{"id":"https://openalex.org/W142474670","doi":null,"title":"Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of retinal light damage.","display_name":"Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of retinal light damage.","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W142474670","mag":"142474670","pmid":"https://pubmed.ncbi.nlm.nih.gov/1428709"},"language":"en","primary_location":{"id":"pmid:1428709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1428709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108373567","display_name":"L M Rapp","orcid":"https://orcid.org/0009-0000-3928-3712","observed_orcids":["https://orcid.org/0009-0000-3928-3712"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L M Rapp","raw_affiliation_strings":["Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":null,"display_name":"S C Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S C Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2598,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.87075837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"33","issue":"12","first_page":"3367","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13869","display_name":"Ocular and Laser Science Research","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13869","display_name":"Ocular and Laser Science Research","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0674000009894371,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-phototoxicity","display_name":"retinal phototoxicity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/rhodopsin","display_name":"rhodopsin","score":0.7770000100135803},{"id":"https://openalex.org/keywords/uva-radiation","display_name":"UVA","score":0.8140000104904175},{"id":"https://openalex.org/keywords/short-wavelength-light","display_name":"short-wavelength light","score":0.6430000066757202},{"id":"https://openalex.org/keywords/photoreceptor-loss","display_name":"photoreceptor loss","score":0.8830000162124634},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9079999923706055},{"id":"https://openalex.org/keywords/photoreceptor-recovery","display_name":"photoreceptor recovery","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.9118922352790833},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.644528865814209},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5837633013725281},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.5445818901062012},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5445166230201721},{"id":"https://openalex.org/C2780916184","wikidata":"https://www.wikidata.org/wiki/Q748049","display_name":"Photoreceptor cell","level":3,"score":0.5256931781768799},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.48826122283935547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45325571298599243},{"id":"https://openalex.org/C60548495","wikidata":"https://www.wikidata.org/wiki/Q7575205","display_name":"Spectral sensitivity","level":3,"score":0.4521496593952179},{"id":"https://openalex.org/C20639190","wikidata":"https://www.wikidata.org/wiki/Q2088972","display_name":"Phototoxicity","level":3,"score":0.447696328163147},{"id":"https://openalex.org/C54497739","wikidata":"https://www.wikidata.org/wiki/Q1474732","display_name":"Photopic vision","level":3,"score":0.44348227977752686},{"id":"https://openalex.org/C98015330","wikidata":"https://www.wikidata.org/wiki/Q907315","display_name":"Absorbance","level":2,"score":0.4433043301105499},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.42779725790023804},{"id":"https://openalex.org/C6260449","wikidata":"https://www.wikidata.org/wiki/Q41364","display_name":"Wavelength","level":2,"score":0.42708659172058105},{"id":"https://openalex.org/C2775987729","wikidata":"https://www.wikidata.org/wiki/Q2336758","display_name":"Green-light","level":3,"score":0.426909476518631},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.38853374123573303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3708729147911072},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.32188183069229126},{"id":"https://openalex.org/C2986477067","wikidata":"https://www.wikidata.org/wiki/Q1210055","display_name":"Red light","level":2,"score":0.12425893545150757},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12280625104904175},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.11709702014923096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09329649806022644},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.07991975545883179},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004056","descriptor_name":"Differential Threshold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D010857","descriptor_name":"Pigment Epithelium of Eye","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1428709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1428709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Comparative Study"},{"id":"mag:142474670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1428709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3901643814","display_name":"LIGHT TOXICITY AND RETINAL DEGENERATION AND AGING","funder_award_id":"R01EY004554","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5581958286","display_name":"P30 - Core Grant for Vision Research","funder_award_id":"P30EY002520","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W195655083","https://openalex.org/W2026715513","https://openalex.org/W2143249129"],"related_works":["https://openalex.org/W124106752","https://openalex.org/W2021103643","https://openalex.org/W1967116285","https://openalex.org/W197021737","https://openalex.org/W2026715513","https://openalex.org/W2026735889","https://openalex.org/W4254359650","https://openalex.org/W2120655195","https://openalex.org/W2071385002","https://openalex.org/W87212611"],"abstract_inverted_index":{"The":[0,123],"histologic":[1,128],"manifestations":[2,129],"of":[3,8,16,26,32,70,88,100,106,115,125,134,148],"rhodopsin-mediated":[4],"versus":[5],"short-wavelength":[6],"classes":[7,99,133],"retinal":[9,81],"phototoxicity":[10],"were":[11,22,102],"compared":[12],"after":[13],"spectral":[14],"exposures":[15],"the":[17,30,40,97,120,131,137],"albino":[18],"rat":[19],"retina.":[20],"Animals":[21],"exposed":[23],"to":[24],"wave-bands":[25],"light":[27,55,63],"centered":[28],"at":[29,64],"peak":[31],"rhodopsin":[33],"absorbance":[34],"(green,":[35],"500":[36],"nm)":[37],"or":[38,146],"in":[39,74,104],"ultraviolet":[41],"A":[42],"(UVA;":[43],"360":[44],"nm).":[45],"Intensity-damage":[46],"curves":[47],"generated":[48],"for":[49,130],"each":[50],"wave-band":[51],"indicated":[52],"that":[53,139],"UVA":[54,91],"was":[56],"50-80":[57],"times":[58],"more":[59],"effective":[60],"than":[61],"green":[62,93],"causing":[65],"photoreceptor":[66,116],"cell":[67,117,149],"losses.":[68],"Examination":[69],"early":[71],"ultrastructural":[72],"changes":[73],"rod":[75],"inner":[76],"segments,":[77,79],"outer":[78],"and":[80,92,112],"pigment":[82],"epithelium":[83],"revealed":[84],"a":[85,142],"remarkable":[86],"degree":[87],"similarity":[89],"between":[90],"light-induced":[94],"damage.":[95],"Furthermore,":[96],"two":[98,132],"damage":[101,111,135],"indistinguishable":[103],"terms":[105],"post-exposure":[107],"recovery":[108],"from":[109],"threshold":[110],"regional":[113],"distribution":[114],"loss":[118],"along":[119],"vertical":[121],"meridian.":[122],"finding":[124],"essentially":[126],"identical":[127],"raises":[136],"possibility":[138],"they":[140],"share":[141],"common":[143],"biochemical":[144],"etiology":[145],"pathway":[147],"destruction.":[150]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}