":[280],"producing":[281],"drugs":[283],"question.":[285],"RESULTS:":[286],"Four":[287],"a":[291,445,593,709],"total":[292],"44":[294],"5,551":[297],"patients.":[298],"Only":[299],"15":[300],"classified":[305],"as":[306,459],"low":[309,519,738,743],"risk":[310,347,361,381,485,504,520,739,744],"bias":[312,522,741],"(high":[313],"quality)":[315],"regarding":[316],"generation":[317],"allocation":[320,322],"sequence,":[321],"concealment,":[323],"blinding,":[324],"follow-up":[325],"other":[327,623],"types":[328],"bias.":[330],"Compared":[332,560],"placebo":[334],"no":[336,395,422,568],"intervention,":[337],"AT":[338,376],"did":[340,499,642],"not":[341,500,643,698,703,721],"significantly":[342,378,482,501],"affect":[343,502],"overall":[344,400,573],"mortality":[345,401,574],"(relative":[346],"(RR)":[348],"0.96,":[349],"95%":[350,387,404,473,493,577,609],"confidence":[351],"interval":[352],"(CI)":[353],"0.89":[354],"1.03).":[356],"No":[357],"on":[360,399,426,536,572,588,601,622,664],"bias,":[363],"populations":[364],"patients,":[366,681],"without":[370],"adjuvant":[371],"heparin":[372],"yielded":[373],"significant":[374,397,570,595,620],"results.":[375,418],"increased":[379],"bleeding":[383,506,605],"events":[384],"(RR":[385,402,491,575],"1.52,":[386],"CI":[388,405,474,494,578,610],"1.30":[389],"1.78).":[391],"INO":[393,425,479],"showed":[394,567],"statistically":[396,446,569,594,619],"1.06,":[403],"0.93":[406],"1.22)":[408],"several":[411,733],"analyses,":[415],"indicating":[416],"robust":[417],"Limited":[419],"data":[420,587,688],"demonstrated":[421,592],"duration":[427],"ventilation,":[429],"ventilator-free":[430],"days,":[431],"length":[433],"stay":[435],"intensive":[438],"unit":[440],"hospital.":[442],"found":[444,515],"significant,":[447],"but":[448,498,582,614,701],"transient":[449],"improvement":[450],"oxygenation":[452],"first":[455],"24":[456],"hours,":[457],"expressed":[458],"ratio":[461],"PO2":[463],"fraction":[465],"inspired":[467],"oxygen":[468],"(mean":[469],"difference":[470],"(MD)":[471],"15.91,":[472],"8.25":[475],"23.56).":[477],"However,":[478,626],"appears":[480],"increase":[483],"renal":[487],"impairment":[488],"among":[489],"adults":[490],"1.59,":[492],"1.17":[495],"2.16)":[497],"methaemoglobin":[508],"nitrogen":[510],"dioxide":[511],"formation.":[512],"only":[516,583],"one":[517],"small":[518,678],"paediatric":[523],"examining":[525],"role":[527],"ALI":[532,556],"ARDS.":[534,558],"Based":[535],"this":[537,553,628],"limited":[538],"amount":[539,603],"data,":[541],"unable":[544],"support":[546,648],"refute":[548],"routine":[550],"use":[551,651,659,751],"standard":[562],"treatment,":[563],"TEG":[564,598],"ROTEM":[566,600],"0.77,":[576],"0.35":[579],"1.72)":[581],"five":[584],"provided":[586,689],"Our":[590],"(MD":[606],"-85.05":[607],"ml,":[608],"-140.68":[611],"-29.42)":[613],"failed":[615],"show":[617],"any":[618],"predefined":[624],"whether":[627],"reduction":[629],"has":[630],"implication":[631],"patient's":[634],"condition":[636],"is":[637,702,728],"still":[638],"uncertain.":[639],"CONCLUSION:":[640],"find":[644],"reliable":[645],"assessed":[654,754],"immuno-coagulatory":[655],"general":[658],"critical":[661],"based":[663],"available":[666],"evidence.":[667],"A":[668],"large":[669],"proportion":[670],"had":[674],"serious":[675],"shortcomings,":[677],"number":[679],"short":[683],"duration.":[685],"sparse":[687],"may":[694,697],"be":[695,699],"promising":[700],"necessarily":[704],"absence":[707],"beneficial":[710],"harmful":[712],"effect,":[713],"because":[714],"many":[715],"outcome":[718],"measures":[719],"have":[720],"been":[722],"adequately":[723],"addressed":[724],"so":[725],"far.":[726],"There":[727],"an":[729],"urgent":[730],"need":[731],"random":[746],"error":[747],"evaluate":[749]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}